AP2 associated kinase 1

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Synonym

Adaptor-associated kinase 1, AP2 associated kinase 1, KIAA1048, AAK1, AP2-associated protein kinase 1, MGC138170

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:107.80 cerebellum:88.20 brain stem:- corpus callosum/glia:- pineal gland:741.70 peripheral nerve:30.70 spine:- retina:237.30 eye:105.80 artery/aorta:30 vein:66.60 lymphnode:60.70 peripheral blood:18.20 spleen:75.60 thymus:128.80 bone marrow:98.40 adipose:- bone:51.20 skin:120
GeneChip cerebrum:9.29 cerebellum:9.27 brain stem:9.02 corpus callosum/glia:8.50 pineal gland:- peripheral nerve:9.10 spine:8.81 retina:- eye:- artery/aorta:8.73 vein:8.43 lymphnode:9.42 peripheral blood:- spleen:9.54 thymus:9.33 bone marrow:8.60 adipose:8.32 bone:- skin:8
CAGE cerebrum:4.03 cerebellum:- brain stem:3.64 corpus callosum/glia:3.10 pineal gland:4.86 peripheral nerve:- spine:3.74 retina:- eye:- artery/aorta:3.61 vein:3.31 lymphnode:3.20 peripheral blood:- spleen:2.58 thymus:3.05 bone marrow:- adipose:2.60 bone:- skin:-
RNA-seq cerebrum:3.29 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:2.17 peripheral blood:- spleen:- thymus:- bone marrow:- adipose:2.10 bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:100.20 placenta:87.40 prostate:90.10 ovary:74.50 testis:38.90 heart:51.10 muscle:20.10 esophagus:- stomach:42.50 intestine:64.80 colon:127.20     liver/hepato:63.30        lung:19.60    bladder:- kidney:20.80 pituitary:232 thyroid/parathyroid:327.50 adrenal gland:50.80 pancreas:106.70 breast:65.10 salivary:-
GeneChip uterus:8.39 placenta:9.44 prostate:8.63 ovary:8.30 testis:7.88 heart:8.72 muscle:7.20 esophagus:8.50 stomach:8.92 intestine:8 colon:8.66 liver/hepato:8.31 lung:9 bladder:- kidney:9.33 pituitary:9.25 thyroid/parathyroid:10.21 adrenal gland:9.52 pancreas:7.68 breast:8.75 salivary:7.73
CAGE uterus:2.73 placenta:3.33 prostate:2.35 ovary:2.56 testis:2.55 heart:3.38 muscle:2.64 esophagus:2.59 stomach:- intestine:2.89 colon:3.04     liver/hepato:1.84    lung:3.24 bladder:2.54 kidney:3.06 pituitary:3.68 thyroid/parathyroid:3.14 adrenal gland:- pancreas:2.94 breast:3.60 salivary:2.35
RNA-seq uterus:- placenta:- prostate:1.79 ovary:2.15 testis:1.93 heart:2.92 muscle:1.50 esophagus:- stomach:- intestine:- colon:1.60     liver/hepato:0.88        lung:1.64    bladder:- kidney:2.46 pituitary:- thyroid/parathyroid:2.52 adrenal gland:1.95 pancreas:- breast:1.91 salivary:-

Gene Information

IDs

Refseq ID NM_014911
Gene ID 22848
Unigene ID Hs.468878
Probe set ID 205434_s_at  [HG-U133_Plus_2]
Ensembl ID ENSG00000115977
GTEx ID ENSG00000115977

Orthologous Gene

Mouse[2]  NM_001040106, NM_177762
Rat [0]  

Chromosomal Region

2p13.3  [69,688,532  -  69,901,481]

Gene Family (Interpro ID)

IPR000719  Protein kinase, catalytic domain
IPR011009  Protein kinase-like domain
IPR002290  Serine/threonine-protein kinase domain
IPR017442  Serine/threonine-protein kinase-like domain
IPR001245  Tyrosine-protein kinase, catalytic domain
IPR020635  Tyrosine-protein kinase, subgroup, catalytic domain

Link to Pubmed  (Pubmed ID)

10470851
11877457
11877461
12471243
12477932
12952931
14617351
14702039
15292237
15302935
15489334
15815621
16083285
16344560
16782842
16903783
16964243
17178891
17494869
18029348
18657069
18976975
19380743
19772629
20379614
21464124
21832049
22645275
23934736

Gene Ontology  (GO ID)

Biological Process

GO:0006897  endocytosis
GO:0045747  positive regulation of Notch signaling pathway
GO:0046777  protein amino acid autophosphorylation
GO:0006468  protein amino acid phosphorylation
GO:0050821  protein stabilization
GO:0032880  regulation of protein localization

Cellular Component

GO:0031252  cell leading edge
GO:0030136  clathrin-coated vesicle
GO:0005905  coated pit
GO:0019897  extrinsic to plasma membrane
GO:0043195  terminal button

Molecular Function

GO:0005524  ATP binding
GO:0005112  Notch binding
GO:0005515  protein binding
GO:0004674  protein serine/threonine kinase activity