sirtuin (silent mating type information regulation 2 homolog) 4 (S. cerevisiae)

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Synonym

SIR2-like protein 4, NAD-dependent deacetylase sirtuin-4, MGC57437, SIRT4, SIR2L4, MGC130047, sirtuin 4, MGC130046

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST nodata
GeneChip cerebrum:3.46 cerebellum:3.51 brain stem:3.48 corpus callosum/glia:3.38 pineal gland:- peripheral nerve:3.40 spine:3.29 retina:- eye:- artery/aorta:3.36 vein:3.32 lymphnode:3.39 peripheral blood:- spleen:3.36 thymus:3.41 bone marrow:3.17 adipose:3.33 bone:- skin:3.34
CAGE nodata
RNA-seq cerebrum:0.77 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:1.44 peripheral blood:- spleen:- thymus:- bone marrow:- adipose:0.05 bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST nodata
GeneChip uterus:3.49 placenta:3.21 prostate:3.28 ovary:3.33 testis:4.09 heart:3.72 muscle:4.60 esophagus:3.32 stomach:3.52 intestine:3.58 colon:3.31 liver/hepato:3.77 lung:3.31 bladder:- kidney:3.92 pituitary:3.27 thyroid/parathyroid:3.36 adrenal gland:3.87 pancreas:3.26 breast:3.32 salivary:3.40
CAGE nodata
RNA-seq uterus:- placenta:- prostate:1.10 ovary:0.65 testis:1.75 heart:1.16 muscle:1.47 esophagus:- stomach:- intestine:- colon:1.07     liver/hepato:1.22        lung:0.18    bladder:- kidney:1.54 pituitary:- thyroid/parathyroid:0.77 adrenal gland:0.39 pancreas:- breast:0.95 salivary:-

Gene Information

IDs

Refseq ID NM_012240
Gene ID 23409
Unigene ID -
Probe set ID 220047_at  [HG-U133_Plus_2]
Ensembl ID ENSG00000089163
GTEx ID ENSG00000089163

Orthologous Gene

Mouse[2]  NM_001167691, NM_133760
Rat[1]  NM_001107147, NM_133760

Chromosomal Region

12q24.31  [120,740,119  -  120,751,052]

Gene Family (Interpro ID)

IPR003000  NAD-dependent histone deacetylase, silent information regulator Sir2

Link to Pubmed  (Pubmed ID)

9847074
10381378
10873683
12477932
15122253
15342556
15489334
16079181
16541075
16959573
17456799
17715127
19209188
21556116
22770219
23044393
23045395
23663782
24250222
24368766

Gene Ontology  (GO ID)

Biological Process

GO:0006342  chromatin silencing
GO:0006541  glutamine metabolic process
GO:0046322  negative regulation of fatty acid oxidation
GO:0046676  negative regulation of insulin secretion
GO:0034983  peptidyl-lysine deacetylation
GO:0046889  positive regulation of lipid biosynthetic process
GO:0006471  protein amino acid ADP-ribosylation
GO:0006974  response to DNA damage stimulus

Cellular Component

GO:0005759  mitochondrial matrix
GO:0005739  mitochondrion

Molecular Function

GO:0070403  NAD binding
GO:0003950  NAD+ ADP-ribosyltransferase activity
GO:0034979  NAD-dependent protein deacetylase activity
GO:0005515  protein binding
GO:0008270  zinc ion binding