tumor necrosis factor

詳細情報を見る

同義遺伝子名

TNFSF2, Cachectin, MGC151434, Tumor necrosis factor precursor, Tumor necrosis factor ligand superfamily member 2, tumor necrosis factor, tumor necrosis factor-alpha, DIF, TNF alpha, Tnfsf1a, TNF-alpha, Tnf, Tnfa, TNFalpha, TNF-a, Tnfsf2

発現マップ on BodyParts3D

相対発現量を、人体 3D 画像にマップしたものです。Genechip 組織40分類 の発現パターンを使用しています。

組織40分類別データ

EST nodata
GeneChip 大脳:5.59 小脳:5.60 脳幹:- 脳梁:- 松果体:- 末梢神経:5.35 脊柱:5.72 網膜:6.10 目:6.72 動脈:- 静脈:5.77 リンパ節:6.12 末梢血:- 脾臓:6.40 胸腺:- 骨髄:5.96 脂肪:5.70 骨:6.08 皮膚:5.75
CAGE 大脳:0.10 小脳:- 脳幹:0.31 脳梁:- 松果体:- 末梢神経:- 脊柱:0 網膜:- 目:- 動脈:1.24 静脈:- リンパ節:3.88 末梢血:- 脾臓:2.67 胸腺:2.82 骨髄:- 脂肪:- 骨:2.19 皮膚:1.89
RNA-seq nodata
EST nodata
GeneChip 子宮:5.30 胎盤:5.86 前立腺:5.66 卵巣:5.44 精巣:5.79 心臓:6.15 骨格筋:5.78 食道:- 胃:5.73 腸:5.61 結腸:- 肝臓:5.98 肺:5.37 膀胱:5.57 腎臓:5.76 下垂体:5.65 甲状腺:- 副腎:5.49 膵臓:6.01 乳腺:5.97 唾液腺:5.57
CAGE 子宮:2.51 胎盤:1.65 前立腺:0.84 卵巣:1.35 精巣:0 心臓:- 骨格筋:- 食道:- 胃:1.35 腸:0.42 結腸:1.96     肝臓:0.26    肺:2.03 膀胱:0.33 腎臓:- 下垂体:0.52 甲状腺:- 副腎:1.61 膵臓:2.03 乳腺:1.80 唾液腺:-
RNA-seq nodata

IDs

Refseq ID NM_013693
Gene ID 21926
Unigene ID -
Probe set ID 1419607_at  [Mouse430_2]
Ensembl ID ENSMUSG00000024401

オーソログ対応遺伝子

ヒト[1]  NM_000594
ラット [0]  

染色体

-

遺伝子ファミリー (Interpro ID)

Link to Pubmed  (Pubmed ID)

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遺伝子オントロジー  (GO ID)

Biological Process

GO:0006919  activation of caspase activity
GO:0000187  activation of MAPK activity
GO:0000185  activation of MAPKKK activity
GO:0006915  apoptosis
GO:0019722  calcium-mediated signaling
GO:0001775  cell activation
GO:0008283  cell proliferation
GO:0008652  cellular amino acid biosynthetic process
GO:0045123  cellular extravasation
GO:0071230  cellular response to amino acid stimulus
GO:0071316  cellular response to nicotine
GO:0071407  cellular response to organic cyclic substance
GO:0002439  chronic inflammatory response to antigenic stimulus
GO:0006952  defense response
GO:0042742  defense response to bacterium
GO:0050830  defense response to Gram-positive bacterium
GO:0008630  DNA damage response, signal transduction resulting in induction of apoptosis
GO:0060664  epithelial cell proliferation involved in salivary gland morphogenesis
GO:0030198  extracellular matrix organization
GO:0006006  glucose metabolic process
GO:0006959  humoral immune response
GO:0006955  immune response
GO:0006917  induction of apoptosis
GO:0008625  induction of apoptosis via death domain receptors
GO:0060555  induction of necroptosis by extracellular signals
GO:0006954  inflammatory response
GO:0007254  JNK cascade
GO:0050900  leukocyte migration
GO:0050901  leukocyte tethering or rolling
GO:0031663  lipopolysaccharide-mediated signaling pathway
GO:0000165  MAPKKK cascade
GO:0007275  multicellular organismal development
GO:0070265  necrotic cell death
GO:0010693  negative regulation of alkaline phosphatase activity
GO:0008285  negative regulation of cell proliferation
GO:0002740  negative regulation of cytokine secretion during immune response
GO:0010629  negative regulation of gene expression
GO:0046325  negative regulation of glucose import
GO:0044130  negative regulation of growth of symbiont in host
GO:0032715  negative regulation of interleukin-6 production
GO:0002037  negative regulation of L-glutamate transport
GO:0050995  negative regulation of lipid catabolic process
GO:0045668  negative regulation of osteoblast differentiation
GO:0043242  negative regulation of protein complex disassembly
GO:0000122  negative regulation of transcription from RNA polymerase II promoter
GO:0045892  negative regulation of transcription, DNA-dependent
GO:0045071  negative regulation of viral genome replication
GO:0009887  organ morphogenesis
GO:0030316  osteoclast differentiation
GO:0043065  positive regulation of apoptosis
GO:0060559  positive regulation of calcidiol 1-monooxygenase activity
GO:0043280  positive regulation of caspase activity
GO:0008284  positive regulation of cell proliferation
GO:0045080  positive regulation of chemokine biosynthetic process
GO:0032722  positive regulation of chemokine production
GO:0002876  positive regulation of chronic inflammatory response to antigenic stimulus
GO:0001819  positive regulation of cytokine production
GO:0050715  positive regulation of cytokine secretion
GO:0031622  positive regulation of fever
GO:0051798  positive regulation of hair follicle development
GO:0034116  positive regulation of heterotypic cell-cell adhesion
GO:0002925  positive regulation of humoral immune response mediated by circulating immunoglobulin
GO:0043123  positive regulation of I-kappaB kinase/NF-kappaB cascade
GO:0050729  positive regulation of inflammatory response
GO:0032729  positive regulation of interferon-gamma production
GO:0032741  positive regulation of interleukin-18 production
GO:0032755  positive regulation of interleukin-6 production
GO:0045416  positive regulation of interleukin-8 biosynthetic process
GO:0046330  positive regulation of JNK cascade
GO:0043507  positive regulation of JUN kinase activity
GO:0043406  positive regulation of MAP kinase activity
GO:0051044  positive regulation of membrane protein ectodomain proteolysis
GO:0045840  positive regulation of mitosis
GO:0043525  positive regulation of neuron apoptosis
GO:0042346  positive regulation of NF-kappaB import into nucleus
GO:0051092  positive regulation of NF-kappaB transcription factor activity
GO:0051533  positive regulation of NFAT protein import into nucleus
GO:0045429  positive regulation of nitric oxide biosynthetic process
GO:0045672  positive regulation of osteoclast differentiation
GO:0033138  positive regulation of peptidyl-serine phosphorylation
GO:0043068  positive regulation of programmed cell death
GO:0001934  positive regulation of protein amino acid phosphorylation
GO:0031334  positive regulation of protein complex assembly
GO:0043243  positive regulation of protein complex disassembly
GO:0051897  positive regulation of protein kinase B signaling cascade
GO:0051222  positive regulation of protein transport
GO:0048661  positive regulation of smooth muscle cell proliferation
GO:0050806  positive regulation of synaptic transmission
GO:0051091  positive regulation of transcription factor activity
GO:0045944  positive regulation of transcription from RNA polymerase II promoter
GO:0045893  positive regulation of transcription, DNA-dependent
GO:0045994  positive regulation of translational initiation by iron
GO:0060557  positive regulation of vitamin D biosynthetic process
GO:0000060  protein import into nucleus, translocation
GO:0043491  protein kinase B signaling cascade
GO:0032800  receptor biosynthetic process
GO:0060693  regulation of branching involved in salivary gland morphogenesis
GO:0042127  regulation of cell proliferation
GO:0043122  regulation of I-kappaB kinase/NF-kappaB cascade
GO:0051023  regulation of immunoglobulin secretion
GO:0050796  regulation of insulin secretion
GO:0045670  regulation of osteoclast differentiation
GO:0001932  regulation of protein amino acid phosphorylation
GO:0050708  regulation of protein secretion
GO:0051384  response to glucocorticoid stimulus
GO:0009615  response to virus
GO:0030730  sequestering of triglyceride
GO:0007165  signal transduction
GO:0006927  transformed cell apoptosis
GO:0033209  tumor necrosis factor-mediated signaling pathway

Cellular Component

GO:0009986  cell surface
GO:0009897  external side of plasma membrane
GO:0005576  extracellular region
GO:0005615  extracellular space
GO:0016021  integral to membrane
GO:0005887  integral to plasma membrane
GO:0005622  intracellular
GO:0016020  membrane
GO:0045121  membrane raft
GO:0001891  phagocytic cup
GO:0005886  plasma membrane
GO:0055037  recycling endosome
GO:0030141  secretory granule

Molecular Function

GO:0005125  cytokine activity
GO:0044212  DNA regulatory region binding
GO:0042802  identical protein binding
GO:0002020  protease binding
GO:0005515  protein binding
GO:0005164  tumor necrosis factor receptor binding