aldehyde dehydrogenase 1 family, member A3

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Synonym

RALDH-3, aldehyde dehydrogenase 1 family, member A3, RALDH3, ALDH6, Aldehyde dehydrogenase 6, Aldehyde dehydrogenase 1A3, ALDH1A3, ALDH1A6, Retinaldehyde dehydrogenase 3

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:23.70 cerebellum:75.60 brain stem:- corpus callosum/glia:145.80 pineal gland:- peripheral nerve:30.70 spine:112.30 retina:118.60 eye:41.10 artery/aorta:89.90 vein:- lymphnode:91 peripheral blood:- spleen:37.80 thymus:- bone marrow:- adipose:161.30 bone:38.40 skin:67.20
GeneChip cerebrum:5.11 cerebellum:5.52 brain stem:5.14 corpus callosum/glia:4.90 pineal gland:- peripheral nerve:7.49 spine:5.26 retina:- eye:- artery/aorta:5.74 vein:6.38 lymphnode:5.73 peripheral blood:- spleen:4.93 thymus:4.27 bone marrow:5.69 adipose:6.67 bone:- skin:5.76
CAGE cerebrum:1.26 cerebellum:- brain stem:1.27 corpus callosum/glia:1.36 pineal gland:2.65 peripheral nerve:- spine:1.82 retina:- eye:- artery/aorta:2.51 vein:2.03 lymphnode:2.94 peripheral blood:- spleen:1.15 thymus:0.71 bone marrow:- adipose:2.72 bone:- skin:-
RNA-seq cerebrum:2.30 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:2.89 peripheral blood:- spleen:- thymus:- bone marrow:- adipose:3.21 bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:91.10 placenta:21.90 prostate:337.90 ovary:- testis:82.20 heart:12.80 muscle:20.10 esophagus:- stomach:- intestine:32.40 colon:135.70     liver/hepato:-        lung:190.60    bladder:- kidney:- pituitary:- thyroid/parathyroid:163.70 adrenal gland:- pancreas:- breast:334.50 salivary:-
GeneChip uterus:6.31 placenta:5.84 prostate:9.83 ovary:6.23 testis:6.39 heart:6.10 muscle:5.63 esophagus:7.41 stomach:6.77 intestine:7.06 colon:5.99 liver/hepato:4.98 lung:5.72 bladder:- kidney:5.38 pituitary:5.39 thyroid/parathyroid:4.61 adrenal gland:6.04 pancreas:5.50 breast:7.15 salivary:7.58
CAGE uterus:2.71 placenta:2.21 prostate:4.45 ovary:2.80 testis:3.57 heart:2.14 muscle:1.76 esophagus:2.84 stomach:- intestine:3.29 colon:2.91     liver/hepato:0.90    lung:2.27 bladder:3.10 kidney:1.97 pituitary:3.19 thyroid/parathyroid:0.90 adrenal gland:- pancreas:2.48 breast:2.79 salivary:3.97
RNA-seq uterus:- placenta:- prostate:4.18 ovary:3.12 testis:5.39 heart:1.37 muscle:1.98 esophagus:- stomach:- intestine:- colon:3.89     liver/hepato:1.07        lung:3.79    bladder:- kidney:3.06 pituitary:- thyroid/parathyroid:1.54 adrenal gland:4.37 pancreas:- breast:3.85 salivary:-

Gene Information

IDs

Refseq ID NM_000693
Gene ID 220
Unigene ID Hs.459538
Probe set ID 203180_at  [HG-U133_Plus_2]
Ensembl ID ENSG00000184254
GTEx ID ENSG00000184254

Orthologous Gene

Mouse[3]  NM_053080
Rat[1]  NM_153300

Chromosomal Region

15q26.3  [101,419,581  -  101,456,831]

Gene Family (Interpro ID)

-

Link to Pubmed  (Pubmed ID)

7698756
9490025
11585737
12040753
12477932
14702039
15245423
15489334
19322201
19343046
19478994
19703508
20709019
20833146
20967262
21280157
21906983
21963094
22131125
22960273
23250514
23312594
23436614
23591992
23646827
23650391
23881059
24024553
24047698
24053169
24167362
24568872
24777706
24907115

Gene Ontology  (GO ID)

Biological Process

GO:0048048  embryonic eye morphogenesis
GO:0060324  face development
GO:0021768  nucleus accumbens development
GO:0060166  olfactory pit development
GO:0002072  optic cup morphogenesis involved in camera-type eye development
GO:0043065  positive regulation of apoptosis
GO:0042574  retinal metabolic process
GO:0002138  retinoic acid biosynthetic process
GO:0042573  retinoic acid metabolic process
GO:0042572  retinol metabolic process

Cellular Component

GO:0005737  cytoplasm

Molecular Function

GO:0004029  aldehyde dehydrogenase (NAD) activity
GO:0004030  aldehyde dehydrogenase [NAD(P)+] activity
GO:0070403  NAD binding
GO:0042803  protein homodimerization activity
GO:0070324  thyroid hormone binding