Rap guanine nucleotide exchange factor (GEF) 4

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Synonym

RAP guanine-nucleotide-exchange factor (GEF) 4, Rap guanine nucleotide exchange factor (GEF) 4, Epac 2, cAMP-GEFII, Nbla00496, Rap guanine nucleotide exchange factor 4, CGEF2, EPAC2, CAMP-GEFII, RAPGEF4, Exchange factor directly activated by cAMP 2

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:218.10 cerebellum:63 brain stem:- corpus callosum/glia:29.20 pineal gland:- peripheral nerve:- spine:- retina:118.60 eye:23.50 artery/aorta:30 vein:- lymphnode:10.10 peripheral blood:- spleen:- thymus:25.80 bone marrow:19.70 adipose:- bone:- skin:9.60
GeneChip cerebrum:6.73 cerebellum:5.65 brain stem:5.48 corpus callosum/glia:4.70 pineal gland:- peripheral nerve:4.94 spine:4 retina:- eye:- artery/aorta:3.24 vein:3.11 lymphnode:3.30 peripheral blood:- spleen:2.54 thymus:2.90 bone marrow:2.70 adipose:3.40 bone:- skin:3.95
CAGE cerebrum:4.50 cerebellum:- brain stem:2.85 corpus callosum/glia:3.39 pineal gland:4.73 peripheral nerve:- spine:2.29 retina:- eye:- artery/aorta:2.10 vein:1.17 lymphnode:1.24 peripheral blood:- spleen:0.39 thymus:0.74 bone marrow:- adipose:2.80 bone:- skin:-
RNA-seq cerebrum:2.39 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:1.57 peripheral blood:- spleen:- thymus:- bone marrow:- adipose:1.92 bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:54.70 placenta:7.30 prostate:- ovary:- testis:21.60 heart:12.80 muscle:- esophagus:- stomach:21.20 intestine:- colon:17     liver/hepato:10.60        lung:24.40    bladder:- kidney:41.60 pituitary:- thyroid/parathyroid:327.50 adrenal gland:101.60 pancreas:97.80 breast:27.90 salivary:-
GeneChip uterus:3.55 placenta:2.49 prostate:3.73 ovary:3.78 testis:3.06 heart:3.58 muscle:3.04 esophagus:2.92 stomach:3.35 intestine:3.20 colon:2.91 liver/hepato:4.27 lung:4.16 bladder:- kidney:3.34 pituitary:4.08 thyroid/parathyroid:3.41 adrenal gland:6.92 pancreas:2.95 breast:3.40 salivary:2.65
CAGE uterus:3.14 placenta:0.99 prostate:2.24 ovary:2.08 testis:2.49 heart:2.07 muscle:1.57 esophagus:1.72 stomach:- intestine:1.35 colon:0.81     liver/hepato:2.46    lung:2.72 bladder:1.78 kidney:1.64 pituitary:2.72 thyroid/parathyroid:1.38 adrenal gland:- pancreas:1.74 breast:1.36 salivary:0.83
RNA-seq uterus:- placenta:- prostate:1.04 ovary:2.17 testis:1.52 heart:0.61 muscle:0.45 esophagus:- stomach:- intestine:- colon:1.63     liver/hepato:1.40        lung:3.61    bladder:- kidney:1.46 pituitary:- thyroid/parathyroid:1.23 adrenal gland:2.16 pancreas:- breast:1.50 salivary:-

Gene Information

IDs

Refseq ID NM_001100397
Gene ID 11069
Unigene ID Hs.470646
Probe set ID 205651_x_at  [HG-U133_Plus_2]
Ensembl ID ENSG00000091428
GTEx ID ENSG00000091428

Orthologous Gene

Mouse[2]  NM_001204165, NM_001204166, NM_001204167, NM_019688
Rat[2]  NM_001204165, NM_001204166, NM_001204167, NM_019688

Chromosomal Region

2q31.1  [173,600,002  -  173,917,621]

Gene Family (Interpro ID)

IPR000595  Cyclic nucleotide-binding
IPR018490  Cyclic nucleotide-binding-like
IPR000591  DEP domain
IPR014710  RmlC-like jelly roll fold
IPR011991  Winged helix repressor DNA-binding

Link to Pubmed  (Pubmed ID)

8889548
9789079
9856955
10777494
11056535
11438518
11598134
11707077
12384139
12469113
12477932
14593429
14660679
15202935
15489334
15856025
16713569
17284589
18495799
18854429
19086053
19401682
19553663
19598235
19739231
20200953
20233795
20379614
20663796
21454623
22363678
23804752
24169561
24586238
24722188

Gene Ontology  (GO ID)

Biological Process

GO:0007596  blood coagulation
GO:0017156  calcium ion-dependent exocytosis
GO:0019933  cAMP-mediated signaling
GO:0006112  energy reserve metabolic process
GO:0007186  G-protein coupled receptor protein signaling pathway
GO:0030073  insulin secretion
GO:0030168  platelet activation
GO:0017157  regulation of exocytosis
GO:0050796  regulation of insulin secretion
GO:0051056  regulation of small GTPase mediated signal transduction
GO:0007264  small GTPase mediated signal transduction

Cellular Component

GO:0005952  cAMP-dependent protein kinase complex
GO:0005829  cytosol
GO:0016020  membrane
GO:0005886  plasma membrane

Molecular Function

GO:0030552  cAMP binding
GO:0008603  cAMP-dependent protein kinase regulator activity
GO:0005085  guanyl-nucleotide exchange factor activity
GO:0005515  protein binding
GO:0017016  Ras GTPase binding
GO:0005088  Ras guanyl-nucleotide exchange factor activity