Rho guanine nucleotide exchange factor (GEF) 12

Synonym

KIAA0382, Rho guanine nucleotide exchange factor (GEF) 12, LARG, PRO2792, DKFZp686O2372, ARHGEF12, Leukemia-associated RhoGEF, Rho guanine nucleotide exchange factor 12

normal 40 tissues
cell lines, primary cells, adult tissues and fetal tissues (FANTOM5 CAGE)

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain

blood

connective

EST

cerebrum:93.60

cerebellum:12.60

brain stem:-

corpus callosum/glia:29.20

pineal gland:148.30

peripheral nerve:122.70

spine:-

retina:118.60

eye:164.60

artery/aorta:239.80

vein:-

lymphnode:40.40

peripheral blood:-

spleen:113.40

thymus:-

bone marrow:39.40

adipose:121

bone:12.80

skin:158.40

GeneChip

cerebrum:7.97

cerebellum:8.16

brain stem:7.81

corpus callosum/glia:7.06

pineal gland:-

peripheral nerve:7.78

spine:7.67

retina:-

eye:-

artery/aorta:7.96

vein:7.83

lymphnode:7.28

peripheral blood:-

spleen:7.52

thymus:6.68

bone marrow:7.27

adipose:7.76

bone:-

skin:8.31

CAGE

cerebrum:4.34

cerebellum:-

brain stem:3.83

corpus callosum/glia:3.77

pineal gland:4.30

peripheral nerve:-

spine:3.81

retina:-

eye:-

artery/aorta:4.04

vein:3.29

lymphnode:3.32

peripheral blood:-

spleen:3.54

thymus:2.32

bone marrow:-

adipose:3.76

bone:-

skin:-

RNA-seq

cerebrum:4.26

cerebellum:-

brain stem:-

corpus callosum/glia:-

pineal gland:-

peripheral nerve:-

spine:-

retina:-

eye:-

artery/aorta:-

vein:-

lymphnode:0.00

peripheral blood:-

spleen:-

thymus:-

bone marrow:-

adipose:2.58

bone:-

skin:-

reproductive

muscular

alimentary

liver

lung

urinary

endo/exo-crine

EST

uterus:145.80

placenta:138.40

prostate:123.90

ovary:-

testis:21.60

heart:102.20

muscle:120.50

esophagus:-

stomach:169.90

intestine:129.60

colon:780.10

liver/hepato:168.90

lung:68.40

bladder:-

kidney:93.60

pituitary:-

thyroid/parathyroid:-

adrenal gland:101.60

pancreas:71.10

breast:158

salivary:-

GeneChip

uterus:8.13

placenta:8.21

prostate:8.56

ovary:8

testis:6.35

heart:8.06

muscle:7.95

esophagus:7.85

stomach:7.86

intestine:7.90

colon:7.24

liver/hepato:8.52

lung:8.20

bladder:-

kidney:8.67

pituitary:7.93

thyroid/parathyroid:8.59

adrenal gland:8.40

pancreas:6.46

breast:8.06

salivary:7.80

CAGE

uterus:3.91

placenta:3.90

prostate:3.98

ovary:3.95

testis:3.32

heart:4.19

muscle:4.03

esophagus:3.75

stomach:-

intestine:3.80

colon:3.75

liver/hepato:4.26

lung:4.14

bladder:3.79

kidney:4.30

pituitary:3.71

thyroid/parathyroid:3.99

adrenal gland:-

pancreas:3.63

breast:3.80

salivary:3.38

RNA-seq

uterus:-

placenta:-

prostate:2.09

ovary:2.78

testis:2.41

heart:3.95

muscle:4.10

esophagus:-

stomach:-

intestine:-

colon:2.34

liver/hepato:2.76

lung:2.62

bladder:-

kidney:1.72

pituitary:-

thyroid/parathyroid:3.38

adrenal gland:1.62

pancreas:-

breast:1.42

salivary:-

IDs

Refseq ID	NM_015313
Gene ID	23365
Unigene ID	Hs.24598
Probe set ID	201334_s_at [HG-U133_Plus_2]
Ensembl ID	ENSG00000196914
GTEx ID	ENSG00000196914

Orthologous Gene

Mouse[3]	NM_027144
Rat[1]	NM_001013246

Chromosomal Region

11q23.3 [120,207,787 - 120,360,645]

Search genes near this gene
- Between -5kb and +5kb
- Between -10kb and +10kb

Gene Family (Interpro ID)

IPR001849

Pleckstrin homology

GO:0007411	axon guidance
GO:0007186	G-protein coupled receptor protein signaling pathway
GO:0048011	nerve growth factor receptor signaling pathway
GO:0043065	positive regulation of apoptosis
GO:0035023	regulation of Rho protein signal transduction
GO:0051056	regulation of small GTPase mediated signal transduction
GO:0007264	small GTPase mediated signal transduction

GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0016020	membrane

GO:0001664	G-protein-coupled receptor binding
GO:0005096	GTPase activator activity
GO:0005543	phospholipid binding
GO:0005515	protein binding
GO:0005089	Rho guanyl-nucleotide exchange factor activity

Rho guanine nucleotide exchange factor (GEF) 12

Synonym

Expression Pattern

Choropleth map on BodyParts3D

Classification in 40 Organs

Gene Information

IDs

Orthologous Gene

Chromosomal Region

Gene Family (Interpro ID)

Link to Pubmed (Pubmed ID)

Gene Ontology (GO ID)

Biological Process

Cellular Component

Molecular Function