insulin-like growth factor binding protein 5

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Synonym

IGFBP5, IGFBP-5, IGF-binding protein 5, IBP-5, insulin-like growth factor binding protein 5, IBP5

normal 40 tissues
cell lines, primary cells, adult tissues and fetal tissues (FANTOM5 CAGE)

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain

blood

connective

EST

cerebrum:-

cerebellum:-

brain stem:-

corpus callosum/glia:-

pineal gland:-

peripheral nerve:-

spine:-

retina:-

eye:-

artery/aorta:-

vein:-

lymphnode:-

peripheral blood:-

spleen:-

thymus:-

bone marrow:-

adipose:-

bone:-

skin:-

GeneChip

cerebrum:5.58

cerebellum:5.24

brain stem:5.64

corpus callosum/glia:5.87

pineal gland:-

peripheral nerve:7.01

spine:5.36

retina:-

eye:-

artery/aorta:7.78

vein:7.16

lymphnode:7.41

peripheral blood:-

spleen:5.82

thymus:6.68

bone marrow:5.55

adipose:7.90

bone:-

skin:6.77

CAGE

cerebrum:4.16

cerebellum:-

brain stem:4.36

corpus callosum/glia:5.48

pineal gland:4.91

peripheral nerve:-

spine:4.27

retina:-

eye:-

artery/aorta:6.62

vein:6.37

lymphnode:5.30

peripheral blood:-

spleen:4.58

thymus:2.92

bone marrow:-

adipose:6.36

bone:-

skin:-

RNA-seq

cerebrum:5.01

cerebellum:-

brain stem:-

corpus callosum/glia:-

pineal gland:-

peripheral nerve:-

spine:-

retina:-

eye:-

artery/aorta:-

vein:-

lymphnode:6.99

peripheral blood:-

spleen:-

thymus:-

bone marrow:-

adipose:8.16

bone:-

skin:-

reproductive

muscular

alimentary

liver

lung

urinary

endo/exo-crine

EST

uterus:-

placenta:-

prostate:-

ovary:-

testis:-

heart:-

muscle:-

esophagus:-

stomach:-

intestine:-

colon:-

liver/hepato:-

lung:4.90

bladder:-

kidney:10.40

pituitary:-

thyroid/parathyroid:-

adrenal gland:-

pancreas:-

breast:-

salivary:-

GeneChip

uterus:7.90

placenta:6.22

prostate:7.64

ovary:7.81

testis:5.42

heart:7.15

muscle:6.59

esophagus:7.38

stomach:7.57

intestine:5.95

colon:6.31

liver/hepato:6.01

lung:5.51

bladder:-

kidney:8.27

pituitary:8.06

thyroid/parathyroid:8.49

adrenal gland:9.79

pancreas:5.91

breast:7.86

salivary:6.72

CAGE

uterus:7.29

placenta:5.84

prostate:6.04

ovary:8.00

testis:5.59

heart:5.71

muscle:4.99

esophagus:5.97

stomach:-

intestine:5.12

colon:5.56

liver/hepato:4.46

lung:4.97

bladder:5.88

kidney:6.00

pituitary:5.81

thyroid/parathyroid:7.30

adrenal gland:-

pancreas:3.50

breast:6.29

salivary:4.75

RNA-seq

uterus:-

placenta:-

prostate:7.19

ovary:10.02

testis:7.57

heart:5.21

muscle:5.54

esophagus:-

stomach:-

intestine:-

colon:7.18

liver/hepato:4.20

lung:5.56

bladder:-

kidney:6.71

pituitary:-

thyroid/parathyroid:8.62

adrenal gland:7.22

pancreas:-

breast:6.83

salivary:-

IDs

Refseq ID	NM_000599
Gene ID	3488
Unigene ID	Hs.607212
Probe set ID	203424_s_at [HG-U133_Plus_2]
Ensembl ID	ENSG00000115461
GTEx ID	ENSG00000115461

Orthologous Gene

Mouse[2]	NM_010518
Rat [0]

Chromosomal Region

2q35 [217,536,828 - 217,560,248]

Search genes near this gene
- Between -5kb and +5kb
- Between -10kb and +10kb

Gene Family (Interpro ID)

IPR009168	Insulin-like growth factor binding protein
IPR012213	Insulin-like growth factor binding protein 5

Gene Ontology (GO ID)

Biological Process

GO:0044267	cellular protein metabolic process
GO:0071320	cellular response to cAMP
GO:0071407	cellular response to organic cyclic substance
GO:0042593	glucose homeostasis
GO:0006006	glucose metabolic process
GO:0031069	hair follicle morphogenesis
GO:0060056	mammary gland involution
GO:0030336	negative regulation of cell migration
GO:0043569	negative regulation of insulin-like growth factor receptor signaling pathway
GO:0045668	negative regulation of osteoblast differentiation
GO:0014912	negative regulation of smooth muscle cell migration
GO:0048662	negative regulation of smooth muscle cell proliferation
GO:0017148	negative regulation of translation
GO:0001649	osteoblast differentiation
GO:0043568	positive regulation of insulin-like growth factor receptor signaling pathway
GO:0051897	positive regulation of protein kinase B signaling cascade
GO:0001558	regulation of cell growth
GO:0010906	regulation of glucose metabolic process
GO:0007165	signal transduction
GO:0048630	skeletal muscle tissue growth
GO:0051146	striated muscle cell differentiation

Cellular Component

GO:0005576	extracellular region
GO:0016942	insulin-like growth factor binding protein complex

Molecular Function

GO:0001968	fibronectin binding
GO:0031994	insulin-like growth factor I binding
GO:0005515	protein binding

insulin-like growth factor binding protein 5

Synonym

Expression Pattern

Choropleth map on BodyParts3D

Classification in 40 Organs

Gene Information

IDs

Orthologous Gene

Chromosomal Region

Gene Family (Interpro ID)

Link to Pubmed (Pubmed ID)

Gene Ontology (GO ID)

Biological Process

Cellular Component

Molecular Function