heat shock 60kDa protein 1 (chaperonin)

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Synonym

heat shock 60kD protein 1 (chaperonin), 60 kDa chaperonin, HuCHA60, HSPD1, 60 kDa heat shock protein, mitochondrial precursor, Hsp60, GROEL, HSP-60, HSP60, CPN60, SPG13, Heat shock protein 60, HSP65, Mitochondrial matrix protein P1, spastic paraplegia 13 (autosomal dominant), P60 lymphocyte protein, heat shock 60kDa protein 1 (chaperonin)

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:22.50 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:214.70 spine:112.30 retina:- eye:35.30 artery/aorta:89.90 vein:199.90 lymphnode:151.70 peripheral blood:- spleen:- thymus:51.50 bone marrow:39.40 adipose:121 bone:51.20 skin:43.20
GeneChip cerebrum:9.95 cerebellum:9.61 brain stem:10.21 corpus callosum/glia:10 pineal gland:- peripheral nerve:10.10 spine:10.23 retina:- eye:- artery/aorta:9.99 vein:9.81 lymphnode:10.09 peripheral blood:- spleen:9.56 thymus:10.15 bone marrow:9.73 adipose:10.08 bone:- skin:9.73
CAGE cerebrum:4.44 cerebellum:- brain stem:4.97 corpus callosum/glia:4.47 pineal gland:4.46 peripheral nerve:- spine:5.11 retina:- eye:- artery/aorta:4.64 vein:4.67 lymphnode:4.62 peripheral blood:- spleen:4.69 thymus:4.53 bone marrow:- adipose:4.95 bone:- skin:-
RNA-seq cerebrum:4.79 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:2.28 peripheral blood:- spleen:- thymus:- bone marrow:- adipose:4.29 bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:63.80 placenta:32.80 prostate:11.30 ovary:37.30 testis:13 heart:25.50 muscle:40.20 esophagus:- stomach:361.10 intestine:64.80 colon:169.60     liver/hepato:73.90        lung:4.90    bladder:- kidney:93.60 pituitary:116 thyroid/parathyroid:- adrenal gland:965 pancreas:8.90 breast:92.90 salivary:-
GeneChip uterus:10.06 placenta:9.21 prostate:10.53 ovary:10.67 testis:9.33 heart:9.90 muscle:9.73 esophagus:10.10 stomach:10 intestine:10.25 colon:9.85 liver/hepato:11.04 lung:9.92 bladder:- kidney:10.89 pituitary:10 thyroid/parathyroid:9.81 adrenal gland:12.34 pancreas:10.67 breast:9.81 salivary:9.43
CAGE uterus:4.30 placenta:4.46 prostate:4.90 ovary:4.98 testis:3.91 heart:4.79 muscle:5.06 esophagus:4.89 stomach:- intestine:5.01 colon:4.75     liver/hepato:6.38    lung:4.56 bladder:5.09 kidney:5.54 pituitary:4.69 thyroid/parathyroid:5.16 adrenal gland:- pancreas:5.42 breast:5.66 salivary:3.87
RNA-seq uterus:- placenta:- prostate:0.05 ovary:5.11 testis:5.52 heart:2.98 muscle:2.57 esophagus:- stomach:- intestine:- colon:6.44     liver/hepato:3.32        lung:2.30    bladder:- kidney:6.46 pituitary:- thyroid/parathyroid:6.38 adrenal gland:4.89 pancreas:- breast:5.50 salivary:-

IDs

Refseq ID NM_199440
Gene ID 3329
Unigene ID Hs.595053
Probe set ID 200807_s_at  [HG-U133_Plus_2]
Ensembl ID ENSG00000144381
GTEx ID ENSG00000144381

Orthologous Gene

Mouse[2]  NM_010477
Rat [0]  

Chromosomal Region

Gene Family (Interpro ID)

Link to Pubmed  (Pubmed ID)

1286669
1347942
1516759
1602151
1972619
1980192
2079031
2568584
2907406
7518175
7895732
7907543
7911805
8559246
8671282
8676499
8678928
8689794
8845058
8882520
8976559
8979276
9051195
9150946
9150948
9243807
9724719
9890926
10205158
10205159
10231001
10231004
10326659
10382997
10449265
10467106
10499815
10508170
10632533
10663613
10677329
10731000
10811634
10960671
11050098
11144526
11145923
11230124
11337467
11445587
11488911
11591125
11689615
11777905
11790298
11807771
11860186
11862386
11888933
11898127
11932435
12070120
12105158
12195124
12215374
12218165
12234937
12387818
12406306
12461076
12477932
12483302
12493773
12515899
12552239
12594256
12611882
12665801
12684064
12686536
12768547
12813381
12869561
12890148
12942564
12965262
14500649
14634555
14717702
14968112
15047060
15242332
15249499
15251360
15324660
15371451
15489334
15529360
15546885
15590416
15592455
15618521
15635413
15661886
15763499
15784682
15875659
15879154
15952740
15957980
16009940
16075307
16116071
16130169
16148103
16159877
16196087
16212417
16215457
16236267
16253146
16254226
16320351
16335966
16482509
16705742
16723087
16767222
16843693
16887805
16964243
16978514
17072495
17075864
17110338
17148442
17164250
17174952
17202307
17206383
17314511
17317785
17420921
17420924
17540176
17553457
17584768
17588138
17643375
17670764
17675567
17681147
17823127
17915559
17925998
18029348
18086682
18229457
18240224
18256040
18319262
18320357
18322079
18372523
18399535
18400758
18457437
18458233
18571143
18685789
18692161
18781797
18790094
18815895
18987317
19004824
19008717
19022255
19056867
19106391
19109096
19110265
19132982
19156129
19205928
19207939
19210880
19261350
19264393
19306954
19336475
19338310
19343720
19346294
19369584
19380743
19386281
19423133
19471022
19475432
19565483
19568603
19576649
19635199
19706612
19738201
19764566
19765186
19875724
19913588
19946888
20082317
20169074
20186120
20193073
20301682
20351780
20362058
20471030
20639865
20686813
20694586
20708221
20806039
20877624
20936779
20947377
20953657
20972266
20978188
21081666
21139048
21145461
21319273
21361146
21497776
21642380
21671464
21717087
21726808
21748374
21832049
21840382
21853274
21890473
21906983
21963094
21987572
21988832
22012253
22079093
22140545
22178446
22258649
22268729
22304920
22315307
22319627
22492505
22505724
22575645
22623428
22751105
22753410
22810585
22847064
22848686
22863883
22882677
22901435
22904065
22931585
22933632
22939629
22944692
23000965
23028910
23077236
23125841
23184937
23192457
23246001
23276948
23349634
23357787
23364796
23388486
23398456
23424650
23429486
23438482
23439083
23455922
23466130
23798571
23807299
23823174
23862649
23874603
24015183
24084737
24113772
24123003
24244333
24250222
24337577
24457600
24583282
24591637
24639526
24654937
24680363
24816145

Gene Ontology  (GO ID)

Biological Process

GO:0006458  'de novo' protein folding
GO:0006919  activation of caspase activity
GO:0006200  ATP catabolic process
GO:0042113  B cell activation
GO:0002368  B cell cytokine production
GO:0042100  B cell proliferation
GO:0051131  chaperone-mediated protein complex assembly
GO:0048291  isotype switching to IgG isotypes
GO:0002755  MyD88-dependent toll-like receptor signaling pathway
GO:0043066  negative regulation of apoptosis
GO:0043065  positive regulation of apoptosis
GO:0032727  positive regulation of interferon-alpha production
GO:0032729  positive regulation of interferon-gamma production
GO:0032733  positive regulation of interleukin-10 production
GO:0032735  positive regulation of interleukin-12 production
GO:0032755  positive regulation of interleukin-6 production
GO:0043032  positive regulation of macrophage activation
GO:0050870  positive regulation of T cell activation
GO:0002842  positive regulation of T cell mediated immune response to tumor cell
GO:0051604  protein maturation
GO:0042026  protein refolding
GO:0050821  protein stabilization
GO:0006986  response to unfolded protein
GO:0042110  T cell activation
GO:0019048  virus-host interaction

Cellular Component

GO:0009986  cell surface
GO:0005905  coated pit
GO:0030135  coated vesicle
GO:0019907  cyclin-dependent protein kinase activating kinase holoenzyme complex
GO:0005829  cytosol
GO:0005769  early endosome
GO:0005615  extracellular space
GO:0046696  lipopolysaccharide receptor complex
GO:0005743  mitochondrial inner membrane
GO:0005759  mitochondrial matrix
GO:0005739  mitochondrion
GO:0005886  plasma membrane
GO:0030141  secretory granule

Molecular Function

GO:0005524  ATP binding
GO:0016887  ATPase activity
GO:0051087  chaperone binding
GO:0003688  DNA replication origin binding
GO:0001530  lipopolysaccharide binding
GO:0002039  p53 binding
GO:0005515  protein binding
GO:0003697  single-stranded DNA binding
GO:0051082  unfolded protein binding