fibroblast growth factor receptor substrate 2

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Synonym

FRS2A, fibroblast growth factor receptor substrate 2, FGFR substrate 2, FRS2, SNT1, SNT-1, FGFR signaling adaptor SNT, SNT, Suc1-associated neurotrophic factor target 1, FRS2alpha, Fibroblast growth factor receptor substrate 2

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:22.50 cerebellum:25.20 brain stem:- corpus callosum/glia:29.20 pineal gland:- peripheral nerve:61.30 spine:- retina:- eye:17.60 artery/aorta:30 vein:- lymphnode:- peripheral blood:18.20 spleen:18.90 thymus:12.90 bone marrow:- adipose:- bone:- skin:-
GeneChip cerebrum:4.62 cerebellum:4.53 brain stem:4.78 corpus callosum/glia:4.46 pineal gland:- peripheral nerve:4.36 spine:4.48 retina:- eye:- artery/aorta:4.53 vein:4.72 lymphnode:4.40 peripheral blood:- spleen:4.33 thymus:4.45 bone marrow:4.60 adipose:4.70 bone:- skin:4.98
CAGE cerebrum:3.70 cerebellum:- brain stem:3.60 corpus callosum/glia:3.82 pineal gland:3.41 peripheral nerve:- spine:3.98 retina:- eye:- artery/aorta:3.31 vein:2.95 lymphnode:2.66 peripheral blood:- spleen:2.65 thymus:2.65 bone marrow:- adipose:3.17 bone:- skin:-
RNA-seq cerebrum:2.95 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:1.11 peripheral blood:- spleen:- thymus:- bone marrow:- adipose:0.21 bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:27.30 placenta:10.90 prostate:33.80 ovary:- testis:4.30 heart:- muscle:20.10 esophagus:- stomach:42.50 intestine:- colon:-     liver/hepato:-        lung:14.70    bladder:- kidney:20.80 pituitary:116 thyroid/parathyroid:- adrenal gland:- pancreas:- breast:55.80 salivary:-
GeneChip uterus:4.45 placenta:4.43 prostate:4.43 ovary:4.57 testis:4.57 heart:4.85 muscle:5.09 esophagus:4.56 stomach:4.64 intestine:4.82 colon:4.58 liver/hepato:4.77 lung:4.47 bladder:- kidney:4.74 pituitary:4.39 thyroid/parathyroid:4.33 adrenal gland:4.49 pancreas:4.82 breast:4.39 salivary:4.61
CAGE uterus:3.26 placenta:3.37 prostate:3.07 ovary:3.27 testis:3.01 heart:3.02 muscle:2.52 esophagus:2.89 stomach:- intestine:2.92 colon:2.88     liver/hepato:2.30    lung:3.06 bladder:3.23 kidney:2.76 pituitary:3.41 thyroid/parathyroid:3.17 adrenal gland:- pancreas:2.54 breast:3.24 salivary:2.69
RNA-seq uterus:- placenta:- prostate:2.09 ovary:1.20 testis:0.90 heart:1.44 muscle:0.64 esophagus:- stomach:- intestine:- colon:1.14     liver/hepato:0.00        lung:0.03    bladder:- kidney:0.79 pituitary:- thyroid/parathyroid:0.45 adrenal gland:0.00 pancreas:- breast:0.56 salivary:-

Gene Information

IDs

Refseq ID NM_006654
Gene ID 10818
Unigene ID Hs.593446
Probe set ID 221308_at  [HG-U133_Plus_2]
Ensembl ID ENSG00000166225
GTEx ID ENSG00000166225

Orthologous Gene

Mouse[1]  NM_177798
Rat[1]  NM_001108097

Chromosomal Region

12q15  [69,864,129  -  69,973,562]

Gene Family (Interpro ID)

-

Link to Pubmed  (Pubmed ID)

7806500
8761293
8780727
9045692
9069267
9182757
9632781
9660748
10092678
10383403
10629055
10650943
10783152
10822386
11090629
11353842
11360177
11390647
11447289
11877385
11997436
12154000
12402043
12419216
12477932
12571252
12660731
12688531
12766061
12974390
15004239
15342556
15488758
15489334
15564375
15738000
16284401
16344560
16893902
17145761
17944804
18189271
18391951
18591461
19103595
19111446
19652666
20881960
21048031
21233699
21596750
21706016
21793095
22151832
22235335
22974441
23393200
23503679
23563607
24706887

Gene Ontology  (GO ID)

Biological Process

GO:0000187  activation of MAPK activity
GO:0000186  activation of MAPKK activity
GO:0008595  determination of anterior/posterior axis, embryo
GO:0007173  epidermal growth factor receptor signaling pathway
GO:0008543  fibroblast growth factor receptor signaling pathway
GO:0030900  forebrain development
GO:0007186  G-protein coupled receptor protein signaling pathway
GO:0001702  gastrulation with mouth forming second
GO:0001759  induction of an organ
GO:0045087  innate immune response
GO:0008286  insulin receptor signaling pathway
GO:0048011  nerve growth factor receptor signaling pathway
GO:0007405  neuroblast proliferation
GO:0046619  optic placode formation involved in camera-type eye
GO:0048015  phosphoinositide-mediated signaling
GO:0060527  prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis
GO:0050678  regulation of epithelial cell proliferation
GO:0007185  transmembrane receptor protein tyrosine phosphatase signaling pathway
GO:0003281  ventricular septum development

Cellular Component

GO:0012505  endomembrane system
GO:0005768  endosome
GO:0005887  integral to plasma membrane
GO:0016020  membrane
GO:0005886  plasma membrane

Molecular Function

GO:0005104  fibroblast growth factor receptor binding
GO:0005158  insulin receptor binding
GO:0005168  neurotrophin TRKA receptor binding
GO:0019211  phosphatase activator activity
GO:0005515  protein binding
GO:0005068  transmembrane receptor protein tyrosine kinase adaptor protein activity