signaling threshold regulating transmembrane adaptor 1

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Synonym

MGC125909, Suppression-inducing transmembrane adapter 1, SIT, MGC125910, gp30/40, RP11-331F9.5, MGC125908, SHP2-interacting transmembrane adapter protein, SIT1, suppression inducing transmembrane adaptor 1

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:- cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:101.10 peripheral blood:18.20 spleen:18.90 thymus:38.70 bone marrow:- adipose:- bone:- skin:-
GeneChip cerebrum:4.96 cerebellum:5.15 brain stem:4.90 corpus callosum/glia:4.94 pineal gland:- peripheral nerve:4.81 spine:4.71 retina:- eye:- artery/aorta:4.88 vein:5.26 lymphnode:6.21 peripheral blood:- spleen:5.77 thymus:7.01 bone marrow:5.38 adipose:5.22 bone:- skin:5.07
CAGE cerebrum:0.02 cerebellum:- brain stem:0.07 corpus callosum/glia:0.29 pineal gland:0 peripheral nerve:- spine:0.30 retina:- eye:- artery/aorta:0.69 vein:3.81 lymphnode:3.25 peripheral blood:- spleen:3.42 thymus:4.81 bone marrow:- adipose:0.14 bone:- skin:-
RNA-seq cerebrum:0.01 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:3.95 peripheral blood:- spleen:- thymus:- bone marrow:- adipose:0.14 bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:- placenta:- prostate:- ovary:- testis:4.30 heart:- muscle:- esophagus:- stomach:- intestine:- colon:8.50     liver/hepato:-        lung:-    bladder:- kidney:- pituitary:- thyroid/parathyroid:- adrenal gland:- pancreas:- breast:- salivary:-
GeneChip uterus:4.81 placenta:5.22 prostate:4.57 ovary:4.92 testis:4.53 heart:5.20 muscle:5.27 esophagus:5.15 stomach:5.28 intestine:5.19 colon:5.41 liver/hepato:5.05 lung:5.12 bladder:- kidney:5.01 pituitary:4.90 thyroid/parathyroid:4.84 adrenal gland:4.87 pancreas:5.38 breast:4.78 salivary:5.23
CAGE uterus:0.71 placenta:0.16 prostate:0.58 ovary:0.42 testis:0.24 heart:0.19 muscle:0.30 esophagus:1.39 stomach:- intestine:1.60 colon:1.09     liver/hepato:0    lung:1.24 bladder:0.83 kidney:0.62 pituitary:0 thyroid/parathyroid:0.49 adrenal gland:- pancreas:0 breast:0 salivary:1.49
RNA-seq uterus:- placenta:- prostate:0.28 ovary:0.35 testis:0.13 heart:0.05 muscle:0 esophagus:- stomach:- intestine:- colon:0.34     liver/hepato:0.17        lung:0.88    bladder:- kidney:0.16 pituitary:- thyroid/parathyroid:0.28 adrenal gland:3.63 pancreas:- breast:0.50 salivary:-

Gene Information

IDs

Refseq ID NM_014450
Gene ID 27240
Unigene ID Hs.88012
Probe set ID 205484_at  [HG-U133_Plus_2]
Ensembl ID ENSG00000137078
GTEx ID ENSG00000137078

Orthologous Gene

Mouse[1]  NM_019436
Rat[1]  NM_001024344

Chromosomal Region

9p13.3  [35,649,292  -  35,650,937]

Gene Family (Interpro ID)

-

Link to Pubmed  (Pubmed ID)

7566098
10209036
11390434
11433379
11491537
12477932
15144186
15164053
15489334
15570572
15592455
16094384
16160011
18029348
19204726
21957439
22505724
23648065
24250222

Gene Ontology  (GO ID)

Biological Process

GO:0050863  regulation of T cell activation
GO:0007165  signal transduction

Cellular Component

GO:0005737  cytoplasm
GO:0005887  integral to plasma membrane
GO:0005730  nucleolus
GO:0005886  plasma membrane

Molecular Function

GO:0019900  kinase binding
GO:0005515  protein binding
GO:0042169  SH2 domain binding