phosphoinositide kinase, FYVE finger containing

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Synonym

PIKfyve, 1-phosphatidylinositol-4-phosphate 5-kinase, PIP5K, CFD, FYVE finger-containing phosphoinositide kinase, MGC40423, Phosphatidylinositol-3-phosphate 5-kinase type III, PIP5K3, PIKFYVE, KIAA0981, p235, PtdIns(4)P-5-kinase

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:36.70 cerebellum:25.20 brain stem:- corpus callosum/glia:29.20 pineal gland:- peripheral nerve:- spine:- retina:- eye:35.30 artery/aorta:- vein:- lymphnode:91 peripheral blood:36.40 spleen:18.90 thymus:51.50 bone marrow:78.70 adipose:- bone:38.40 skin:62.40
GeneChip nodata
CAGE cerebrum:4.20 cerebellum:- brain stem:3.88 corpus callosum/glia:3.92 pineal gland:4.90 peripheral nerve:- spine:4.60 retina:- eye:- artery/aorta:3.95 vein:4.17 lymphnode:4.12 peripheral blood:- spleen:4.07 thymus:4.20 bone marrow:- adipose:3.94 bone:- skin:-
RNA-seq cerebrum:0.59 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:0.09 peripheral blood:- spleen:- thymus:- bone marrow:- adipose:0.05 bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:18.20 placenta:47.40 prostate:11.30 ovary:37.30 testis:56.20 heart:- muscle:- esophagus:- stomach:21.20 intestine:64.80 colon:33.90     liver/hepato:137.20        lung:29.30    bladder:- kidney:- pituitary:- thyroid/parathyroid:- adrenal gland:- pancreas:35.60 breast:37.20 salivary:-
GeneChip nodata
CAGE uterus:3.94 placenta:3.38 prostate:3.87 ovary:3.53 testis:3.66 heart:4.04 muscle:3.55 esophagus:3.41 stomach:- intestine:3.70 colon:3.81     liver/hepato:3.49    lung:4.08 bladder:3.77 kidney:3.70 pituitary:4.23 thyroid/parathyroid:3.27 adrenal gland:- pancreas:3.26 breast:4.48 salivary:3.52
RNA-seq uterus:- placenta:- prostate:0.13 ovary:0.11 testis:0.31 heart:0.12 muscle:0.00 esophagus:- stomach:- intestine:- colon:0.08     liver/hepato:0.20        lung:0.24    bladder:- kidney:0.09 pituitary:- thyroid/parathyroid:0.69 adrenal gland:0.46 pancreas:- breast:0.46 salivary:-

Gene Information

IDs

Refseq ID NM_152671
Gene ID 200576
Unigene ID Hs.173939
Probe set ID -
Ensembl ID ENSG00000115020
GTEx ID ENSG00000115020

Orthologous Gene

Mouse[1]  NM_011086
Rat[1]  NM_011086

Chromosomal Region

2q34  [209,130,991  -  209,223,475]

Gene Family (Interpro ID)

IPR000591  DEP domain
IPR002498  Phosphatidylinositol-4-phosphate 5-kinase, core
IPR016034  Phosphatidylinositol-4-phosphate 5-kinase, core, subgroup
IPR011991  Winged helix repressor DNA-binding
IPR000306  Zinc finger, FYVE-type
IPR011011  Zinc finger, FYVE/PHD-type
IPR013083  Zinc finger, RING/FYVE/PHD-type

Link to Pubmed  (Pubmed ID)

10231032
11706043
11714711
12270933
12477932
12607114
14530284
14551253
14702039
15046600
15144186
15542851
15592455
15902656
16147992
16448788
16801682
16954148
17081983
17146146
17207965
17556371
17570343
17909029
18304842
18429927
18501703
18774718
18950639
19037259
19056739
19232516
19582903
19840946
19841139
19852935
19910676
20041238
20193073
20379614
20467438
20945365
21832049
22065932
22118674
22621786
23154468
23178941
23188060
23297396
23757022
23994136
24250222
24600036
24816145

Gene Ontology  (GO ID)

Biological Process

GO:0044267  cellular protein metabolic process
GO:0032288  myelin assembly
GO:0006661  phosphatidylinositol biosynthetic process
GO:0006644  phospholipid metabolic process
GO:0034504  protein localization in nucleus
GO:0006898  receptor-mediated endocytosis
GO:0042147  retrograde transport, endosome to Golgi

Cellular Component

GO:0031410  cytoplasmic vesicle
GO:0005829  cytosol
GO:0031901  early endosome membrane
GO:0010008  endosome membrane
GO:0000139  Golgi membrane
GO:0031902  late endosome membrane
GO:0045121  membrane raft
GO:0048471  perinuclear region of cytoplasm

Molecular Function

GO:0000285  1-phosphatidylinositol-3-phosphate 5-kinase activity
GO:0016308  1-phosphatidylinositol-4-phosphate 5-kinase activity
GO:0005524  ATP binding
GO:0046872  metal ion binding
GO:0043813  phosphatidylinositol-3,5-bisphosphate 5-phosphatase activity
GO:0005515  protein binding