adrenergic, alpha-1A-, receptor

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Synonym

ADRA1C, Alpha-1C adrenergic receptor, Alpha 1A-adrenoceptor, ADRA1L1, adrenergic, alpha-1A-, receptor, Alpha-1A adrenergic receptor, Alpha 1A-adrenoreceptor, ALPHA1AAR, alpha-1A-, Alpha adrenergic receptor 1c, ADRA1A, alpha1A-AR

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST nodata
GeneChip cerebrum:3.65 cerebellum:3.52 brain stem:3.67 corpus callosum/glia:3.58 pineal gland:- peripheral nerve:3.53 spine:3.58 retina:- eye:- artery/aorta:3.54 vein:3.71 lymphnode:3.62 peripheral blood:- spleen:3.60 thymus:3.38 bone marrow:3.67 adipose:3.67 bone:- skin:3.68
CAGE cerebrum:1.03 cerebellum:- brain stem:1.02 corpus callosum/glia:1.47 pineal gland:1.75 peripheral nerve:- spine:0.80 retina:- eye:- artery/aorta:0.47 vein:0.18 lymphnode:0.44 peripheral blood:- spleen:1.26 thymus:0 bone marrow:- adipose:0.71 bone:- skin:-
RNA-seq cerebrum:0.48 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:0.50 peripheral blood:- spleen:- thymus:- bone marrow:- adipose:0.40 bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST nodata
GeneChip uterus:3.59 placenta:3.57 prostate:3.48 ovary:3.54 testis:3.49 heart:3.83 muscle:3.97 esophagus:3.55 stomach:3.70 intestine:3.77 colon:3.89 liver/hepato:4.16 lung:3.52 bladder:- kidney:3.79 pituitary:3.46 thyroid/parathyroid:3.39 adrenal gland:3.54 pancreas:3.82 breast:3.49 salivary:3.88
CAGE uterus:0.41 placenta:0 prostate:0.58 ovary:0.07 testis:0.16 heart:0.68 muscle:0.25 esophagus:0 stomach:- intestine:0.07 colon:0.18     liver/hepato:3.01    lung:0.21 bladder:0.09 kidney:0.21 pituitary:0.10 thyroid/parathyroid:0.12 adrenal gland:- pancreas:0 breast:0 salivary:1.95
RNA-seq uterus:- placenta:- prostate:0.24 ovary:0.20 testis:0.09 heart:0.87 muscle:0.00 esophagus:- stomach:- intestine:- colon:0.13     liver/hepato:1.58        lung:0.55    bladder:- kidney:0.17 pituitary:- thyroid/parathyroid:0.39 adrenal gland:0.26 pancreas:- breast:1.50 salivary:-

Gene Information

IDs

Refseq ID NM_000680
Gene ID 148
Unigene ID -
Probe set ID 211492_s_at  [HG-U133_Plus_2]
Ensembl ID ENSG00000120907
GTEx ID ENSG00000120907

Orthologous Gene

Mouse[1]  NM_013461
Rat [0]  

Chromosomal Region

8p21.2  [26,605,667  -  26,724,790]

Gene Family (Interpro ID)

IPR000276  7TM GPCR, rhodopsin-like
IPR002233  Adrenergic receptor
IPR001004  Adrenergic receptor, alpha 1C subtype
IPR017452  GPCR, rhodopsin-like superfamily

Link to Pubmed  (Pubmed ID)

1363873
1970822
7737411
7805763
7815325
8024574
8183249
8396931
8564208
8832064
9359081
9490024
10334511
10493934
10587338
10671514
10860850
11154706
11425010
12184796
12409310
12477932
12519093
12544508
12707939
12782672
14626446
15136785
15179408
15297446
15474515
15525470
15626751
15824464
15917235
15946947
16043131
16153395
16536786
16633140
16645408
16685204
16690783
16754659
16823803
17075692
17408692
17556657
17655760
17681068
17972277
17973108
18240029
18257748
18331634
18351393
18413308
18523139
18524654
18821565
18996102
19011682
19086053
19095219
19102884
19105822
19322003
19352218
19444285
19476811
19520158
19565482
19730237
19763272
19874574
19913121
19918262
19919991
20004544
20044737
20129829
20173430
20379614
20628086
20705341
21063774
21223784
21262225
21519279
21571945
21738688
21792097
21982020
22037178
22089237
22091949
22952603
23460120
23717684
23877383
23902938

Gene Ontology  (GO ID)

Biological Process

GO:0007202  activation of phospholipase C activity
GO:0007200  activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger
GO:0007512  adult heart development
GO:0007568  aging
GO:0006915  apoptosis
GO:0060402  calcium ion transport into cytosol
GO:0016049  cell growth
GO:0007267  cell-cell signaling
GO:0007204  elevation of cytosolic calcium ion concentration
GO:0007186  G-protein coupled receptor protein signaling pathway
GO:0060073  micturition
GO:0008285  negative regulation of cell proliferation
GO:0001985  negative regulation of heart rate involved in baroreceptor response to increased systemic arterial blood pressure
GO:0035024  negative regulation of Rho protein signal transduction
GO:0032229  negative regulation of synaptic transmission, GABAergic
GO:0001994  norepinephrine-epinephrine vasoconstriction involved in regulation of systemic arterial blood pressure
GO:0035265  organ growth
GO:0045760  positive regulation of action potential
GO:0060452  positive regulation of cardiac muscle contraction
GO:0070374  positive regulation of ERK1 and ERK2 cascade
GO:0001996  positive regulation of heart rate by epinephrine-norepinephrine
GO:0043410  positive regulation of MAPKKK cascade
GO:0090037  positive regulation of protein kinase C signaling cascade
GO:0045987  positive regulation of smooth muscle contraction
GO:0003084  positive regulation of systemic arterial blood pressure
GO:0001997  positive regulation of the force of heart contraction by epinephrine-norepinephrine
GO:0045907  positive regulation of vasoconstriction
GO:0007243  protein kinase cascade
GO:0042493  response to drug
GO:0009725  response to hormone stimulus
GO:0006950  response to stress
GO:0007165  signal transduction
GO:0006939  smooth muscle contraction

Cellular Component

GO:0005887  integral to plasma membrane
GO:0031965  nuclear membrane
GO:0005634  nucleus
GO:0005886  plasma membrane
GO:0030315  T-tubule
GO:0030018  Z disc

Molecular Function

GO:0004937  alpha1-adrenergic receptor activity
GO:0046982  protein heterodimerization activity