adenylate cyclase activating polypeptide 1 (pituitary) receptor type I

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Synonym

PACAP type I receptor, PAC1-R, PACAP-R-1, ADCYAP1R1, TPS-A, PACAPRI, PACAPR

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:119.70 cerebellum:63 brain stem:- corpus callosum/glia:29.20 pineal gland:- peripheral nerve:61.30 spine:112.30 retina:- eye:11.80 artery/aorta:- vein:- lymphnode:- peripheral blood:- spleen:- thymus:- bone marrow:39.40 adipose:- bone:- skin:-
GeneChip cerebrum:4.88 cerebellum:5.07 brain stem:4.84 corpus callosum/glia:4.80 pineal gland:- peripheral nerve:4.96 spine:4.91 retina:- eye:- artery/aorta:4.88 vein:4.87 lymphnode:4.90 peripheral blood:- spleen:4.63 thymus:4.77 bone marrow:4.94 adipose:5.03 bone:- skin:4.93
CAGE cerebrum:3.67 cerebellum:- brain stem:3.57 corpus callosum/glia:3.65 pineal gland:2.46 peripheral nerve:- spine:3.26 retina:- eye:- artery/aorta:0.59 vein:1.17 lymphnode:0.77 peripheral blood:- spleen:0.17 thymus:0.18 bone marrow:- adipose:1.16 bone:- skin:-
RNA-seq cerebrum:0.46 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:0 peripheral blood:- spleen:- thymus:- bone marrow:- adipose:0 bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:18.20 placenta:3.60 prostate:- ovary:- testis:8.70 heart:12.80 muscle:- esophagus:- stomach:- intestine:- colon:8.50     liver/hepato:-        lung:9.80    bladder:- kidney:- pituitary:- thyroid/parathyroid:- adrenal gland:- pancreas:- breast:- salivary:-
GeneChip uterus:4.63 placenta:4.82 prostate:4.47 ovary:4.58 testis:4.60 heart:4.84 muscle:5.11 esophagus:4.78 stomach:4.77 intestine:4.70 colon:4.85 liver/hepato:4.77 lung:4.67 bladder:- kidney:4.86 pituitary:4.84 thyroid/parathyroid:4.64 adrenal gland:4.66 pancreas:5.10 breast:4.62 salivary:4.86
CAGE uterus:2.17 placenta:0.08 prostate:1.30 ovary:1.68 testis:1.15 heart:1.44 muscle:0.05 esophagus:1.14 stomach:- intestine:1.22 colon:1.67     liver/hepato:0.14    lung:0.59 bladder:0.87 kidney:0 pituitary:1.77 thyroid/parathyroid:0.32 adrenal gland:- pancreas:0 breast:1.68 salivary:1.00
RNA-seq uterus:- placenta:- prostate:0.07 ovary:0.00 testis:0 heart:0 muscle:0 esophagus:- stomach:- intestine:- colon:0.04     liver/hepato:0        lung:0    bladder:- kidney:0 pituitary:- thyroid/parathyroid:0 adrenal gland:0 pancreas:- breast:0.02 salivary:-

Gene Information

IDs

Refseq ID NM_001118885
Gene ID 117
Unigene ID Hs.377783
Probe set ID 207462_at  [HG-U133_Plus_2]
Ensembl ID ENSG00000101958
GTEx ID ENSG00000101958

Orthologous Gene

Mouse[1]  NM_183427
Rat [0]  

Chromosomal Region

7p14.3  [31,092,076  -  31,151,089]

Gene Family (Interpro ID)

IPR000832  GPCR, family 2, secretin-like
IPR001571  GPCR, family 2, vasoactive intestinal peptide receptor
IPR001771  GPCR, family 2, vasoactive intestinal peptide receptor 1
IPR002284  GPCR, family 2, vasoactive intestinal peptide receptor 2
IPR017981  GPCR, family 2-like

Link to Pubmed  (Pubmed ID)

7851900
7902709
8253796
8663363
8703026
8770902
8933357
8954788
9543159
10235634
10562300
10583729
10698193
10764955
11930171
11959368
12036966
12409223
12409233
12477932
12573802
12690205
12732341
12948842
14702039
14742913
15518890
15670850
16226889
16344560
16372333
16401644
16572459
16805430
16823490
16888199
16939974
17470806
18240029
18353507
18577758
19086053
19269029
19926922
20026142
20395540
21185349
21350482
21621269
21912390
22539193
22581436
22609358
22776899
22961270
23147486
23280952
23328528
23394710
23505260
23818986
24220567
24516127
24696141

Gene Ontology  (GO ID)

Biological Process

GO:0007190  activation of adenylate cyclase activity
GO:0007202  activation of phospholipase C activity
GO:0019933  cAMP-mediated signaling
GO:0030154  cell differentiation
GO:0007166  cell surface receptor linked signal transduction
GO:0046545  development of primary female sexual characteristics
GO:0033555  multicellular organismal response to stress
GO:0060548  negative regulation of cell death
GO:0048011  nerve growth factor receptor signaling pathway
GO:0010524  positive regulation of calcium ion transport into cytosol
GO:0060732  positive regulation of inositol phosphate biosynthetic process
GO:0042493  response to drug
GO:0032355  response to estradiol stimulus
GO:0045471  response to ethanol
GO:0007283  spermatogenesis
GO:0007169  transmembrane receptor protein tyrosine kinase signaling pathway

Cellular Component

GO:0005901  caveola
GO:0009986  cell surface
GO:0005768  endosome
GO:0005887  integral to plasma membrane
GO:0043005  neuron projection
GO:0005886  plasma membrane
GO:0005791  rough endoplasmic reticulum
GO:0005923  tight junction

Molecular Function

GO:0008179  adenylate cyclase binding
GO:0030306  ADP-ribosylation factor binding
GO:0042923  neuropeptide binding
GO:0005515  protein binding
GO:0004872  receptor activity
GO:0004999  vasoactive intestinal polypeptide receptor activity