neurofibromin 2 (merlin)

 詳細情報を見る

同義遺伝子名

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発現データ

発現マップ on BodyParts3D

相対発現量を、人体 3D 画像にマップしたものです。Genechip 組織40分類 の発現パターンを使用しています。

組織40分類別データ

脳 血 結
EST 大脳:23.90 小脳:- 脳幹:- 脳梁:- 松果体:- 末梢神経:36.90 脊柱:- 網膜:- 目:35.50 動脈:- 静脈:- リンパ節:- 末梢血:- 脾臓:- 胸腺:122.90 骨髄:- 脂肪:147.20 骨:117.10 皮膚:-
GeneChip 大脳:6.60 小脳:6.36 脳幹:6.36 脳梁:- 松果体:- 末梢神経:6.60 脊柱:- 網膜:- 目:6.53 動脈:- 静脈:- リンパ節:- 末梢血:- 脾臓:6.13 胸腺:6.22 骨髄:6.39 脂肪:- 骨:- 皮膚:-
CAGE nodata
RNA-seq nodata
殖 筋 消 肝 肺 腎 泌
EST 子宮:- 胎盤:39.80 前立腺:75.90 卵巣:114.10 精巣:- 心臓:77.60 骨格筋:- 食道:- 胃:- 腸:209.30 結腸:-     肝臓:26.60        肺:50.70    膀胱:- 腎臓:- 下垂体:- 甲状腺:- 副腎:- 膵臓:- 乳腺:- 唾液腺:-
GeneChip 子宮:- 胎盤:- 前立腺:- 卵巣:- 精巣:- 心臓:6.15 骨格筋:6.42 食道:- 胃:- 腸:6 結腸:6.10 肝臓:- 肺:- 膀胱:- 腎臓:6.05 下垂体:6.36 甲状腺:- 副腎:- 膵臓:- 乳腺:- 唾液腺:-
CAGE nodata
RNA-seq nodata

詳細情報

IDs

Refseq ID NM_013193
Gene ID 25744
Unigene ID Rn.46695
Probe set ID rc_AA875629_at  [RG_U34A]
Ensembl ID ENSRNOG00000007948

オーソログ対応遺伝子

ヒト[40]  NM_000268, NM_016418, NM_181825, NM_181828, NM_181829, NM_181830, NM_181831, NM_181832, NM_181833
マウス[4]  NM_010898, NM_016418, NM_181825, NM_181828, NM_181829, NM_181830, NM_181831, NM_181832, NM_181833

染色体

14q21  [85,415,142  -  85,508,807]

遺伝子ファミリー (Interpro ID)

IPR019749  Band 4.1 domain
IPR019750  Band 4.1 subgroup
IPR011174  Ezrin/radixin/moesin
IPR000798  Ezrin/radixin/moesin ERM

Link to Pubmed  (Pubmed ID)

7795605
8889548
9022813
9858254
11316791
12118253
14991710
15598747
15659388
15797715
16398473
16468657
16571745
16885985
17287518
17891137
18199961
19487675
20600642
21182951
22956607

遺伝子オントロジー  (GO ID)

Biological Process

GO:0030036  actin cytoskeleton organization
GO:0045216  cell-cell junction organization
GO:0007398  ectoderm development
GO:0070306  lens fiber cell differentiation
GO:0001707  mesoderm formation
GO:0030308  negative regulation of cell growth
GO:0008285  negative regulation of cell proliferation
GO:0022408  negative regulation of cell-cell adhesion
GO:0008156  negative regulation of DNA replication
GO:0046426  negative regulation of JAK-STAT cascade
GO:0043409  negative regulation of MAPKKK cascade
GO:0006469  negative regulation of protein kinase activity
GO:0042518  negative regulation of tyrosine phosphorylation of Stat3 protein
GO:0042524  negative regulation of tyrosine phosphorylation of Stat5 protein
GO:0042475  odontogenesis of dentine-containing tooth
GO:0051496  positive regulation of stress fiber formation
GO:0042127  regulation of cell proliferation
GO:0014010  Schwann cell proliferation

Cellular Component

GO:0005912  adherens junction
GO:0042995  cell projection
GO:0032154  cleavage furrow
GO:0030864  cortical actin cytoskeleton
GO:0005737  cytoplasm
GO:0005856  cytoskeleton
GO:0005769  early endosome
GO:0019898  extrinsic to membrane
GO:0030175  filopodium
GO:0030027  lamellipodium
GO:0045121  membrane raft
GO:0005730  nucleolus
GO:0005634  nucleus
GO:0048471  perinuclear region of cytoplasm
GO:0005886  plasma membrane
GO:0043234  protein complex
GO:0001726  ruffle
GO:0045202  synapse

Molecular Function

GO:0008013  beta-catenin binding
GO:0008092  cytoskeletal protein binding
GO:0005178  integrin binding
GO:0005515  protein binding
GO:0019904  protein domain specific binding