hairy/enhancer-of-split related with YRPW motif-like

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Synonym

HEYL, MGC12623, HRT3

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:14.20 cerebellum:- brain stem:6535.90 corpus callosum/glia:- pineal gland:- peripheral nerve:30.70 spine:- retina:- eye:76.40 artery/aorta:- vein:- lymphnode:- peripheral blood:- spleen:18.90 thymus:- bone marrow:- adipose:- bone:- skin:-
GeneChip cerebrum:5.58 cerebellum:5.67 brain stem:5.66 corpus callosum/glia:5.40 pineal gland:- peripheral nerve:5.30 spine:5.28 retina:- eye:- artery/aorta:5.77 vein:5.83 lymphnode:5.34 peripheral blood:- spleen:5.11 thymus:5.27 bone marrow:5.56 adipose:5.57 bone:- skin:5.60
CAGE cerebrum:2.24 cerebellum:- brain stem:2.63 corpus callosum/glia:2.31 pineal gland:4.20 peripheral nerve:- spine:2.31 retina:- eye:- artery/aorta:4.94 vein:3.64 lymphnode:2.00 peripheral blood:- spleen:2.70 thymus:0.64 bone marrow:- adipose:3.20 bone:- skin:-
RNA-seq cerebrum:1.36 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:2.29 peripheral blood:- spleen:- thymus:- bone marrow:- adipose:3.59 bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:36.50 placenta:87.40 prostate:45.10 ovary:37.30 testis:69.20 heart:102.20 muscle:- esophagus:- stomach:- intestine:- colon:50.90     liver/hepato:-        lung:19.60    bladder:- kidney:20.80 pituitary:- thyroid/parathyroid:- adrenal gland:- pancreas:80 breast:18.60 salivary:-
GeneChip uterus:5.34 placenta:5.25 prostate:5.23 ovary:5.43 testis:5.33 heart:5.55 muscle:5.82 esophagus:5.59 stomach:5.35 intestine:5.69 colon:5.57 liver/hepato:5.48 lung:5.44 bladder:- kidney:5.47 pituitary:5.51 thyroid/parathyroid:5.36 adrenal gland:5.47 pancreas:5.93 breast:5.30 salivary:5.68
CAGE uterus:4.04 placenta:3.70 prostate:3.00 ovary:3.72 testis:4.39 heart:4.17 muscle:3.03 esophagus:2.58 stomach:- intestine:2.20 colon:2.35     liver/hepato:2.27    lung:3.74 bladder:2.92 kidney:3.51 pituitary:1.99 thyroid/parathyroid:3.40 adrenal gland:- pancreas:5.10 breast:2.99 salivary:1.82
RNA-seq uterus:- placenta:- prostate:1.63 ovary:2.86 testis:4.57 heart:2.81 muscle:1.01 esophagus:- stomach:- intestine:- colon:1.99     liver/hepato:1.01        lung:2.84    bladder:- kidney:2.73 pituitary:- thyroid/parathyroid:2.59 adrenal gland:2.48 pancreas:- breast:1.86 salivary:-

Gene Information

IDs

Refseq ID NM_014571
Gene ID 26508
Unigene ID Hs.472566
Probe set ID 220662_s_at  [HG-U133_Plus_2]
Ensembl ID ENSG00000163909
GTEx ID ENSG00000163909

Orthologous Gene

Mouse[3]  NM_013905
Rat[1]  NM_001107977

Chromosomal Region

1p34.2  [40,089,825  -  40,105,617]

Gene Family (Interpro ID)

IPR003650  Orange
IPR018352  Orange subgroup

Link to Pubmed  (Pubmed ID)

8889548
10415358
10860664
10924525
10964718
11095750
12477932
12548545
15231748
15485867
16165016
16189514
17611704
20211142
21290414
21454491
21832049
21906983
23222517
23275563

Gene Ontology  (GO ID)

Biological Process

GO:0003181  atrioventricular valve morphogenesis
GO:0060317  cardiac epithelial to mesenchymal transition
GO:0003208  cardiac ventricle morphogenesis
GO:0003203  endocardial cushion morphogenesis
GO:0003198  epithelial to mesenchymal transition involved in endocardial cushion formation
GO:0032835  glomerulus development
GO:0014031  mesenchymal cell development
GO:0060766  negative regulation of androgen receptor signaling pathway
GO:0045892  negative regulation of transcription, DNA-dependent
GO:0007219  Notch signaling pathway
GO:0003151  outflow tract morphogenesis
GO:0045666  positive regulation of neuron differentiation
GO:0045944  positive regulation of transcription from RNA polymerase II promoter
GO:0003184  pulmonary valve morphogenesis
GO:0060412  ventricular septum morphogenesis

Cellular Component

GO:0005737  cytoplasm
GO:0005654  nucleoplasm
GO:0005634  nucleus

Molecular Function

GO:0050683  AF-1 domain binding
GO:0005515  protein binding
GO:0046982  protein heterodimerization activity
GO:0042803  protein homodimerization activity
GO:0003714  transcription corepressor activity
GO:0003700  transcription factor activity
GO:0008134  transcription factor binding