amyloid beta (A4) precursor protein

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Synonym

ABPP, Protease nexin-II, Amyloid beta A4 protein precursor, PN-II, AD1, CVAP, Alzheimer disease amyloid protein, PN2, APP, ABETA, Amyloid precursor protein, CTFgamma, Cerebral vascular amyloid peptide, PreA4, AAA, APPI

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:42.70 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:368.10 spine:- retina:237.30 eye:23.50 artery/aorta:30 vein:- lymphnode:- peripheral blood:- spleen:- thymus:- bone marrow:19.70 adipose:40.30 bone:12.80 skin:91.20
GeneChip cerebrum:9.13 cerebellum:8.41 brain stem:8.91 corpus callosum/glia:8.96 pineal gland:- peripheral nerve:9.64 spine:8.77 retina:- eye:- artery/aorta:8.74 vein:8.35 lymphnode:7.34 peripheral blood:- spleen:7.71 thymus:6.72 bone marrow:7.69 adipose:8.10 bone:- skin:8.01
CAGE cerebrum:6.56 cerebellum:- brain stem:6.61 corpus callosum/glia:6.76 pineal gland:6.09 peripheral nerve:- spine:6.22 retina:- eye:- artery/aorta:6.07 vein:5.60 lymphnode:4.99 peripheral blood:- spleen:5.44 thymus:4.75 bone marrow:- adipose:5.82 bone:- skin:-
RNA-seq cerebrum:2.25 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:3.99 peripheral blood:- spleen:- thymus:- bone marrow:- adipose:2.53 bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:45.60 placenta:25.50 prostate:90.10 ovary:111.80 testis:26 heart:127.70 muscle:20.10 esophagus:- stomach:- intestine:- colon:25.40     liver/hepato:21.10        lung:53.80    bladder:- kidney:- pituitary:- thyroid/parathyroid:163.70 adrenal gland:101.60 pancreas:115.60 breast:74.30 salivary:-
GeneChip uterus:8.66 placenta:7.76 prostate:8.82 ovary:8.89 testis:7.94 heart:8.79 muscle:6.14 esophagus:7.39 stomach:9.05 intestine:8.70 colon:9.04 liver/hepato:7.93 lung:8 bladder:- kidney:9.75 pituitary:8.01 thyroid/parathyroid:9.73 adrenal gland:8.32 pancreas:8.73 breast:9.02 salivary:7.76
CAGE uterus:5.84 placenta:5.96 prostate:5.91 ovary:5.84 testis:5.86 heart:5.92 muscle:4.66 esophagus:5.54 stomach:- intestine:5.55 colon:5.79     liver/hepato:5.71    lung:5.72 bladder:6.03 kidney:6.65 pituitary:5.82 thyroid/parathyroid:6.42 adrenal gland:- pancreas:5.76 breast:5.75 salivary:5.65
RNA-seq uterus:- placenta:- prostate:5.68 ovary:6.39 testis:5.68 heart:0.02 muscle:2.36 esophagus:- stomach:- intestine:- colon:5.68     liver/hepato:4.49        lung:4.57    bladder:- kidney:6.01 pituitary:- thyroid/parathyroid:5.72 adrenal gland:5.80 pancreas:- breast:4.49 salivary:-

IDs

Refseq ID NM_001136130
Gene ID 351
Unigene ID Hs.434980
Probe set ID 214953_s_at  [HG-U133_Plus_2]
Ensembl ID ENSG00000142192
GTEx ID ENSG00000142192

Orthologous Gene

Mouse[4]  NM_001198823, NM_001198824, NM_001198825, NM_001198826, NM_007471
Rat [0]  

Chromosomal Region

Gene Family (Interpro ID)

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Link to Pubmed  (Pubmed ID)

1302033
1303239
1303244
1303275
1307241
1353447
1363811
1415269
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Gene Ontology  (GO ID)

Biological Process

GO:0008344  adult locomotory behavior
GO:0008088  axon cargo transport
GO:0016199  axon midline choice point recognition
GO:0007409  axonogenesis
GO:0007596  blood coagulation
GO:0007155  cell adhesion
GO:0006878  cellular copper ion homeostasis
GO:0008203  cholesterol metabolic process
GO:0048669  collateral sprouting in the absence of injury
GO:0016358  dendrite development
GO:0006897  endocytosis
GO:0030198  extracellular matrix organization
GO:0030900  forebrain development
GO:0000085  G2 phase of mitotic cell cycle
GO:0006917  induction of apoptosis
GO:0045087  innate immune response
GO:0035235  ionotropic glutamate receptor signaling pathway
GO:0007626  locomotory behavior
GO:0007617  mating behavior
GO:0006378  mRNA polyadenylation
GO:0045665  negative regulation of neuron differentiation
GO:0050885  neuromuscular process controlling balance
GO:0051402  neuron apoptosis
GO:0031175  neuron projection development
GO:0016322  neuron remodeling
GO:0007219  Notch signaling pathway
GO:0030168  platelet activation
GO:0002576  platelet degranulation
GO:0010971  positive regulation of G2/M transition of mitotic cell cycle
GO:0045931  positive regulation of mitotic cell cycle
GO:0045944  positive regulation of transcription from RNA polymerase II promoter
GO:0006468  protein amino acid phosphorylation
GO:0007176  regulation of epidermal growth factor receptor activity
GO:0040014  regulation of multicellular organism growth
GO:0043393  regulation of protein binding
GO:0050803  regulation of synapse structure and activity
GO:0006417  regulation of translation
GO:0006979  response to oxidative stress
GO:0051563  smooth endoplasmic reticulum calcium ion homeostasis
GO:0001967  suckling behavior
GO:0051124  synaptic growth at neuromuscular junction
GO:0008542  visual learning

Cellular Component

GO:0045177  apical part of cell
GO:0030424  axon
GO:0009986  cell surface
GO:0035253  ciliary rootlet
GO:0005905  coated pit
GO:0005737  cytoplasm
GO:0005829  cytosol
GO:0043198  dendritic shaft
GO:0043197  dendritic spine
GO:0005576  extracellular region
GO:0005794  Golgi apparatus
GO:0016021  integral to membrane
GO:0005887  integral to plasma membrane
GO:0043231  intracellular membrane-bounded organelle
GO:0031594  neuromuscular junction
GO:0048471  perinuclear region of cytoplasm
GO:0005886  plasma membrane
GO:0031093  platelet alpha granule lumen
GO:0051233  spindle midzone
GO:0045202  synapse

Molecular Function

GO:0033130  acetylcholine receptor binding
GO:0003677  DNA binding
GO:0070851  growth factor receptor binding
GO:0008201  heparin binding
GO:0042802  identical protein binding
GO:0016504  peptidase activator activity
GO:0005515  protein binding
GO:0051425  PTB domain binding
GO:0005102  receptor binding
GO:0004867  serine-type endopeptidase inhibitor activity
GO:0046914  transition metal ion binding