DENN/MADD domain containing 3

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Synonym

DENND3, DENN/MADD domain containing 3, KIAA0870

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:- cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:- peripheral blood:- spleen:- thymus:- bone marrow:- adipose:- bone:- skin:-
GeneChip cerebrum:6.08 cerebellum:5.83 brain stem:6.09 corpus callosum/glia:6.29 pineal gland:- peripheral nerve:5.99 spine:6.11 retina:- eye:- artery/aorta:6.28 vein:6.23 lymphnode:7.08 peripheral blood:- spleen:6.97 thymus:5.74 bone marrow:7.43 adipose:6.38 bone:- skin:5.77
CAGE cerebrum:3.18 cerebellum:- brain stem:3.37 corpus callosum/glia:3.27 pineal gland:2.52 peripheral nerve:- spine:3.93 retina:- eye:- artery/aorta:3.68 vein:3.29 lymphnode:3.81 peripheral blood:- spleen:3.45 thymus:2.09 bone marrow:- adipose:3.56 bone:- skin:-
RNA-seq cerebrum:2.39 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:3.04 peripheral blood:- spleen:- thymus:- bone marrow:- adipose:3.42 bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:- placenta:- prostate:- ovary:- testis:- heart:- muscle:- esophagus:- stomach:- intestine:- colon:-     liver/hepato:-        lung:-    bladder:- kidney:- pituitary:- thyroid/parathyroid:- adrenal gland:- pancreas:- breast:- salivary:-
GeneChip uterus:5.81 placenta:5.90 prostate:5.84 ovary:5.82 testis:5.38 heart:6.21 muscle:5.54 esophagus:5.50 stomach:6.24 intestine:5.87 colon:6.25 liver/hepato:5.49 lung:7.81 bladder:- kidney:5.88 pituitary:5.57 thyroid/parathyroid:6.28 adrenal gland:6.06 pancreas:5.83 breast:5.80 salivary:6.44
CAGE uterus:3.06 placenta:2.41 prostate:2.61 ovary:2.51 testis:2.62 heart:2.85 muscle:2.78 esophagus:2.54 stomach:- intestine:2.17 colon:3.32     liver/hepato:1.88    lung:4.21 bladder:3.05 kidney:2.76 pituitary:2.27 thyroid/parathyroid:2.56 adrenal gland:- pancreas:1.59 breast:3.62 salivary:2.66
RNA-seq uterus:- placenta:- prostate:2.19 ovary:1.26 testis:1.44 heart:1.95 muscle:1.11 esophagus:- stomach:- intestine:- colon:2.16     liver/hepato:0.81        lung:3.55    bladder:- kidney:2.54 pituitary:- thyroid/parathyroid:2.07 adrenal gland:3.40 pancreas:- breast:1.79 salivary:-

Gene Information

IDs

Refseq ID NM_014957
Gene ID 22898
Unigene ID Hs.18166
Probe set ID 212975_at  [HG-U133_Plus_2]
Ensembl ID ENSG00000105339
GTEx ID ENSG00000105339

Orthologous Gene

Mouse[1]  NM_001081066
Rat[1]  NM_001081066

Chromosomal Region

8q24.3  [142,127,377  -  142,205,907]

Gene Family (Interpro ID)

IPR001680  WD40 repeat
IPR011046  WD40 repeat-like-containing domain
IPR017986  WD40-repeat-containing domain
IPR015943  WD40/YVTN repeat-like-containing domain

Link to Pubmed  (Pubmed ID)

10048485
10737800
11278422
12477932
14702039
20379614
21502966
21890473
21906983
23251661
24250222

Gene Ontology  (GO ID)

Biological Process

GO:0044257  cellular protein catabolic process
GO:0008333  endosome to lysosome transport

Molecular Function

GO:0017112  Rab guanyl-nucleotide exchange factor activity