isocitrate dehydrogenase 3 (NAD+) beta

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Synonym

H-IDHB, isocitrate dehydrogenase 3 (NAD+) beta, FLJ11043, MGC903, IDH3B

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:101.90 cerebellum:277.10 brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:92 spine:- retina:- eye:99.90 artery/aorta:- vein:- lymphnode:121.30 peripheral blood:164 spleen:56.70 thymus:64.40 bone marrow:59 adipose:161.30 bone:38.40 skin:105.60
GeneChip cerebrum:7.07 cerebellum:7.23 brain stem:7.33 corpus callosum/glia:6.70 pineal gland:- peripheral nerve:7.16 spine:6.77 retina:- eye:- artery/aorta:7.01 vein:6.97 lymphnode:7 peripheral blood:- spleen:6.87 thymus:7.19 bone marrow:6.68 adipose:7.03 bone:- skin:7.23
CAGE cerebrum:4.05 cerebellum:- brain stem:4.01 corpus callosum/glia:3.72 pineal gland:3.45 peripheral nerve:- spine:3.64 retina:- eye:- artery/aorta:3.63 vein:3.91 lymphnode:3.72 peripheral blood:- spleen:3.50 thymus:3.67 bone marrow:- adipose:3.69 bone:- skin:-
RNA-seq cerebrum:0.46 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:2.23 peripheral blood:- spleen:- thymus:- bone marrow:- adipose:0.42 bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:54.70 placenta:98.40 prostate:67.60 ovary:260.80 testis:56.20 heart:76.60 muscle:140.60 esophagus:- stomach:106.20 intestine:64.80 colon:76.30     liver/hepato:63.30        lung:68.40    bladder:- kidney:41.60 pituitary:- thyroid/parathyroid:163.70 adrenal gland:- pancreas:53.30 breast:83.60 salivary:-
GeneChip uterus:6.89 placenta:6.67 prostate:7.01 ovary:6.97 testis:6.64 heart:6.51 muscle:6.67 esophagus:7.14 stomach:6.77 intestine:6.72 colon:7.12 liver/hepato:6.77 lung:6.75 bladder:- kidney:7.29 pituitary:6.59 thyroid/parathyroid:7 adrenal gland:6.79 pancreas:6.39 breast:7.09 salivary:6.97
CAGE uterus:3.70 placenta:3.59 prostate:3.65 ovary:3.53 testis:3.84 heart:4.51 muscle:4.63 esophagus:3.86 stomach:- intestine:4.03 colon:4.07     liver/hepato:3.88    lung:3.47 bladder:3.53 kidney:4.03 pituitary:3.22 thyroid/parathyroid:3.72 adrenal gland:- pancreas:3.32 breast:3.62 salivary:3.97
RNA-seq uterus:- placenta:- prostate:0.71 ovary:0.72 testis:0.25 heart:0.58 muscle:0.00 esophagus:- stomach:- intestine:- colon:0.54     liver/hepato:0.14        lung:0.67    bladder:- kidney:1.36 pituitary:- thyroid/parathyroid:1.38 adrenal gland:1.97 pancreas:- breast:0.61 salivary:-

Gene Information

IDs

Refseq ID NM_174856
Gene ID 3420
Unigene ID Hs.436405
Probe set ID 201509_at  [HG-U133_Plus_2]
Ensembl ID ENSG00000101365
GTEx ID ENSG00000101365

Orthologous Gene

Mouse[2]  NM_130884
Rat[1]  NM_053581

Chromosomal Region

20p13  [2,639,041  -  2,644,865]

Gene Family (Interpro ID)

IPR004434  Isocitrate dehydrogenase NAD-dependent, mitochondrial
IPR001804  Isocitrate/isopropylmalate dehydrogenase

Link to Pubmed  (Pubmed ID)

10575215
10601238
10677231
11780052
12477932
14555658
14702039
15489334
15653693
16169070
16713569
16737955
17314511
17432878
17567985
18457437
18806796
19498431
20301590
20435888
20877624
21139048
21890473
21900206
21906983
22678362
23798571

Gene Ontology  (GO ID)

Biological Process

GO:0006103  2-oxoglutarate metabolic process
GO:0044237  cellular metabolic process
GO:0006102  isocitrate metabolic process
GO:0006734  NADH metabolic process
GO:0006099  tricarboxylic acid cycle

Cellular Component

GO:0005759  mitochondrial matrix
GO:0005739  mitochondrion

Molecular Function

GO:0009055  electron carrier activity
GO:0004449  isocitrate dehydrogenase (NAD+) activity
GO:0000287  magnesium ion binding
GO:0051287  NAD or NADH binding