MAP/microtubule affinity-regulating kinase 2

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Synonym

EMK1, PAR1 homolog, PAR-1, ELKL motif kinase, Serine/threonine-protein kinase MARK2, MGC99619, MARK2, MAP/microtubule affinity-regulating kinase 2

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:43.90 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:30.70 spine:- retina:- eye:47 artery/aorta:- vein:66.60 lymphnode:30.30 peripheral blood:18.20 spleen:75.60 thymus:25.80 bone marrow:78.70 adipose:40.30 bone:64 skin:100.80
GeneChip cerebrum:6.21 cerebellum:5.99 brain stem:5.92 corpus callosum/glia:6.26 pineal gland:- peripheral nerve:5.98 spine:5.91 retina:- eye:- artery/aorta:6.05 vein:6.03 lymphnode:6.43 peripheral blood:- spleen:6.35 thymus:6.02 bone marrow:6.25 adipose:6 bone:- skin:6.24
CAGE cerebrum:3.70 cerebellum:- brain stem:3.72 corpus callosum/glia:3.91 pineal gland:3.36 peripheral nerve:- spine:3.42 retina:- eye:- artery/aorta:2.99 vein:3.33 lymphnode:3.56 peripheral blood:- spleen:3.71 thymus:3.83 bone marrow:- adipose:3.05 bone:- skin:-
RNA-seq cerebrum:0.39 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:2.27 peripheral blood:- spleen:- thymus:- bone marrow:- adipose:0.00 bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:27.30 placenta:91.10 prostate:67.60 ovary:37.30 testis:26 heart:- muscle:- esophagus:- stomach:- intestine:32.40 colon:169.60     liver/hepato:21.10        lung:39.10    bladder:125.60 kidney:- pituitary:- thyroid/parathyroid:- adrenal gland:- pancreas:80 breast:74.30 salivary:-
GeneChip uterus:5.88 placenta:5.99 prostate:6.23 ovary:5.85 testis:6.08 heart:6.06 muscle:5.72 esophagus:7.01 stomach:6.09 intestine:5.82 colon:6.48 liver/hepato:5.77 lung:6.11 bladder:- kidney:6.06 pituitary:6.28 thyroid/parathyroid:6.20 adrenal gland:5.88 pancreas:5.71 breast:6.30 salivary:6.48
CAGE uterus:3.30 placenta:3.81 prostate:3.40 ovary:3.09 testis:3.22 heart:3.14 muscle:2.97 esophagus:3.69 stomach:- intestine:4.14 colon:3.83     liver/hepato:2.78    lung:3.29 bladder:3.06 kidney:3.33 pituitary:3.76 thyroid/parathyroid:3.26 adrenal gland:- pancreas:3.29 breast:2.95 salivary:3.91
RNA-seq uterus:- placenta:- prostate:0.40 ovary:0.47 testis:0.90 heart:0.00 muscle:0.00 esophagus:- stomach:- intestine:- colon:1.57     liver/hepato:0.05        lung:0.95    bladder:- kidney:0.21 pituitary:- thyroid/parathyroid:0.00 adrenal gland:0.00 pancreas:- breast:0.00 salivary:-

Gene Information

IDs

Refseq ID NM_001163297
Gene ID 2011
Unigene ID Hs.567261
Probe set ID 203942_s_at  [HG-U133_Plus_2]
Ensembl ID ENSG00000072518
GTEx ID ENSG00000072518

Orthologous Gene

Mouse[10]  NM_001080388, NM_001080389, NM_001080390, NM_007928
Rat [0]  

Chromosomal Region

11q13.1  [63,606,400  -  63,678,491]

Gene Family (Interpro ID)

IPR000719  Protein kinase, catalytic domain
IPR011009  Protein kinase-like domain
IPR002290  Serine/threonine-protein kinase domain
IPR017442  Serine/threonine-protein kinase-like domain
IPR001245  Tyrosine-protein kinase, catalytic domain
IPR020635  Tyrosine-protein kinase, subgroup, catalytic domain
IPR000449  Ubiquitin-associated/translation elongation factor EF1B, N-terminal
IPR015940  Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote

Link to Pubmed  (Pubmed ID)

7613050
8125298
8274451
8889548
8938448
9108484
9730619
10516437
11257119
11433294
12429843
12477932
14676191
14743216
14976552
15158914
15161933
15302935
15324659
15365179
15489334
15492257
15778465
16257959
16306228
16344560
16396636
16472737
16551573
16554811
16707567
16775013
16803889
16964243
16968750
16980613
17081983
17192257
17234589
17353931
17442826
17979178
18005242
18045904
18292230
18315603
18760999
19011111
19530321
19553522
19615732
19945424
19953087
20194617
20360068
20508642
21130132
21139048
21513698
21890473
22072711
22238344
22298430
22848487
22883624
23000965
23383273
24165937
24251416
24255178
24259665
24354359
24816145

Gene Ontology  (GO ID)

Biological Process

GO:0030010  establishment of cell polarity
GO:0045197  establishment or maintenance of epithelial cell apical/basal polarity
GO:0001764  neuron migration
GO:0010976  positive regulation of neuron projection development
GO:0046777  protein amino acid autophosphorylation
GO:0006468  protein amino acid phosphorylation
GO:0007243  protein kinase cascade
GO:0050770  regulation of axonogenesis
GO:0051493  regulation of cytoskeleton organization
GO:0016055  Wnt receptor signaling pathway

Cellular Component

GO:0045180  basal cortex
GO:0016020  membrane
GO:0005634  nucleus
GO:0005886  plasma membrane

Molecular Function

GO:0005524  ATP binding
GO:0008289  lipid binding
GO:0000287  magnesium ion binding
GO:0005515  protein binding
GO:0004674  protein serine/threonine kinase activity
GO:0050321  tau-protein kinase activity