leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 1

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Synonym

LILRB1, CD85j antigen, ILT-2, ILT2, LIR1, MIR-7, MIR7, Immunoglobulin-like transcript 2, Leukocyte immunoglobulin-like receptor 1, Monocyte/macrophage immunoglobulin-like receptor 7, CD85j, LIR-1, CD85, CD85J

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST nodata
GeneChip cerebrum:5.69 cerebellum:5.72 brain stem:5.78 corpus callosum/glia:6 pineal gland:- peripheral nerve:5.43 spine:5.85 retina:- eye:- artery/aorta:5.79 vein:5.85 lymphnode:6.21 peripheral blood:- spleen:6.56 thymus:5.64 bone marrow:6.66 adipose:5.78 bone:- skin:5.93
CAGE cerebrum:1.24 cerebellum:- brain stem:2.03 corpus callosum/glia:2.15 pineal gland:0.82 peripheral nerve:- spine:2.34 retina:- eye:- artery/aorta:1.72 vein:2.25 lymphnode:2.89 peripheral blood:- spleen:4.36 thymus:1.01 bone marrow:- adipose:1.60 bone:- skin:-
RNA-seq cerebrum:0.01 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:2.32 peripheral blood:- spleen:- thymus:- bone marrow:- adipose:0.44 bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST nodata
GeneChip uterus:5.40 placenta:5.58 prostate:5.35 ovary:5.63 testis:5.24 heart:5.79 muscle:5.80 esophagus:5.34 stomach:5.59 intestine:5.89 colon:5.83 liver/hepato:5.88 lung:6.27 bladder:- kidney:5.50 pituitary:5.55 thyroid/parathyroid:5.29 adrenal gland:5.62 pancreas:5.96 breast:5.38 salivary:5.66
CAGE uterus:0.89 placenta:1.90 prostate:1.58 ovary:1.16 testis:0.57 heart:1.17 muscle:0.42 esophagus:1.08 stomach:- intestine:1.24 colon:1.53     liver/hepato:1.81    lung:2.21 bladder:1.15 kidney:1.06 pituitary:0.86 thyroid/parathyroid:0.49 adrenal gland:- pancreas:0.94 breast:1.36 salivary:1.00
RNA-seq uterus:- placenta:- prostate:0.00 ovary:0.18 testis:0.00 heart:0 muscle:0.00 esophagus:- stomach:- intestine:- colon:0.00     liver/hepato:0.24        lung:1.16    bladder:- kidney:0.20 pituitary:- thyroid/parathyroid:0.15 adrenal gland:2.30 pancreas:- breast:0.24 salivary:-

Gene Ontology  (GO ID)

Biological Process

GO:0071222  cellular response to lipopolysaccharide
GO:0051607  defense response to virus
GO:0002774  Fc receptor mediated inhibitory signaling pathway
GO:0002767  immune response-inhibiting cell surface receptor signaling pathway
GO:0032609  interferon-gamma production
GO:0046636  negative regulation of alpha-beta T cell activation
GO:0051926  negative regulation of calcium ion transport
GO:0045786  negative regulation of cell cycle
GO:0002740  negative regulation of cytokine secretion during immune response
GO:0045806  negative regulation of endocytosis
GO:0045077  negative regulation of interferon-gamma biosynthetic process
GO:0032689  negative regulation of interferon-gamma production
GO:0032945  negative regulation of mononuclear cell proliferation
GO:0045953  negative regulation of natural killer cell mediated cytotoxicity
GO:0014063  negative regulation of serotonin secretion
GO:0001915  negative regulation of T cell mediated cytotoxicity
GO:0042130  negative regulation of T cell proliferation
GO:0042536  negative regulation of tumor necrosis factor biosynthetic process
GO:0043065  positive regulation of apoptosis
GO:0045919  positive regulation of cytolysis
GO:0002230  positive regulation of defense response to virus by host
GO:0010628  positive regulation of gene expression
GO:0045944  positive regulation of transcription from RNA polymerase II promoter
GO:0031623  receptor internalization
GO:0050776  regulation of immune response
GO:0009615  response to virus
GO:0007165  signal transduction
GO:0002309  T cell proliferation during immune response

Cellular Component

GO:0005737  cytoplasm
GO:0009897  external side of plasma membrane
GO:0016021  integral to membrane
GO:0005886  plasma membrane

Molecular Function

GO:0030107  HLA-A specific inhibitory MHC class I receptor activity
GO:0030109  HLA-B specific inhibitory MHC class I receptor activity
GO:0042288  MHC class I protein binding
GO:0032393  MHC class I receptor activity
GO:0042803  protein homodimerization activity
GO:0008157  protein phosphatase 1 binding
GO:0042169  SH2 domain binding