DNA replication helicase 2 homolog (yeast)

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Synonym

KIAA0083, FLJ10063, DNA2L, DNA2-like homolog, MGC133297, DNA2 DNA replication helicase 2-like (yeast)

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:3.60 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:131.40 peripheral blood:- spleen:- thymus:51.50 bone marrow:39.40 adipose:- bone:- skin:28.80
GeneChip cerebrum:4.10 cerebellum:4.08 brain stem:4.18 corpus callosum/glia:4.17 pineal gland:- peripheral nerve:3.78 spine:3.93 retina:- eye:- artery/aorta:3.78 vein:4.02 lymphnode:4.08 peripheral blood:- spleen:3.86 thymus:5.76 bone marrow:4.91 adipose:3.88 bone:- skin:3.77
CAGE cerebrum:0.28 cerebellum:- brain stem:0.22 corpus callosum/glia:0.24 pineal gland:0.35 peripheral nerve:- spine:0.13 retina:- eye:- artery/aorta:0.18 vein:1.57 lymphnode:1.55 peripheral blood:- spleen:1.24 thymus:3.18 bone marrow:- adipose:0.36 bone:- skin:-
RNA-seq cerebrum:0.52 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:1.24 peripheral blood:- spleen:- thymus:- bone marrow:- adipose:0.23 bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:- placenta:3.60 prostate:- ovary:- testis:4.30 heart:- muscle:- esophagus:- stomach:42.50 intestine:- colon:33.90     liver/hepato:10.60        lung:9.80    bladder:- kidney:20.80 pituitary:116 thyroid/parathyroid:- adrenal gland:- pancreas:- breast:27.90 salivary:-
GeneChip uterus:4.06 placenta:3.81 prostate:4.22 ovary:3.89 testis:4.26 heart:3.99 muscle:4.08 esophagus:3.84 stomach:4.12 intestine:4.05 colon:4.28 liver/hepato:4.11 lung:3.93 bladder:- kidney:4.17 pituitary:3.98 thyroid/parathyroid:3.68 adrenal gland:3.86 pancreas:3.99 breast:3.85 salivary:4.04
CAGE uterus:0.61 placenta:0.99 prostate:0.39 ovary:0.26 testis:1.60 heart:0.04 muscle:0 esophagus:0.94 stomach:- intestine:1.22 colon:1.39     liver/hepato:0    lung:0.90 bladder:0 kidney:0.27 pituitary:0.10 thyroid/parathyroid:0.28 adrenal gland:- pancreas:0 breast:0.55 salivary:0
RNA-seq uterus:- placenta:- prostate:0.59 ovary:0.42 testis:1.29 heart:0.23 muscle:0.37 esophagus:- stomach:- intestine:- colon:0.49     liver/hepato:0.39        lung:0.53    bladder:- kidney:0.97 pituitary:- thyroid/parathyroid:0.39 adrenal gland:0.46 pancreas:- breast:0.60 salivary:-

Gene Information

IDs

Refseq ID NM_001080449
Gene ID 1763
Unigene ID Hs.532446
Probe set ID 213647_at  [HG-U133_Plus_2]
Ensembl ID ENSG00000138346
GTEx ID ENSG00000138346

Orthologous Gene

Mouse[1]  NM_177372
Rat[1]  NM_177372

Chromosomal Region

10q21.3  [70,173,821  -  70,231,879]

Gene Family (Interpro ID)

-

Link to Pubmed  (Pubmed ID)

7788527
8938459
11473323
12477932
15164054
15489334
16595799
16595800
17032657
18593712
18995831
19487465
20019387
20131965
20379614
21139048
21890473
21906983
21963094
22570407
22570476
22678362
22987153
23000965
23352259
23503679
24250222
24332808
24778252

Gene Ontology  (GO ID)

Biological Process

GO:0006200  ATP catabolic process
GO:0006284  base-excision repair
GO:0000729  DNA double-strand break processing
GO:0032508  DNA duplex unwinding
GO:0006260  DNA replication
GO:0000076  DNA replication checkpoint
GO:0033567  DNA replication, Okazaki fragment processing
GO:0043137  DNA replication, removal of RNA primer
GO:0006271  DNA strand elongation during DNA replication
GO:0043504  mitochondrial DNA repair
GO:0006264  mitochondrial DNA replication
GO:0000278  mitotic cell cycle
GO:0045740  positive regulation of DNA replication
GO:0000723  telomere maintenance
GO:0000722  telomere maintenance via recombination
GO:0032201  telomere maintenance via semi-conservative replication

Cellular Component

GO:0005760  gamma DNA polymerase complex
GO:0042645  mitochondrial nucleoid
GO:0005654  nucleoplasm
GO:0005634  nucleus

Molecular Function

GO:0051539  4 iron, 4 sulfur cluster binding
GO:0043139  5'-3' DNA helicase activity
GO:0017108  5'-flap endonuclease activity
GO:0005524  ATP binding
GO:0016887  ATPase activity
GO:0003677  DNA binding
GO:0003678  DNA helicase activity
GO:0004386  helicase activity
GO:0046872  metal ion binding
GO:0004518  nuclease activity
GO:0005515  protein binding
GO:0043142  single-stranded DNA-dependent ATPase activity
GO:0016890  site-specific endodeoxyribonuclease activity, specific for altered base