pleckstrin homology domain containing, family G (with RhoGef domain) member 3

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Synonym

KIAA0599, PLEKHG3

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:8.30 cerebellum:25.20 brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:30.70 spine:- retina:- eye:23.50 artery/aorta:- vein:- lymphnode:20.20 peripheral blood:18.20 spleen:18.90 thymus:- bone marrow:78.70 adipose:80.70 bone:12.80 skin:19.20
GeneChip cerebrum:6.12 cerebellum:6.40 brain stem:6.15 corpus callosum/glia:6.85 pineal gland:- peripheral nerve:5.79 spine:5.90 retina:- eye:- artery/aorta:5.87 vein:5.84 lymphnode:5.56 peripheral blood:- spleen:6.04 thymus:5.07 bone marrow:5.80 adipose:5.72 bone:- skin:5.83
CAGE cerebrum:3.67 cerebellum:- brain stem:4.29 corpus callosum/glia:5.19 pineal gland:1.73 peripheral nerve:- spine:3.97 retina:- eye:- artery/aorta:4.03 vein:2.69 lymphnode:2.53 peripheral blood:- spleen:2.83 thymus:1.41 bone marrow:- adipose:3.15 bone:- skin:-
RNA-seq cerebrum:3.19 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:2.14 peripheral blood:- spleen:- thymus:- bone marrow:- adipose:2.52 bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:- placenta:40.10 prostate:56.30 ovary:37.30 testis:13 heart:63.90 muscle:- esophagus:- stomach:- intestine:- colon:42.40     liver/hepato:10.60        lung:19.60    bladder:- kidney:93.60 pituitary:- thyroid/parathyroid:- adrenal gland:- pancreas:8.90 breast:9.30 salivary:-
GeneChip uterus:5.98 placenta:5.76 prostate:5.46 ovary:5.67 testis:4.95 heart:5.76 muscle:6.25 esophagus:5.93 stomach:5.65 intestine:6 colon:6.19 liver/hepato:5.99 lung:5.58 bladder:- kidney:6.53 pituitary:5.31 thyroid/parathyroid:6.01 adrenal gland:5.46 pancreas:6.08 breast:5.71 salivary:6.20
CAGE uterus:3.79 placenta:3.54 prostate:3.31 ovary:3.62 testis:2.73 heart:2.84 muscle:2.55 esophagus:3.71 stomach:- intestine:2.71 colon:3.83     liver/hepato:3.16    lung:2.75 bladder:3.61 kidney:3.39 pituitary:0.95 thyroid/parathyroid:3.00 adrenal gland:- pancreas:3.75 breast:4.01 salivary:3.37
RNA-seq uterus:- placenta:- prostate:3.38 ovary:3.55 testis:2.76 heart:0.99 muscle:1.32 esophagus:- stomach:- intestine:- colon:2.68     liver/hepato:1.59        lung:2.05    bladder:- kidney:3.13 pituitary:- thyroid/parathyroid:2.64 adrenal gland:2.51 pancreas:- breast:2.37 salivary:-

Gene Information

IDs

Refseq ID NM_015549
Gene ID 26030
Unigene ID Hs.509637
Probe set ID 212821_at  [HG-U133_Plus_2]
Ensembl ID ENSG00000126822
GTEx ID ENSG00000126822

Orthologous Gene

Mouse[1]  NM_153804
Rat[1]  NM_153804

Chromosomal Region

14q23.3  [65,170,820  -  65,213,610]

Gene Family (Interpro ID)

IPR001849  Pleckstrin homology

Link to Pubmed  (Pubmed ID)

9628581
12477932
21139048
21360829
23000965

Gene Ontology  (GO ID)

Biological Process

GO:0035023  regulation of Rho protein signal transduction

Molecular Function

GO:0005543  phospholipid binding
GO:0005089  Rho guanyl-nucleotide exchange factor activity