tensin like C1 domain containing phosphatase (tensin 2)

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Synonym

DKFZp686D13244, C1TEN, C1-TEN, tensin like C1 domain-containing phosphatase, KIAA1075, TENC1, FLJ16320, TNS2

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:293.90 cerebellum:239.30 brain stem:- corpus callosum/glia:408.30 pineal gland:- peripheral nerve:- spine:112.30 retina:- eye:141 artery/aorta:299.80 vein:66.60 lymphnode:10.10 peripheral blood:72.90 spleen:189.10 thymus:103.10 bone marrow:- adipose:40.30 bone:153.50 skin:72
GeneChip cerebrum:7.26 cerebellum:6.86 brain stem:7.33 corpus callosum/glia:7.75 pineal gland:- peripheral nerve:7.64 spine:7.32 retina:- eye:- artery/aorta:8.45 vein:8.06 lymphnode:7.10 peripheral blood:- spleen:7.97 thymus:6.19 bone marrow:6.20 adipose:8.47 bone:- skin:7.36
CAGE cerebrum:2.92 cerebellum:- brain stem:3.23 corpus callosum/glia:3.28 pineal gland:3.18 peripheral nerve:- spine:3.13 retina:- eye:- artery/aorta:3.95 vein:4.30 lymphnode:3.25 peripheral blood:- spleen:4.18 thymus:0.99 bone marrow:- adipose:5.16 bone:- skin:-
RNA-seq cerebrum:2.84 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:4.38 peripheral blood:- spleen:- thymus:- bone marrow:- adipose:5.46 bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:109.40 placenta:18.20 prostate:191.50 ovary:74.50 testis:21.60 heart:63.90 muscle:60.30 esophagus:- stomach:63.70 intestine:324 colon:59.40     liver/hepato:10.60        lung:92.90    bladder:251.20 kidney:83.20 pituitary:- thyroid/parathyroid:163.70 adrenal gland:50.80 pancreas:26.70 breast:74.30 salivary:-
GeneChip uterus:7.77 placenta:6.85 prostate:7.22 ovary:7.75 testis:6.63 heart:7.92 muscle:6.87 esophagus:7.23 stomach:7.61 intestine:7.18 colon:7.48 liver/hepato:8.02 lung:8.34 bladder:- kidney:7.62 pituitary:7.30 thyroid/parathyroid:7.66 adrenal gland:8.40 pancreas:6.68 breast:8.08 salivary:7.07
CAGE uterus:4.44 placenta:3.45 prostate:3.97 ovary:4.09 testis:3.26 heart:4.33 muscle:4.53 esophagus:3.77 stomach:- intestine:3.23 colon:3.66     liver/hepato:3.67    lung:4.25 bladder:3.87 kidney:3.91 pituitary:3.28 thyroid/parathyroid:3.73 adrenal gland:- pancreas:3.13 breast:4.64 salivary:3.15
RNA-seq uterus:- placenta:- prostate:4.72 ovary:4.90 testis:4.53 heart:3.50 muscle:3.97 esophagus:- stomach:- intestine:- colon:4.86     liver/hepato:3.29        lung:4.24    bladder:- kidney:4.14 pituitary:- thyroid/parathyroid:4.41 adrenal gland:4.77 pancreas:- breast:4.68 salivary:-

Gene Information

IDs

Refseq ID NM_198316
Gene ID 23371
Unigene ID Hs.343334
Probe set ID 212494_at  [HG-U133_Plus_2]
Ensembl ID ENSG00000111077
GTEx ID ENSG00000111077

Orthologous Gene

Mouse[1]  NM_153533
Rat[1]  NM_153533

Chromosomal Region

12q13.13  [53,440,753  -  53,458,156]

Gene Family (Interpro ID)

IPR008973  C2 calcium/lipid-binding domain, CaLB
IPR006020  Phosphotyrosine interaction domain
IPR011993  Pleckstrin homology-type
IPR014020  Tensin phosphatase, C2 domain

Link to Pubmed  (Pubmed ID)

10470851
11792844
12470648
12477932
12606711
15117958
15817639
16273093
16713569
16951145
17006924
17190795
19194507
19440389
19747564
19895840
20069572
20678486
21139048
21461930
21527831
21743057
21765928
21988832
22019427
22645138
23233134
23455922

Gene Ontology  (GO ID)

Biological Process

GO:0019725  cellular homeostasis
GO:0032963  collagen metabolic process
GO:0001822  kidney development
GO:0035264  multicellular organism growth
GO:0048871  multicellular organismal homeostasis
GO:0008285  negative regulation of cell proliferation
GO:0014850  response to muscle activity

Cellular Component

GO:0005925  focal adhesion
GO:0005886  plasma membrane

Molecular Function

GO:0046872  metal ion binding
GO:0004721  phosphoprotein phosphatase activity
GO:0005515  protein binding