leukemia inhibitory factor

詳細情報を見る

同義遺伝子名

Lif, Leukemia inhibitory factor precursor, LIF, Differentiation-stimulating factor, leukemia inhibitory factor, D factor

発現マップ on BodyParts3D

相対発現量を、人体 3D 画像にマップしたものです。Genechip 組織40分類 の発現パターンを使用しています。

組織40分類別データ

EST 大脳:- 小脳:- 脳幹:- 脳梁:- 松果体:- 末梢神経:95.50 脊柱:- 網膜:- 目:- 動脈:- 静脈:- リンパ節:172.80 末梢血:14.40 脾臓:237 胸腺:9.90 骨髄:- 脂肪:- 骨:25 皮膚:7.90
GeneChip 大脳:4.20 小脳:4.20 脳幹:- 脳梁:- 松果体:- 末梢神経:4.26 脊柱:4.34 網膜:4.38 目:4.71 動脈:- 静脈:4.22 リンパ節:3.84 末梢血:- 脾臓:4.16 胸腺:- 骨髄:4.32 脂肪:4.12 骨:4.12 皮膚:4.09
CAGE 大脳:0 小脳:- 脳幹:0.07 脳梁:- 松果体:- 末梢神経:- 脊柱:0 網膜:- 目:- 動脈:0.14 静脈:- リンパ節:1.28 末梢血:- 脾臓:0 胸腺:0 骨髄:- 脂肪:- 骨:0 皮膚:0.15
RNA-seq 大脳:0.76 小脳:- 脳幹:- 脳梁:- 松果体:- 末梢神経:- 脊柱:- 網膜:- 目:- 動脈:- 静脈:- リンパ節:- 末梢血:- 脾臓:- 胸腺:- 骨髄:- 脂肪:- 骨:- 皮膚:-
EST 子宮:- 胎盤:- 前立腺:- 卵巣:- 精巣:- 心臓:- 骨格筋:- 食道:- 胃:- 腸:- 結腸:35.20     肝臓:36.20        肺:-    膀胱:- 腎臓:- 下垂体:12.90 甲状腺:- 副腎:- 膵臓:37.50 乳腺:22.90 唾液腺:-
GeneChip 子宮:4.11 胎盤:4.40 前立腺:4.07 卵巣:3.89 精巣:4.50 心臓:4.34 骨格筋:4.04 食道:- 胃:4.23 腸:4.09 結腸:- 肝臓:4.34 肺:4.01 膀胱:4.36 腎臓:4.18 下垂体:4.24 甲状腺:- 副腎:4.05 膵臓:4.58 乳腺:4.35 唾液腺:4.28
CAGE 子宮:2.94 胎盤:0.37 前立腺:0 卵巣:0 精巣:0 心臓:- 骨格筋:- 食道:- 胃:0 腸:0.23 結腸:0.23     肝臓:0    肺:0.17 膀胱:0.18 腎臓:- 下垂体:0 甲状腺:- 副腎:0.14 膵臓:0 乳腺:0.12 唾液腺:-
RNA-seq 子宮:- 胎盤:- 前立腺:- 卵巣:- 精巣:- 心臓:- 骨格筋:- 食道:- 胃:- 腸:- 結腸:-     肝臓:0.60        肺:-    膀胱:- 腎臓:- 下垂体:- 甲状腺:- 副腎:- 膵臓:- 乳腺:- 唾液腺:-

IDs

Refseq ID NM_008501
Gene ID 16878
Unigene ID Mm.4964
Probe set ID 1421206_at  [Mouse430_2]
Ensembl ID ENSMUSG00000034394

オーソログ対応遺伝子

ヒト[1]  NM_002309
ラット [0]  

染色体

-

遺伝子ファミリー (Interpro ID)

Link to Pubmed  (Pubmed ID)

1321343
1457125
1477476
1522892
1561703
1692837
2111155
2119255
2475312
3127201
3128791
3143918
3147726
3186448
7507352
7508917
7520692
7525452
7565937
7586505
7595475
7689430
7698769
7719983
7743917
7826626
7877978
7925026
7957045
8006010
8020098
8050491
8054487
8064301
8138038
8187629
8188294
8207122
8260605
8395365
8401507
8422244
8454050
8497320
8543809
8605875
8607969
8621407
8683100
8755479
8765501
8770940
8787743
8793295
8843390
9073449
9124702
9160706
9175833
9226373
9240457
9254611
9278535
9298977
9435283
9500603
9564824
9593715
9651226
9662407
9740023
9806780
9920829
9924186
9927325
10202003
10205054
10349636
10438970
10455174
10486560
10675625
10704754
10712626
10764413
10803598
10922068
10935540
11042159
11045638
11076861
11089533
11160255
11160399
11203703
11217851
11279117
11435700
11549727
11567054
11683174
11855863
11897091
11934677
11950938
12007288
12050136
12084939
12124777
12392991
12466851
12490192
12591604
12629183
12764151
12782633
12810593
12826573
12860906
14512435
14610273
14657014
14695905
14741342
14970834
14976223
15012602
15117747
15148312
15171696
15178747
15246839
15292206
15358627
15488701
15519241
15576827
15597051
15618884
15634701
15647843
15673569
15702085
15716414
15747579
15785381
15793565
15848385
15985451
16099433
16141072
16141073
16206277
16258063
16291739
16314487
16369772
16407199
16452727
16458863
16467531
16498619
16636663
16648972
16682639
16691571
16781162
16790614
16987252
17021343
17074046
17108182
17150369
17179859
17249568
17313947
17332343
17356004
17360716
17451373
17680539
17935626
18046411
18088375
18239353
18250427
18278460
18287559
18293407
18337516
18385284
18451094
18521186
18546535
18548006
18552402
18829014
18841027
19021297
19091967
19105399
19267953
19342884
19541590
19571885
19598242
19635738
19646521
19693290
19795791
19819227
19906980
19962978
20091786
20124728
20345762
20564184
20598020
20843830
20864644
20962578
20974049
21035850
21094641
21254450
21385842
21402718
21425410
21593477
21613225
21677750
21681859
21731673
21785422
21835648
21930391
21966484
22074622
22100262
22143976
22210859
22285730
22454532
22581855
22682244
22774981
22894638
22905257
22949634
23077604
23258129
23407384
23409146
23628590
23788624
23942233
24008729
24169527

遺伝子オントロジー  (GO ID)

Biological Process

GO:0048708  astrocyte differentiation
GO:0001974  blood vessel remodeling
GO:0046697  decidualization
GO:0007566  embryo implantation
GO:0006955  immune response
GO:0048861  leukemia inhibitory factor signaling pathway
GO:0048286  lung alveolus development
GO:0030324  lung development
GO:0060463  lung lobe morphogenesis
GO:0060426  lung vasculature development
GO:0060135  maternal process involved in female pregnancy
GO:0048644  muscle organ morphogenesis
GO:0016525  negative regulation of angiogenesis
GO:0008285  negative regulation of cell proliferation
GO:0070373  negative regulation of ERK1 and ERK2 cascade
GO:0046888  negative regulation of hormone secretion
GO:0045835  negative regulation of meiosis
GO:0048666  neuron development
GO:0031100  organ regeneration
GO:0051461  positive regulation of adrenocorticotropin secretion
GO:0048711  positive regulation of astrocyte differentiation
GO:0008284  positive regulation of cell proliferation
GO:0045651  positive regulation of macrophage differentiation
GO:0043410  positive regulation of MAPKKK cascade
GO:0010976  positive regulation of neuron projection development
GO:0033138  positive regulation of peptidyl-serine phosphorylation
GO:0033141  positive regulation of peptidyl-serine phosphorylation of STAT protein
GO:0050731  positive regulation of peptidyl-tyrosine phosphorylation
GO:0045944  positive regulation of transcription from RNA polymerase II promoter
GO:0042511  positive regulation of tyrosine phosphorylation of Stat1 protein
GO:0042517  positive regulation of tyrosine phosphorylation of Stat3 protein
GO:0045595  regulation of cell differentiation
GO:0060041  retina development in camera-type eye
GO:0060708  spongiotrophoblast differentiation
GO:0048863  stem cell differentiation
GO:0019827  stem cell maintenance
GO:0060290  transdifferentiation
GO:0060707  trophoblast giant cell differentiation
GO:0042503  tyrosine phosphorylation of Stat3 protein

Cellular Component

GO:0005737  cytoplasm
GO:0005576  extracellular region
GO:0005615  extracellular space

Molecular Function

GO:0005125  cytokine activity
GO:0008083  growth factor activity
GO:0005146  leukemia inhibitory factor receptor binding
GO:0005102  receptor binding