distal-less homeobox 2

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Synonym

distal-less homeobox 2, TES1, distal-less homeo box 2, DLX2, TES-1, Homeobox protein DLX-2

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:2.40 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:29.40 artery/aorta:- vein:- lymphnode:- peripheral blood:- spleen:- thymus:- bone marrow:- adipose:- bone:- skin:9.60
GeneChip cerebrum:6.09 cerebellum:6.27 brain stem:6.14 corpus callosum/glia:6.21 pineal gland:- peripheral nerve:5.87 spine:5.75 retina:- eye:- artery/aorta:5.81 vein:6.25 lymphnode:5.94 peripheral blood:- spleen:5.92 thymus:5.57 bone marrow:6.27 adipose:5.98 bone:- skin:5.75
CAGE cerebrum:1.62 cerebellum:- brain stem:0.19 corpus callosum/glia:0.94 pineal gland:0.21 peripheral nerve:- spine:0 retina:- eye:- artery/aorta:0.79 vein:0 lymphnode:0.03 peripheral blood:- spleen:0.09 thymus:0.88 bone marrow:- adipose:0 bone:- skin:-
RNA-seq cerebrum:0.66 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:0.10 peripheral blood:- spleen:- thymus:- bone marrow:- adipose:0.02 bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:- placenta:- prostate:- ovary:- testis:21.60 heart:- muscle:- esophagus:- stomach:- intestine:- colon:25.40     liver/hepato:10.60        lung:-    bladder:- kidney:20.80 pituitary:- thyroid/parathyroid:- adrenal gland:- pancreas:- breast:- salivary:-
GeneChip uterus:5.67 placenta:5.92 prostate:5.33 ovary:5.86 testis:5.60 heart:6.43 muscle:6.27 esophagus:5.90 stomach:6.06 intestine:6.26 colon:6.45 liver/hepato:6.01 lung:6.10 bladder:- kidney:6.03 pituitary:5.66 thyroid/parathyroid:5.53 adrenal gland:5.84 pancreas:6.37 breast:5.57 salivary:6.25
CAGE uterus:0.13 placenta:0.16 prostate:0.58 ovary:0 testis:1.02 heart:0.15 muscle:0 esophagus:0.18 stomach:- intestine:0.14 colon:0.12     liver/hepato:0    lung:0 bladder:0.18 kidney:0.08 pituitary:0.19 thyroid/parathyroid:0.82 adrenal gland:- pancreas:0 breast:0.55 salivary:0
RNA-seq uterus:- placenta:- prostate:0.04 ovary:0 testis:0.10 heart:0.00 muscle:0 esophagus:- stomach:- intestine:- colon:0.01     liver/hepato:0        lung:0    bladder:- kidney:0 pituitary:- thyroid/parathyroid:0.13 adrenal gland:0.01 pancreas:- breast:0.03 salivary:-

Gene Information

IDs

Refseq ID NM_004405
Gene ID 1746
Unigene ID Hs.419126
Probe set ID 215685_s_at  [HG-U133_Plus_2]
Ensembl ID ENSG00000115844
GTEx ID ENSG00000115844

Orthologous Gene

Mouse[1]  NM_010054
Rat [0]  

Chromosomal Region

2q31.1  [172,964,167  -  172,967,628]

Gene Family (Interpro ID)

IPR001356  Homeobox
IPR009057  Homeodomain-like
IPR012287  Homeodomain-related

Link to Pubmed  (Pubmed ID)

1354641
7590232
7901126
7907794
8812481
9111364
11279128
11675124
12477932
12957859
15489334
15576338
15751970
18728693
19018235
19453261
20634891
21108812
21357706
21890473
21917150
21988832
23312518
23331016
23535729
23674878
24722188

Gene Ontology  (GO ID)

Biological Process

GO:0007420  brain development
GO:0048755  branching morphogenesis of a nerve
GO:0051216  cartilage development
GO:0021893  cerebral cortex GABAergic interneuron fate commitment
GO:0048701  embryonic cranial skeleton morphogenesis
GO:0021766  hippocampus development
GO:0048715  negative regulation of oligodendrocyte differentiation
GO:0000122  negative regulation of transcription from RNA polymerase II promoter
GO:0042475  odontogenesis of dentine-containing tooth
GO:0021772  olfactory bulb development
GO:0045944  positive regulation of transcription from RNA polymerase II promoter
GO:0009954  proximal/distal pattern formation
GO:0021882  regulation of transcription from RNA polymerase II promoter involved in forebrain neuron fate commitment

Cellular Component

GO:0005634  nucleus

Molecular Function

GO:0003682  chromatin binding
GO:0003727  single-stranded RNA binding
GO:0003700  transcription factor activity