cytochrome P450, family 11, subfamily B, polypeptide 2

Synonym

P450aldo, Aldosterone-synthesizing enzyme, Steroid 18-hydroxylase, P450C18, CYP11B, P-450C18, subfamily XIB (steroid 11-beta-hydroxylase), CYP11B2, CYP11BL, P-450Aldo, ALDOS, Cytochrome P450 11B2, mitochondrial precursor, Aldosterone synthase, CYPXIB2

normal 40 tissues
cell lines, primary cells, adult tissues and fetal tissues (FANTOM5 CAGE)

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain

blood

connective

EST

cerebrum:-

cerebellum:-

brain stem:-

corpus callosum/glia:-

pineal gland:-

peripheral nerve:-

spine:-

retina:-

eye:-

artery/aorta:-

vein:-

lymphnode:-

peripheral blood:-

spleen:-

thymus:-

bone marrow:-

adipose:-

bone:-

skin:-

GeneChip

cerebrum:6.70

cerebellum:6.84

brain stem:6.77

corpus callosum/glia:6.73

pineal gland:-

peripheral nerve:6

spine:6.34

retina:-

eye:-

artery/aorta:6.12

vein:6.73

lymphnode:6.30

peripheral blood:-

spleen:6.26

thymus:5.62

bone marrow:6.39

adipose:6.31

bone:-

skin:5.95

CAGE

nodata

RNA-seq

cerebrum:0

cerebellum:-

brain stem:-

corpus callosum/glia:-

pineal gland:-

peripheral nerve:-

spine:-

retina:-

eye:-

artery/aorta:-

vein:-

lymphnode:0

peripheral blood:-

spleen:-

thymus:-

bone marrow:-

adipose:0

bone:-

skin:-

reproductive

muscular

alimentary

liver

lung

urinary

endo/exo-crine

EST

uterus:-

placenta:-

prostate:-

ovary:-

testis:-

heart:-

muscle:-

esophagus:-

stomach:-

intestine:-

colon:-

liver/hepato:-

lung:-

bladder:-

kidney:-

pituitary:-

thyroid/parathyroid:-

adrenal gland:101.60

pancreas:-

breast:-

salivary:-

GeneChip

uterus:6.17

placenta:6.07

prostate:5.69

ovary:6.42

testis:5.72

heart:6.76

muscle:6.89

esophagus:6.46

stomach:6.46

intestine:6.33

colon:6.86

liver/hepato:6.66

lung:6.38

bladder:-

kidney:6.64

pituitary:6.40

thyroid/parathyroid:6.15

adrenal gland:9.13

pancreas:6.91

breast:6.07

salivary:6.64

CAGE

nodata

RNA-seq

uterus:-

placenta:-

prostate:0

ovary:0

testis:0.05

heart:0

muscle:0

esophagus:-

stomach:-

intestine:-

colon:0

liver/hepato:0

lung:0

bladder:-

kidney:0

pituitary:-

thyroid/parathyroid:0

adrenal gland:0

pancreas:-

breast:0

salivary:-

IDs

Refseq ID	NM_000498
Gene ID	1585
Unigene ID	Hs.632054
Probe set ID	214630_at [HG-U133_Plus_2]
Ensembl ID	ENSG00000179142
GTEx ID	ENSG00000179142

Orthologous Gene

Mouse [0]
Rat [0]

Chromosomal Region

8q24.3 [143,991,975 - 143,999,259]

Search genes near this gene
- Between -5kb and +5kb
- Between -10kb and +10kb

Gene Family (Interpro ID)

IPR001128	Cytochrome P450
IPR002397	Cytochrome P450, B-class
IPR002401	Cytochrome P450, E-class, group I
IPR002403	Cytochrome P450, E-class, group IV

Gene Ontology (GO ID)

Biological Process

GO:0032342	aldosterone biosynthetic process
GO:0006700	C21-steroid hormone biosynthetic process
GO:0032870	cellular response to hormone stimulus
GO:0034651	cortisol biosynthetic process
GO:0006705	mineralocorticoid biosynthetic process
GO:0055075	potassium ion homeostasis
GO:0002017	regulation of blood volume by renal aldosterone
GO:0003091	renal water homeostasis
GO:0055078	sodium ion homeostasis
GO:0008202	steroid metabolic process
GO:0016125	sterol metabolic process
GO:0006805	xenobiotic metabolic process

Cellular Component

GO:0005743	mitochondrial inner membrane
GO:0005739	mitochondrion

Molecular Function

GO:0047783	corticosterone 18-monooxygenase activity
GO:0009055	electron carrier activity
GO:0020037	heme binding
GO:0005506	iron ion binding
GO:0004507	steroid 11-beta-monooxygenase activity

cytochrome P450, family 11, subfamily B, polypeptide 2

Synonym

Expression Pattern

Choropleth map on BodyParts3D

Classification in 40 Organs

Gene Information

IDs

Orthologous Gene

Chromosomal Region

Gene Family (Interpro ID)

Link to Pubmed (Pubmed ID)

Gene Ontology (GO ID)

Biological Process

Cellular Component

Molecular Function