major histocompatibility complex, class I-related

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Synonym

major histocompatibility complex, class I-related, MR1, HLALS

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:2.40 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:20.20 peripheral blood:18.20 spleen:- thymus:12.90 bone marrow:78.70 adipose:- bone:- skin:14.40
GeneChip cerebrum:5.46 cerebellum:5.38 brain stem:5.56 corpus callosum/glia:5.53 pineal gland:- peripheral nerve:5.79 spine:5.61 retina:- eye:- artery/aorta:5.98 vein:6.06 lymphnode:5.62 peripheral blood:- spleen:5.70 thymus:5.82 bone marrow:6.15 adipose:5.99 bone:- skin:5.76
CAGE cerebrum:1.21 cerebellum:- brain stem:1.23 corpus callosum/glia:1.47 pineal gland:1.12 peripheral nerve:- spine:1.71 retina:- eye:- artery/aorta:2.84 vein:2.13 lymphnode:2.47 peripheral blood:- spleen:2.32 thymus:2.62 bone marrow:- adipose:2.12 bone:- skin:-
RNA-seq cerebrum:0.47 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:2.22 peripheral blood:- spleen:- thymus:- bone marrow:- adipose:0.52 bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:- placenta:29.10 prostate:11.30 ovary:- testis:4.30 heart:- muscle:- esophagus:- stomach:- intestine:32.40 colon:8.50     liver/hepato:-        lung:9.80    bladder:- kidney:31.20 pituitary:116 thyroid/parathyroid:- adrenal gland:- pancreas:- breast:9.30 salivary:-
GeneChip uterus:5.71 placenta:5.39 prostate:5.66 ovary:5.82 testis:5.03 heart:6.09 muscle:5.73 esophagus:5.65 stomach:5.73 intestine:5.93 colon:6.04 liver/hepato:5.52 lung:6.05 bladder:- kidney:5.77 pituitary:6.08 thyroid/parathyroid:5.63 adrenal gland:5.80 pancreas:5.76 breast:5.72 salivary:5.46
CAGE uterus:1.83 placenta:2.11 prostate:2.28 ovary:2.33 testis:1.10 heart:1.61 muscle:0.87 esophagus:2.18 stomach:- intestine:1.63 colon:1.73     liver/hepato:1.93    lung:2.54 bladder:2.23 kidney:2.03 pituitary:2.51 thyroid/parathyroid:2.20 adrenal gland:- pancreas:1.42 breast:1.92 salivary:0.83
RNA-seq uterus:- placenta:- prostate:1.54 ovary:1.20 testis:0.78 heart:0.42 muscle:0 esophagus:- stomach:- intestine:- colon:0.93     liver/hepato:0.34        lung:1.88    bladder:- kidney:1.52 pituitary:- thyroid/parathyroid:1.08 adrenal gland:0.85 pancreas:- breast:0.70 salivary:-

Gene Information

IDs

Refseq ID NM_001531
Gene ID 3140
Unigene ID Hs.101840
Probe set ID 210223_s_at  [HG-U133_Plus_2]
Ensembl ID ENSG00000153029
GTEx ID ENSG00000153029

Orthologous Gene

Mouse[2]  NM_008209
Rat [0]  

Chromosomal Region

1q25.3  [181,003,067  -  181,031,074]

Gene Family (Interpro ID)

IPR001039  MHC class I, alpha chain, alpha1/alpha2
IPR011161  MHC class I-like antigen recognition
IPR011162  MHC classes I/II-like antigen recognition protein

Link to Pubmed  (Pubmed ID)

7624800
8125298
9325151
9780177
9784382
10708443
11019920
12477932
12794138
14702039
18068122
18187620
19416870
19460752
19706888
19760593
20237496
21190736
21777569
22412157
22692454
23051753
23457030
24101382

Gene Ontology  (GO ID)

Biological Process

GO:0002474  antigen processing and presentation of peptide antigen via MHC class I
GO:0002367  cytokine production during immune response
GO:0050829  defense response to Gram-negative bacterium
GO:0006955  immune response
GO:0032611  interleukin-1 beta production
GO:0032620  interleukin-17 production
GO:0001916  positive regulation of T cell mediated cytotoxicity

Cellular Component

GO:0005783  endoplasmic reticulum
GO:0005576  extracellular region
GO:0016021  integral to membrane
GO:0042612  MHC class I protein complex

Molecular Function

GO:0032393  MHC class I receptor activity
GO:0042605  peptide antigen binding