DnaJ (Hsp40) homolog, subfamily B, member 2

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Synonym

DNAJB2, HSJ-1, HSPF3, DnaJ protein homolog 1, Heat shock 40 kDa protein 3, DnaJ (Hsp40) homolog, subfamily B, member 2, HSJ1, DnaJ homolog subfamily B member 2

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:92.40 cerebellum:12.60 brain stem:- corpus callosum/glia:29.20 pineal gland:- peripheral nerve:- spine:336.90 retina:- eye:152.80 artery/aorta:- vein:- lymphnode:91 peripheral blood:18.20 spleen:18.90 thymus:38.70 bone marrow:39.40 adipose:121 bone:89.60 skin:48
GeneChip cerebrum:8.27 cerebellum:8.03 brain stem:8.21 corpus callosum/glia:9.27 pineal gland:- peripheral nerve:8.21 spine:8.61 retina:- eye:- artery/aorta:7.33 vein:6.79 lymphnode:7.20 peripheral blood:- spleen:7.22 thymus:6.52 bone marrow:7.09 adipose:7.03 bone:- skin:7.24
CAGE cerebrum:5.32 cerebellum:- brain stem:5.50 corpus callosum/glia:5.61 pineal gland:5.82 peripheral nerve:- spine:5.68 retina:- eye:- artery/aorta:4.26 vein:3.92 lymphnode:3.75 peripheral blood:- spleen:3.51 thymus:3.25 bone marrow:- adipose:3.78 bone:- skin:-
RNA-seq cerebrum:3.66 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:3.22 peripheral blood:- spleen:- thymus:- bone marrow:- adipose:2.41 bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:- placenta:69.20 prostate:45.10 ovary:37.30 testis:30.30 heart:12.80 muscle:40.20 esophagus:- stomach:21.20 intestine:- colon:33.90     liver/hepato:31.70        lung:29.30    bladder:125.60 kidney:41.60 pituitary:116 thyroid/parathyroid:- adrenal gland:- pancreas:62.20 breast:46.50 salivary:-
GeneChip uterus:6.77 placenta:7.14 prostate:7.36 ovary:7.11 testis:7.86 heart:6.88 muscle:7.55 esophagus:7.53 stomach:7.04 intestine:6.62 colon:6.63 liver/hepato:7.15 lung:7.51 bladder:- kidney:7.53 pituitary:8.15 thyroid/parathyroid:7.94 adrenal gland:7.81 pancreas:7.15 breast:7.51 salivary:7.55
CAGE uterus:4.17 placenta:4.11 prostate:4.51 ovary:4.11 testis:4.26 heart:4.26 muscle:4.61 esophagus:4.23 stomach:- intestine:3.53 colon:4.06     liver/hepato:3.79    lung:4.06 bladder:4.25 kidney:4.19 pituitary:4.55 thyroid/parathyroid:4.83 adrenal gland:- pancreas:4.63 breast:4.77 salivary:4.75
RNA-seq uterus:- placenta:- prostate:3.41 ovary:3.14 testis:3.00 heart:1.55 muscle:1.97 esophagus:- stomach:- intestine:- colon:3.21     liver/hepato:1.08        lung:2.58    bladder:- kidney:2.02 pituitary:- thyroid/parathyroid:3.53 adrenal gland:2.14 pancreas:- breast:2.58 salivary:-

Gene Information

IDs

Refseq ID NM_006736
Gene ID 3300
Unigene ID Hs.77768
Probe set ID 202500_at  [HG-U133_Plus_2]
Ensembl ID ENSG00000135924
GTEx ID ENSG00000135924

Orthologous Gene

Mouse[5]  NM_001159883, NM_001159884, NM_001159885, NM_020266, NM_178055
Rat[1]  NM_001109541, NM_001159884, NM_001159885, NM_020266, NM_178055

Chromosomal Region

2q35  [220,143,989  -  220,151,622]

Gene Family (Interpro ID)

IPR003095  Heat shock protein DnaJ
IPR015609  Molecular chaperone, heat shock protein, Hsp40, DnaJ

Link to Pubmed  (Pubmed ID)

1599432
8889548
9553041
10516435
11147971
12107410
12477932
12754272
14751250
14759258
15231748
15489334
15936278
16604191
17082820
17207965
17601350
17847007
18321953
18977241
19285159
20395441
21139048
21625540
21890473
21906983
21963094
21987572
22190034
22396390
22522442
23000965
23752268
23940030
24023695
24250222

Gene Ontology  (GO ID)

Biological Process

GO:0008219  cell death
GO:0030433  ER-associated protein catabolic process
GO:0030308  negative regulation of cell growth
GO:0008285  negative regulation of cell proliferation
GO:0090084  negative regulation of inclusion body assembly
GO:0090086  negative regulation of protein deubiquitination
GO:0032436  positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0031398  positive regulation of protein ubiquitination
GO:0006457  protein folding
GO:0006986  response to unfolded protein

Cellular Component

GO:0016234  inclusion body
GO:0000502  proteasome complex

Molecular Function

GO:0030544  Hsp70 protein binding
GO:0031593  polyubiquitin binding
GO:0070628  proteasome binding
GO:0005515  protein binding
GO:0051082  unfolded protein binding