lipoic acid synthetase

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Synonym

MGC23245, lipoic acid synthetase, LIAS, LAS, Lip-syn, HUSSY-01, Lipoic acid synthetase, mitochondrial precursor, Lipoate synthase

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:9.50 cerebellum:25.20 brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:30.70 spine:- retina:- eye:17.60 artery/aorta:- vein:- lymphnode:20.20 peripheral blood:- spleen:- thymus:- bone marrow:- adipose:40.30 bone:12.80 skin:28.80
GeneChip cerebrum:5.26 cerebellum:4.86 brain stem:5.61 corpus callosum/glia:5.20 pineal gland:- peripheral nerve:5.51 spine:5.34 retina:- eye:- artery/aorta:4.46 vein:4.63 lymphnode:5.19 peripheral blood:- spleen:5.09 thymus:5.18 bone marrow:4.63 adipose:4.99 bone:- skin:4.75
CAGE cerebrum:2.81 cerebellum:- brain stem:2.95 corpus callosum/glia:2.93 pineal gland:2.66 peripheral nerve:- spine:3.03 retina:- eye:- artery/aorta:2.36 vein:2.63 lymphnode:2.51 peripheral blood:- spleen:2.56 thymus:2.38 bone marrow:- adipose:2.54 bone:- skin:-
RNA-seq cerebrum:2.46 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:2.31 peripheral blood:- spleen:- thymus:- bone marrow:- adipose:1.72 bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:- placenta:18.20 prostate:33.80 ovary:- testis:51.90 heart:38.30 muscle:40.20 esophagus:- stomach:- intestine:32.40 colon:17     liver/hepato:10.60        lung:9.80    bladder:- kidney:62.40 pituitary:- thyroid/parathyroid:- adrenal gland:50.80 pancreas:- breast:- salivary:-
GeneChip uterus:5.14 placenta:4.31 prostate:5.15 ovary:5.75 testis:6.69 heart:5.27 muscle:6.18 esophagus:5.47 stomach:4.86 intestine:5.01 colon:4.64 liver/hepato:5.67 lung:4.33 bladder:- kidney:5.64 pituitary:4.99 thyroid/parathyroid:5.20 adrenal gland:4.98 pancreas:5.24 breast:5.15 salivary:4.87
CAGE uterus:2.50 placenta:2.06 prostate:2.56 ovary:2.44 testis:3.28 heart:2.54 muscle:2.95 esophagus:2.80 stomach:- intestine:2.64 colon:2.63     liver/hepato:2.58    lung:2.21 bladder:2.69 kidney:2.64 pituitary:2.74 thyroid/parathyroid:2.50 adrenal gland:- pancreas:2.41 breast:2.47 salivary:2.53
RNA-seq uterus:- placenta:- prostate:3.69 ovary:2.63 testis:3.32 heart:2.80 muscle:2.63 esophagus:- stomach:- intestine:- colon:2.94     liver/hepato:2.33        lung:1.68    bladder:- kidney:2.55 pituitary:- thyroid/parathyroid:2.70 adrenal gland:2.03 pancreas:- breast:2.48 salivary:-

Gene Information

IDs

Refseq ID NM_006859
Gene ID 11019
Unigene ID Hs.550502
Probe set ID 214045_at  [HG-U133_Plus_2]
Ensembl ID ENSG00000121897
GTEx ID ENSG00000121897

Orthologous Gene

Mouse[1]  NM_024471
Rat[1]  NM_001012037

Chromosomal Region

4p14  [39,460,620  -  39,479,273]

Gene Family (Interpro ID)

IPR006638  Elongator protein 3/MiaB/NifB
IPR003698  Lipoate synthase
IPR007197  Radical SAM

Link to Pubmed  (Pubmed ID)

11124703
11389890
12477932
15489334
17207965
18029348
19074983
20877624
22152680
24334290

Gene Ontology  (GO ID)

Biological Process

GO:0006954  inflammatory response
GO:0009107  lipoate biosynthetic process
GO:0001843  neural tube closure
GO:0009249  protein lipoylation
GO:0032496  response to lipopolysaccharide
GO:0006979  response to oxidative stress

Cellular Component

GO:0005739  mitochondrion

Molecular Function

GO:0051539  4 iron, 4 sulfur cluster binding
GO:0016992  lipoate synthase activity
GO:0046872  metal ion binding