glutaminase 2 (liver, mitochondrial)

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Synonym

hLGA, glutaminase 2 (liver, mitochondrial), LGA, GLS, GLS2, GA, L-glutaminase, MGC71567, Glutaminase liver isoform, mitochondrial precursor, L-glutamine amidohydrolase

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:61.60 cerebellum:151.10 brain stem:- corpus callosum/glia:29.20 pineal gland:- peripheral nerve:- spine:- retina:118.60 eye:23.50 artery/aorta:- vein:- lymphnode:- peripheral blood:- spleen:- thymus:- bone marrow:- adipose:- bone:- skin:4.80
GeneChip cerebrum:6.25 cerebellum:7.11 brain stem:6.06 corpus callosum/glia:4.83 pineal gland:- peripheral nerve:5 spine:5.43 retina:- eye:- artery/aorta:4.67 vein:4.77 lymphnode:5.03 peripheral blood:- spleen:4.69 thymus:4.40 bone marrow:4.81 adipose:4.83 bone:- skin:5.08
CAGE cerebrum:3.45 cerebellum:- brain stem:2.19 corpus callosum/glia:1.55 pineal gland:2.99 peripheral nerve:- spine:2.43 retina:- eye:- artery/aorta:0.95 vein:1.10 lymphnode:1.15 peripheral blood:- spleen:0.61 thymus:0.57 bone marrow:- adipose:0.36 bone:- skin:-
RNA-seq cerebrum:2.70 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:0.86 peripheral blood:- spleen:- thymus:- bone marrow:- adipose:0.13 bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:- placenta:- prostate:56.30 ovary:- testis:8.70 heart:12.80 muscle:- esophagus:- stomach:- intestine:- colon:-     liver/hepato:84.40        lung:4.90    bladder:- kidney:20.80 pituitary:- thyroid/parathyroid:- adrenal gland:- pancreas:- breast:18.60 salivary:-
GeneChip uterus:4.56 placenta:4.65 prostate:4.92 ovary:4.92 testis:4.73 heart:4.76 muscle:4.95 esophagus:5.24 stomach:4.84 intestine:5.24 colon:4.87 liver/hepato:9.10 lung:4.65 bladder:- kidney:5.29 pituitary:6.54 thyroid/parathyroid:4.67 adrenal gland:4.72 pancreas:7.92 breast:4.97 salivary:5.40
CAGE uterus:1.15 placenta:0 prostate:1.51 ovary:1.23 testis:1.06 heart:0.34 muscle:0.30 esophagus:1.20 stomach:- intestine:0.48 colon:0.98     liver/hepato:4.87    lung:1.42 bladder:0.83 kidney:1.09 pituitary:3.35 thyroid/parathyroid:1.50 adrenal gland:- pancreas:3.96 breast:0.55 salivary:1.28
RNA-seq uterus:- placenta:- prostate:1.56 ovary:1.04 testis:0.69 heart:0.17 muscle:0.08 esophagus:- stomach:- intestine:- colon:0.28     liver/hepato:4.86        lung:0.44    bladder:- kidney:1.20 pituitary:- thyroid/parathyroid:1.52 adrenal gland:0.93 pancreas:- breast:0.31 salivary:-

Gene Information

IDs

Refseq ID NM_013267
Gene ID 27165
Unigene ID Hs.212606
Probe set ID 205531_s_at  [HG-U133_Plus_2]
Ensembl ID ENSG00000135423
GTEx ID ENSG00000135423

Orthologous Gene

Mouse[1]  NM_001033264
Rat [0]  

Chromosomal Region

12q13.3  [56,864,736  -  56,882,198]

Gene Family (Interpro ID)

IPR012338  Beta-lactamase-type transpeptidase fold
IPR015868  Glutaminase, core

Link to Pubmed  (Pubmed ID)

8619474
9110174
10620514
11130979
11163757
12163477
12444921
12477932
14675161
15123239
15496140
16344560
16637659
17669570
18088378
19062176
20351271
20378837
20877624
21886157
21988832
22049910
22286219
22679499
22888977
22916037
23574722
23954443
24096582
24144296
24330717

Gene Ontology  (GO ID)

Biological Process

GO:0008652  cellular amino acid biosynthetic process
GO:0006520  cellular amino acid metabolic process
GO:0034641  cellular nitrogen compound metabolic process
GO:0014047  glutamate secretion
GO:0006541  glutamine metabolic process
GO:0007269  neurotransmitter secretion
GO:0042981  regulation of apoptosis
GO:0007268  synaptic transmission

Cellular Component

GO:0005759  mitochondrial matrix
GO:0005739  mitochondrion

Molecular Function

GO:0004359  glutaminase activity
GO:0005515  protein binding