frataxin

Synonym

FRDA, FARR, FXN, FA, Fxn, Friedreich ataxia, MGC57199, Frataxin, mitochondrial precursor, Friedreich ataxia protein, CyaY, X25, frataxin

normal 40 tissues
cell lines, primary cells, adult tissues and fetal tissues (FANTOM5 CAGE)

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain

blood

connective

EST

cerebrum:9.50

cerebellum:-

brain stem:-

corpus callosum/glia:-

pineal gland:-

peripheral nerve:-

spine:-

retina:-

eye:5.90

artery/aorta:-

vein:-

lymphnode:-

peripheral blood:-

spleen:-

thymus:-

bone marrow:-

adipose:-

bone:-

skin:4.80

GeneChip

cerebrum:4.18

cerebellum:4.22

brain stem:4.20

corpus callosum/glia:4.31

pineal gland:-

peripheral nerve:4.33

spine:4.29

retina:-

eye:-

artery/aorta:4.39

vein:4.36

lymphnode:4.71

peripheral blood:-

spleen:4.72

thymus:4.11

bone marrow:5.28

adipose:4.43

bone:-

skin:4.26

CAGE

cerebrum:2.76

cerebellum:-

brain stem:2.88

corpus callosum/glia:2.98

pineal gland:2.64

peripheral nerve:-

spine:2.78

retina:-

eye:-

artery/aorta:2.46

vein:2.83

lymphnode:2.87

peripheral blood:-

spleen:2.83

thymus:1.84

bone marrow:-

adipose:2.63

bone:-

skin:-

RNA-seq

cerebrum:0.23

cerebellum:-

brain stem:-

corpus callosum/glia:-

pineal gland:-

peripheral nerve:-

spine:-

retina:-

eye:-

artery/aorta:-

vein:-

lymphnode:0.51

peripheral blood:-

spleen:-

thymus:-

bone marrow:-

adipose:0.00

bone:-

skin:-

reproductive

muscular

alimentary

liver

lung

urinary

endo/exo-crine

EST

uterus:-

placenta:3.60

prostate:11.30

ovary:-

testis:-

heart:12.80

muscle:-

esophagus:-

stomach:-

intestine:-

colon:8.50

liver/hepato:-

lung:-

bladder:-

kidney:-

pituitary:-

thyroid/parathyroid:-

adrenal gland:-

pancreas:-

breast:-

salivary:-

GeneChip

uterus:4.84

placenta:4

prostate:4.77

ovary:4.74

testis:5.01

heart:5.08

muscle:5.06

esophagus:4.41

stomach:4.74

intestine:4.78

colon:4.91

liver/hepato:5.80

lung:4.17

bladder:-

kidney:4.56

pituitary:4.27

thyroid/parathyroid:4.51

adrenal gland:5.16

pancreas:4.78

breast:4.39

salivary:4.89

CAGE

uterus:2.71

placenta:2.21

prostate:2.83

ovary:3.11

testis:3.04

heart:3.36

muscle:3.37

esophagus:2.54

stomach:-

intestine:2.04

colon:2.57

liver/hepato:3.62

lung:2.58

bladder:2.85

kidney:2.64

pituitary:2.73

thyroid/parathyroid:2.82

adrenal gland:-

pancreas:3.57

breast:2.95

salivary:3.05

RNA-seq

uterus:-

placenta:-

prostate:0.00

ovary:0.51

testis:0.39

heart:0.36

muscle:0.00

esophagus:-

stomach:-

intestine:-

colon:0.00

liver/hepato:0.26

lung:0.00

bladder:-

kidney:0.23

pituitary:-

thyroid/parathyroid:0.00

adrenal gland:0.05

pancreas:-

breast:0.00

salivary:-

IDs

Refseq ID	NM_181425
Gene ID	2395
Unigene ID	Hs.20685
Probe set ID	205565_s_at [HG-U133_Plus_2]
Ensembl ID	ENSG00000165060
GTEx ID	ENSG00000165060

Orthologous Gene

Mouse[1]	NM_008044
Rat [0]

Chromosomal Region

9q21.11 [71,650,175 - 71,715,094]

Search genes near this gene
- Between -5kb and +5kb
- Between -10kb and +10kb

Gene Family (Interpro ID)

IPR017789	Frataxin
IPR001794	Frataxin, subgroup
IPR002908	Frataxin-like

Gene Ontology (GO ID)

Biological Process

GO:0007628	adult walking behavior
GO:0009060	aerobic respiration
GO:0006879	cellular iron ion homeostasis
GO:0070301	cellular response to hydrogen peroxide
GO:0009792	embryonic development ending in birth or egg hatching
GO:0006783	heme biosynthetic process
GO:0006811	ion transport
GO:0018283	iron incorporation into metallo-sulfur cluster
GO:0007005	mitochondrion organization
GO:0043066	negative regulation of apoptosis
GO:0040015	negative regulation of multicellular organism growth
GO:0046621	negative regulation of organ growth
GO:0090201	negative regulation of release of cytochrome c from mitochondria
GO:0006119	oxidative phosphorylation
GO:0045773	positive regulation of axon extension
GO:0030307	positive regulation of cell growth
GO:0008284	positive regulation of cell proliferation
GO:0051349	positive regulation of lyase activity
GO:0048554	positive regulation of metalloenzyme activity
GO:0051353	positive regulation of oxidoreductase activity
GO:0051347	positive regulation of transferase activity
GO:0019230	proprioception
GO:0016540	protein autoprocessing
GO:0010722	regulation of ferrochelatase activity
GO:0042493	response to drug
GO:0010039	response to iron ion
GO:0014070	response to organic cyclic substance

Cellular Component

GO:0005829	cytosol
GO:0005759	mitochondrial matrix
GO:0005739	mitochondrion

Molecular Function

GO:0051537	2 iron, 2 sulfur cluster binding
GO:0019899	enzyme binding
GO:0008199	ferric iron binding
GO:0008198	ferrous iron binding
GO:0004322	ferroxidase activity
GO:0034986	iron chaperone activity
GO:0051536	iron-sulfur cluster binding
GO:0005515	protein binding

frataxin

Synonym

Expression Pattern

Choropleth map on BodyParts3D

Classification in 40 Organs

Gene Information

IDs

Orthologous Gene

Chromosomal Region

Gene Family (Interpro ID)

Link to Pubmed (Pubmed ID)

Gene Ontology (GO ID)

Biological Process

Cellular Component

Molecular Function