angiotensin II receptor, type 2

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Synonym

MRX88, angiotensin II receptor, type 2, Type-2 angiotensin II receptor, AT2, AGTR2, angiotensin receptor 2, ATGR2

normal 40 tissues
cell lines, primary cells, adult tissues and fetal tissues (FANTOM5 CAGE)

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain

blood

connective

EST

cerebrum:1.20

cerebellum:-

brain stem:-

corpus callosum/glia:-

pineal gland:-

peripheral nerve:-

spine:-

retina:-

eye:-

artery/aorta:-

vein:-

lymphnode:-

peripheral blood:-

spleen:-

thymus:-

bone marrow:-

adipose:-

bone:-

skin:-

GeneChip

cerebrum:4.56

cerebellum:4.59

brain stem:4.64

corpus callosum/glia:4.49

pineal gland:-

peripheral nerve:4.51

spine:4.50

retina:-

eye:-

artery/aorta:4.68

vein:4.72

lymphnode:4.40

peripheral blood:-

spleen:4.29

thymus:4.39

bone marrow:4.58

adipose:4.51

bone:-

skin:4.49

CAGE

cerebrum:0.06

cerebellum:-

brain stem:0

corpus callosum/glia:0

pineal gland:0

peripheral nerve:-

spine:0

retina:-

eye:-

artery/aorta:0

vein:0

lymphnode:0.20

peripheral blood:-

spleen:0

thymus:0.18

bone marrow:-

adipose:0.14

bone:-

skin:-

RNA-seq

cerebrum:0

cerebellum:-

brain stem:-

corpus callosum/glia:-

pineal gland:-

peripheral nerve:-

spine:-

retina:-

eye:-

artery/aorta:-

vein:-

lymphnode:0.11

peripheral blood:-

spleen:-

thymus:-

bone marrow:-

adipose:0

bone:-

skin:-

reproductive

muscular

alimentary

liver

lung

urinary

endo/exo-crine

EST

uterus:9.10

placenta:-

prostate:-

ovary:-

testis:-

heart:51.10

muscle:-

esophagus:-

stomach:-

intestine:-

colon:-

liver/hepato:-

lung:14.70

bladder:-

kidney:31.20

pituitary:-

thyroid/parathyroid:-

adrenal gland:-

pancreas:-

breast:-

salivary:-

GeneChip

uterus:5.15

placenta:4.16

prostate:4.41

ovary:4.67

testis:4.38

heart:4.58

muscle:4.81

esophagus:4.44

stomach:4.54

intestine:4.51

colon:4.67

liver/hepato:4.56

lung:4.73

bladder:-

kidney:4.52

pituitary:4.56

thyroid/parathyroid:4.53

adrenal gland:4.54

pancreas:4.62

breast:4.43

salivary:4.62

CAGE

uterus:1.79

placenta:0

prostate:0

ovary:0.52

testis:0.07

heart:0.27

muscle:0

esophagus:0.09

stomach:-

intestine:0

colon:0

liver/hepato:0

lung:2.77

bladder:0

kidney:0.15

pituitary:0

thyroid/parathyroid:0

adrenal gland:-

pancreas:0.58

breast:0

salivary:0

RNA-seq

uterus:-

placenta:-

prostate:0.15

ovary:0.36

testis:0.20

heart:0.16

muscle:0

esophagus:-

stomach:-

intestine:-

colon:0.12

liver/hepato:0

lung:1.49

bladder:-

kidney:0.05

pituitary:-

thyroid/parathyroid:0.03

adrenal gland:0.06

pancreas:-

breast:0

salivary:-

IDs

Refseq ID	NM_000686
Gene ID	186
Unigene ID	Hs.405348
Probe set ID	222321_at [HG-U133_Plus_2]
Ensembl ID	ENSG00000180772
GTEx ID	ENSG00000180772

Orthologous Gene

Mouse[1]	NM_007429
Rat[1]	NM_007429

Chromosomal Region

Xq23 [115,301,975 - 115,306,225]

Search genes near this gene
- Between -5kb and +5kb
- Between -10kb and +10kb

Gene Family (Interpro ID)

IPR000276	7TM GPCR, rhodopsin-like
IPR000248	Angiotensin II receptor
IPR000147	AT2 angiotensin II receptor
IPR000496	Bradykinin receptor
IPR000355	Chemokine receptor
IPR017452	GPCR, rhodopsin-like superfamily
IPR002286	P2 purinoceptor

Gene Ontology (GO ID)

Biological Process

GO:0007610	behavior
GO:0001974	blood vessel remodeling
GO:0007420	brain development
GO:0002035	brain renin-angiotensin system
GO:0007166	cell surface receptor linked signal transduction
GO:0006883	cellular sodium ion homeostasis
GO:0021695	cerebellar cortex development
GO:0042416	dopamine biosynthetic process
GO:0007186	G-protein coupled receptor protein signaling pathway
GO:0007199	G-protein signaling, coupled to cGMP nucleotide second messenger
GO:0006954	inflammatory response
GO:0043537	negative regulation of blood vessel endothelial cell migration
GO:0030308	negative regulation of cell growth
GO:0048147	negative regulation of fibroblast proliferation
GO:0010459	negative regulation of heart rate
GO:0051387	negative regulation of nerve growth factor receptor signaling pathway
GO:0010700	negative regulation of norepinephrine secretion
GO:0007263	nitric oxide mediated signal transduction
GO:0090190	positive regulation of branching involved in ureteric bud morphogenesis
GO:0008284	positive regulation of cell proliferation
GO:0050715	positive regulation of cytokine secretion
GO:0045429	positive regulation of nitric oxide biosynthetic process
GO:0051000	positive regulation of nitric-oxide synthase activity
GO:0032516	positive regulation of phosphoprotein phosphatase activity
GO:0045893	positive regulation of transcription, DNA-dependent
GO:0045909	positive regulation of vasodilation
GO:0007243	protein kinase cascade
GO:0008217	regulation of blood pressure
GO:0001991	regulation of systemic arterial blood pressure by circulatory renin-angiotensin
GO:0042990	regulation of transcription factor import into nucleus
GO:0002018	renin-angiotensin regulation of aldosterone production
GO:0010243	response to organic nitrogen
GO:0002033	vasodilation by angiotensin involved in regulation of systemic arterial blood pressure

Cellular Component

GO:0005576	extracellular region
GO:0005887	integral to plasma membrane
GO:0048471	perinuclear region of cytoplasm
GO:0005886	plasma membrane

Molecular Function

GO:0004945	angiotensin type II receptor activity
GO:0017046	peptide hormone binding
GO:0005515	protein binding
GO:0048019	receptor antagonist activity
GO:0008134	transcription factor binding

angiotensin II receptor, type 2

Synonym

Expression Pattern

Choropleth map on BodyParts3D

Classification in 40 Organs

Gene Information

IDs

Orthologous Gene

Chromosomal Region

Gene Family (Interpro ID)

Link to Pubmed (Pubmed ID)

Gene Ontology (GO ID)

Biological Process

Cellular Component

Molecular Function