forkhead box N3

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Synonym

chromosome 14 open reading frame 116, Forkhead box protein N3, FOXN3, CHES1, C14orf116, Checkpoint suppressor 1, checkpoint suppressor 1, PRO1635

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:- cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:- peripheral blood:- spleen:- thymus:- bone marrow:- adipose:- bone:- skin:-
GeneChip cerebrum:6.77 cerebellum:6.63 brain stem:6.88 corpus callosum/glia:6.57 pineal gland:- peripheral nerve:6.78 spine:6.65 retina:- eye:- artery/aorta:6.91 vein:7.09 lymphnode:6.31 peripheral blood:- spleen:6.24 thymus:6.36 bone marrow:7 adipose:6.90 bone:- skin:6.69
CAGE cerebrum:3.49 cerebellum:- brain stem:3.58 corpus callosum/glia:3.86 pineal gland:4.17 peripheral nerve:- spine:3.72 retina:- eye:- artery/aorta:4.78 vein:4.09 lymphnode:4.13 peripheral blood:- spleen:3.67 thymus:4.41 bone marrow:- adipose:4.35 bone:- skin:-
RNA-seq cerebrum:2.12 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:3.56 peripheral blood:- spleen:- thymus:- bone marrow:- adipose:4.43 bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:- placenta:- prostate:- ovary:- testis:- heart:- muscle:- esophagus:- stomach:- intestine:- colon:-     liver/hepato:-        lung:-    bladder:- kidney:- pituitary:- thyroid/parathyroid:- adrenal gland:- pancreas:- breast:- salivary:-
GeneChip uterus:6.29 placenta:6.64 prostate:6.29 ovary:6.15 testis:6.49 heart:7.35 muscle:7.32 esophagus:6.34 stomach:6.57 intestine:6.82 colon:7.05 liver/hepato:6.89 lung:6.45 bladder:- kidney:6.77 pituitary:6.67 thyroid/parathyroid:6.17 adrenal gland:6.49 pancreas:6.48 breast:6.37 salivary:6.61
CAGE uterus:3.83 placenta:3.27 prostate:3.93 ovary:3.98 testis:3.58 heart:4.20 muscle:4.30 esophagus:3.93 stomach:- intestine:4.52 colon:4.34     liver/hepato:3.46    lung:4.05 bladder:4.17 kidney:2.85 pituitary:3.37 thyroid/parathyroid:2.91 adrenal gland:- pancreas:3.78 breast:4.72 salivary:2.93
RNA-seq uterus:- placenta:- prostate:3.98 ovary:3.28 testis:3.76 heart:4.08 muscle:4.40 esophagus:- stomach:- intestine:- colon:4.03     liver/hepato:2.93        lung:2.91    bladder:- kidney:2.57 pituitary:- thyroid/parathyroid:2.78 adrenal gland:3.43 pancreas:- breast:4.64 salivary:-

Gene Information

IDs

Refseq ID NM_001085471
Gene ID 1112
Unigene ID Hs.621371
Probe set ID 205021_s_at  [HG-U133_Plus_2]
Ensembl ID ENSG00000053254
GTEx ID ENSG00000053254

Orthologous Gene

Mouse[2]  NM_183186
Rat[1]  NM_001108047

Chromosomal Region

14q32.11  [89,591,215  -  90,085,493]

Gene Family (Interpro ID)

IPR001766  Transcription factor, fork head
IPR011991  Winged helix repressor DNA-binding

Link to Pubmed  (Pubmed ID)

8125298
8617492
8889549
9154802
11483580
12477932
12508121
14702039
15231747
15342556
15489334
16102918
16951149
17983802
18074379
19322201
19609547
20379614
20634891
20691664
22581228
23133627
23602568
23643386

Gene Ontology  (GO ID)

Biological Process

GO:0000077  DNA damage checkpoint
GO:0009790  embryonic development
GO:0000085  G2 phase of mitotic cell cycle
GO:0045892  negative regulation of transcription, DNA-dependent
GO:0007389  pattern specification process
GO:0051090  regulation of transcription factor activity
GO:0009888  tissue development

Cellular Component

GO:0005634  nucleus
GO:0005667  transcription factor complex

Molecular Function

GO:0008301  DNA bending activity
GO:0003690  double-stranded DNA binding
GO:0005515  protein binding
GO:0008022  protein C-terminus binding
GO:0003705  RNA polymerase II transcription factor activity, enhancer binding
GO:0043565  sequence-specific DNA binding
GO:0008134  transcription factor binding