homeodomain interacting protein kinase 1

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Synonym

HIPK1, MGC33548, MGC33446, KIAA0630, Myak, Nbak2, homeodomain interacting protein kinase 1, MGC26642, Homeodomain-interacting protein kinase 1

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:59.30 cerebellum:63 brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:61.30 spine:224.60 retina:118.60 eye:88.20 artery/aorta:30 vein:- lymphnode:70.80 peripheral blood:18.20 spleen:18.90 thymus:116 bone marrow:157.40 adipose:40.30 bone:38.40 skin:24
GeneChip cerebrum:7.33 cerebellum:8.60 brain stem:7.31 corpus callosum/glia:7.70 pineal gland:- peripheral nerve:7 spine:8.07 retina:- eye:- artery/aorta:7.17 vein:7.46 lymphnode:7.50 peripheral blood:- spleen:7.74 thymus:9.36 bone marrow:8.30 adipose:7.41 bone:- skin:7.55
CAGE cerebrum:4.06 cerebellum:- brain stem:3.80 corpus callosum/glia:4.20 pineal gland:3.98 peripheral nerve:- spine:4.05 retina:- eye:- artery/aorta:3.82 vein:3.79 lymphnode:3.43 peripheral blood:- spleen:3.83 thymus:4.79 bone marrow:- adipose:3.76 bone:- skin:-
RNA-seq cerebrum:0.00 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:1.20 peripheral blood:- spleen:- thymus:- bone marrow:- adipose:1.23 bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:45.60 placenta:32.80 prostate:56.30 ovary:- testis:164.40 heart:25.50 muscle:40.20 esophagus:- stomach:42.50 intestine:- colon:67.80     liver/hepato:84.40        lung:73.30    bladder:- kidney:62.40 pituitary:347.90 thyroid/parathyroid:327.50 adrenal gland:50.80 pancreas:151.10 breast:204.40 salivary:-
GeneChip uterus:7.68 placenta:7.41 prostate:7.87 ovary:8.41 testis:8.16 heart:7.28 muscle:7.54 esophagus:7.50 stomach:7.31 intestine:7.54 colon:7.12 liver/hepato:6.84 lung:7.83 bladder:- kidney:7.24 pituitary:7.74 thyroid/parathyroid:8.11 adrenal gland:7.70 pancreas:6.93 breast:7.54 salivary:6.87
CAGE uterus:3.97 placenta:3.70 prostate:3.87 ovary:3.90 testis:4.51 heart:4.00 muscle:3.77 esophagus:3.85 stomach:- intestine:3.49 colon:3.68     liver/hepato:3.34    lung:3.93 bladder:4.01 kidney:3.63 pituitary:4.25 thyroid/parathyroid:3.92 adrenal gland:- pancreas:3.40 breast:3.33 salivary:3.57
RNA-seq uterus:- placenta:- prostate:0.00 ovary:0.98 testis:0.60 heart:0.00 muscle:0.56 esophagus:- stomach:- intestine:- colon:1.00     liver/hepato:0.12        lung:1.09    bladder:- kidney:0.44 pituitary:- thyroid/parathyroid:1.37 adrenal gland:0.14 pancreas:- breast:0.00 salivary:-

Gene Information

IDs

Refseq ID NM_198269
Gene ID 204851
Unigene ID Hs.532363
Probe set ID 212293_at  [HG-U133_Plus_2]
Ensembl ID ENSG00000163349
GTEx ID ENSG00000163349

Orthologous Gene

Mouse[8]  NM_010432
Rat[1]  NM_001100986

Chromosomal Region

1p13.2  [114,471,814  -  114,520,426]

Gene Family (Interpro ID)

IPR000719  Protein kinase, catalytic domain
IPR011009  Protein kinase-like domain
IPR002290  Serine/threonine-protein kinase domain
IPR017442  Serine/threonine-protein kinase-like domain
IPR001245  Tyrosine-protein kinase, catalytic domain
IPR020635  Tyrosine-protein kinase, subgroup, catalytic domain

Link to Pubmed  (Pubmed ID)

9734811
9748262
12477932
12529400
12702766
12968034
14702039
15231748
15489334
15701637
16390825
16917507
18029348
19250734
19646965
20936779
21890473
21906983
21963094
22173032
22645275
23071292
23535729
23565059
23602568
23676219
24559171

Gene Ontology  (GO ID)

Biological Process

GO:0009952  anterior/posterior pattern formation
GO:0060216  definitive hemopoiesis
GO:0042771  DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis
GO:0048596  embryonic camera-type eye morphogenesis
GO:0060059  embryonic retina morphogenesis in camera-type eye
GO:0001654  eye development
GO:0060235  lens induction in camera-type eye
GO:0030182  neuron differentiation
GO:0045766  positive regulation of angiogenesis
GO:0008284  positive regulation of cell proliferation
GO:0016926  protein desumoylation
GO:0006355  regulation of transcription, DNA-dependent
GO:0010803  regulation of tumor necrosis factor-mediated signaling pathway
GO:0010842  retina layer formation
GO:0007224  smoothened signaling pathway
GO:0006351  transcription, DNA-dependent

Cellular Component

GO:0005737  cytoplasm
GO:0016607  nuclear speck
GO:0005634  nucleus
GO:0016605  PML body

Molecular Function

GO:0005524  ATP binding
GO:0042802  identical protein binding
GO:0005515  protein binding
GO:0004674  protein serine/threonine kinase activity