receptor-interacting serine-threonine kinase 3

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Synonym

RIPK3, RIP-like protein kinase 3, Receptor-interacting protein 3, RIP-3, receptor-interacting serine-threonine kinase 3, RIP3

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:10.70 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:30 vein:- lymphnode:30.30 peripheral blood:291.50 spleen:359.20 thymus:64.40 bone marrow:19.70 adipose:40.30 bone:64 skin:19.20
GeneChip nodata
CAGE cerebrum:0.46 cerebellum:- brain stem:1.04 corpus callosum/glia:0.73 pineal gland:0.26 peripheral nerve:- spine:1.26 retina:- eye:- artery/aorta:1.16 vein:1.98 lymphnode:1.88 peripheral blood:- spleen:2.00 thymus:1.56 bone marrow:- adipose:1.74 bone:- skin:-
RNA-seq cerebrum:0.12 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:2.10 peripheral blood:- spleen:- thymus:- bone marrow:- adipose:1.63 bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:72.90 placenta:32.80 prostate:11.30 ovary:- testis:13 heart:25.50 muscle:- esophagus:- stomach:42.50 intestine:226.80 colon:50.90     liver/hepato:31.70        lung:48.90    bladder:628.10 kidney:10.40 pituitary:- thyroid/parathyroid:327.50 adrenal gland:- pancreas:8.90 breast:- salivary:328.40
GeneChip nodata
CAGE uterus:1.32 placenta:1.08 prostate:1.28 ovary:0.68 testis:0.64 heart:0.77 muscle:0.77 esophagus:1.59 stomach:- intestine:2.89 colon:2.20     liver/hepato:0.14    lung:1.65 bladder:0.95 kidney:0.98 pituitary:0.42 thyroid/parathyroid:1.34 adrenal gland:- pancreas:1.74 breast:1.16 salivary:0.83
RNA-seq uterus:- placenta:- prostate:1.44 ovary:0.62 testis:0.60 heart:0.77 muscle:0.47 esophagus:- stomach:- intestine:- colon:0.77     liver/hepato:0.60        lung:1.19    bladder:- kidney:1.17 pituitary:- thyroid/parathyroid:1.91 adrenal gland:2.15 pancreas:- breast:1.17 salivary:-

Gene Information

IDs

Refseq ID NM_006871
Gene ID 11035
Unigene ID Hs.268551
Probe set ID -
Ensembl ID ENSG00000129465
GTEx ID ENSG00000129465

Orthologous Gene

Mouse[3]  NM_001164107, NM_001164108, NM_019955
Rat [0]  

Chromosomal Region

14q12  [24,805,227  -  24,809,251]

Gene Family (Interpro ID)

IPR000719  Protein kinase, catalytic domain
IPR011009  Protein kinase-like domain
IPR002290  Serine/threonine-protein kinase domain
IPR017442  Serine/threonine-protein kinase-like domain
IPR001245  Tyrosine-protein kinase, catalytic domain
IPR020635  Tyrosine-protein kinase, subgroup, catalytic domain

Link to Pubmed  (Pubmed ID)

10339433
10358032
10818227
11734559
12477932
15064760
15208320
15814722
15896315
16344560
16429275
16844082
17114179
17827388
18025550
18442983
18533105
18941233
19524512
19524513
19590578
19690434
20354226
20413098
20618440
20634891
21052097
21153365
21894190
21903422
21931591
21988832
22421439
22817896
22864571
23071110
23612963
24314238
24322838
24703947

Gene Ontology  (GO ID)

Biological Process

GO:0032147  activation of protein kinase activity
GO:0007249  I-kappaB kinase/NF-kappaB cascade
GO:0006917  induction of apoptosis
GO:0045087  innate immune response
GO:0002756  MyD88-independent toll-like receptor signaling pathway
GO:0060545  positive regulation of necroptosis
GO:0051092  positive regulation of NF-kappaB transcription factor activity
GO:0032481  positive regulation of type I interferon production
GO:0051291  protein heterooligomerization
GO:0051260  protein homooligomerization
GO:0006464  protein modification process
GO:0007165  signal transduction
GO:0034138  toll-like receptor 3 signaling pathway
GO:0034142  toll-like receptor 4 signaling pathway
GO:0002224  toll-like receptor signaling pathway

Cellular Component

GO:0005829  cytosol
GO:0005739  mitochondrion
GO:0005886  plasma membrane

Molecular Function

GO:0005524  ATP binding
GO:0042802  identical protein binding
GO:0004704  NF-kappaB-inducing kinase activity
GO:0005515  protein binding
GO:0004672  protein kinase activity
GO:0004674  protein serine/threonine kinase activity
GO:0003713  transcription coactivator activity