distal-less homeobox 1

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Synonym

distal-less homeo box 1, Homeobox protein DLX-1, DLX1, distal-less homeobox 1

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:29.60 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:5.90 artery/aorta:30 vein:- lymphnode:- peripheral blood:- spleen:- thymus:- bone marrow:- adipose:- bone:12.80 skin:-
GeneChip nodata
CAGE cerebrum:1.79 cerebellum:- brain stem:0.15 corpus callosum/glia:0.76 pineal gland:0.21 peripheral nerve:- spine:0 retina:- eye:- artery/aorta:0.34 vein:0.18 lymphnode:0 peripheral blood:- spleen:0.09 thymus:0 bone marrow:- adipose:0.14 bone:- skin:-
RNA-seq cerebrum:1.40 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:0.05 peripheral blood:- spleen:- thymus:- bone marrow:- adipose:0.03 bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:- placenta:- prostate:- ovary:- testis:- heart:- muscle:- esophagus:- stomach:- intestine:- colon:-     liver/hepato:-        lung:-    bladder:- kidney:- pituitary:- thyroid/parathyroid:- adrenal gland:- pancreas:- breast:- salivary:-
GeneChip nodata
CAGE uterus:0.15 placenta:0 prostate:0.49 ovary:0.20 testis:0.12 heart:0.14 muscle:0 esophagus:0.18 stomach:- intestine:0.21 colon:0.08     liver/hepato:0    lung:0.05 bladder:0.26 kidney:0 pituitary:0 thyroid/parathyroid:0.79 adrenal gland:- pancreas:0 breast:0 salivary:0
RNA-seq uterus:- placenta:- prostate:0.53 ovary:0.00 testis:0.00 heart:0.02 muscle:0 esophagus:- stomach:- intestine:- colon:0.51     liver/hepato:0        lung:0    bladder:- kidney:0 pituitary:- thyroid/parathyroid:0.27 adrenal gland:0.00 pancreas:- breast:0.00 salivary:-

Gene Information

IDs

Refseq ID NM_178120
Gene ID 1745
Unigene ID Hs.407015
Probe set ID -
Ensembl ID ENSG00000144355
GTEx ID ENSG00000144355

Orthologous Gene

Mouse[2]  NM_010053
Rat[1]  NM_001100531

Chromosomal Region

2q31.1  [172,949,468  -  172,954,405]

Gene Family (Interpro ID)

IPR001356  Homeobox
IPR009057  Homeodomain-like
IPR012287  Homeodomain-related

Link to Pubmed  (Pubmed ID)

7907794
12050665
12477932
14671321
14702039
14769946
15489334
16266434
18384059
18728693
19058789
19453261
20634891
21357706
22984994
23312518
23535729
24722188

Gene Ontology  (GO ID)

Biological Process

GO:0021893  cerebral cortex GABAergic interneuron fate commitment
GO:0048706  embryonic skeletal system development
GO:0021766  hippocampus development
GO:0007275  multicellular organismal development
GO:0043524  negative regulation of neuron apoptosis
GO:0048715  negative regulation of oligodendrocyte differentiation
GO:0000122  negative regulation of transcription from RNA polymerase II promoter
GO:0042475  odontogenesis of dentine-containing tooth
GO:0009954  proximal/distal pattern formation
GO:0021882  regulation of transcription from RNA polymerase II promoter involved in forebrain neuron fate commitment

Cellular Component

GO:0005634  nucleus

Molecular Function

GO:0003682  chromatin binding
GO:0003677  DNA binding
GO:0003700  transcription factor activity