chloride channel 6

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Synonym

chloride channel 6, KIAA0046, CLC-6, Chloride channel protein 6, CLCN6, ClC-6

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:66.40 cerebellum:88.20 brain stem:- corpus callosum/glia:58.30 pineal gland:- peripheral nerve:- spine:336.90 retina:118.60 eye:47 artery/aorta:- vein:- lymphnode:40.40 peripheral blood:- spleen:18.90 thymus:38.70 bone marrow:78.70 adipose:40.30 bone:- skin:72
GeneChip cerebrum:6.96 cerebellum:6.43 brain stem:7.25 corpus callosum/glia:6.82 pineal gland:- peripheral nerve:7.21 spine:6.96 retina:- eye:- artery/aorta:6.02 vein:5.94 lymphnode:6.04 peripheral blood:- spleen:5.99 thymus:5.53 bone marrow:5.73 adipose:5.99 bone:- skin:5.94
CAGE cerebrum:3.14 cerebellum:- brain stem:3.40 corpus callosum/glia:3.42 pineal gland:2.88 peripheral nerve:- spine:3.22 retina:- eye:- artery/aorta:2.43 vein:1.92 lymphnode:2.08 peripheral blood:- spleen:1.99 thymus:1.77 bone marrow:- adipose:2.43 bone:- skin:-
RNA-seq cerebrum:0.00 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:0.21 peripheral blood:- spleen:- thymus:- bone marrow:- adipose:0.02 bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:72.90 placenta:40.10 prostate:33.80 ovary:37.30 testis:99.50 heart:38.30 muscle:- esophagus:- stomach:42.50 intestine:32.40 colon:33.90     liver/hepato:-        lung:14.70    bladder:125.60 kidney:20.80 pituitary:- thyroid/parathyroid:- adrenal gland:- pancreas:53.30 breast:46.50 salivary:-
GeneChip uterus:5.95 placenta:5.59 prostate:5.82 ovary:5.95 testis:6.08 heart:6.02 muscle:6.19 esophagus:5.60 stomach:5.62 intestine:5.59 colon:5.58 liver/hepato:6.01 lung:5.89 bladder:- kidney:6.15 pituitary:6.31 thyroid/parathyroid:6.13 adrenal gland:6.34 pancreas:5.92 breast:5.97 salivary:5.48
CAGE uterus:2.51 placenta:1.96 prostate:2.22 ovary:2.33 testis:2.04 heart:2.35 muscle:2.05 esophagus:1.50 stomach:- intestine:2.34 colon:2.39     liver/hepato:1.47    lung:2.25 bladder:2.16 kidney:1.77 pituitary:2.73 thyroid/parathyroid:2.01 adrenal gland:- pancreas:1.98 breast:2.41 salivary:2.01
RNA-seq uterus:- placenta:- prostate:0.18 ovary:0.32 testis:0.22 heart:0.00 muscle:0.00 esophagus:- stomach:- intestine:- colon:0.02     liver/hepato:0.00        lung:0.00    bladder:- kidney:0.00 pituitary:- thyroid/parathyroid:0.38 adrenal gland:0.48 pancreas:- breast:0.04 salivary:-

Gene Information

IDs

Refseq ID NM_021736
Gene ID 1185
Unigene ID Hs.193043
Probe set ID 203950_s_at  [HG-U133_Plus_2]
Ensembl ID ENSG00000011021
GTEx ID ENSG00000011021

Orthologous Gene

Mouse[1]  NM_011929
Rat[1]  NM_001106479

Chromosomal Region

1p36.22  [11,866,207  -  11,903,201]

Gene Family (Interpro ID)

IPR002248  Chloride channel CLC-6
IPR001807  Chloride channel, voltage gated

Link to Pubmed  (Pubmed ID)

7584044
8543009
9224655
9565675
10198195
10500249
11306429
12168954
12370778
12477932
15489334
16344560
16710414
16751776
17534424
17897319
19430483
19729601
19898482
19913121
20379614
20416077
20466723
20628086
21060006
21273288
21890473
23000965

Gene Ontology  (GO ID)

Biological Process

GO:0006884  cell volume homeostasis
GO:0006821  chloride transport
GO:0034220  ion transmembrane transport
GO:0007165  signal transduction
GO:0055085  transmembrane transport

Cellular Component

GO:0010008  endosome membrane
GO:0016021  integral to membrane

Molecular Function

GO:0015297  antiporter activity
GO:0005524  ATP binding
GO:0005247  voltage-gated chloride channel activity