insulin

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Synonym

Insulin precursor, INS, insulin

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST nodata
GeneChip cerebrum:4.19 cerebellum:4.17 brain stem:4.23 corpus callosum/glia:4.07 pineal gland:- peripheral nerve:3.91 spine:3.91 retina:- eye:- artery/aorta:4.12 vein:4.08 lymphnode:4.19 peripheral blood:- spleen:4.20 thymus:3.84 bone marrow:4.20 adipose:4.20 bone:- skin:4.33
CAGE nodata
RNA-seq cerebrum:0.10 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:0 peripheral blood:- spleen:- thymus:- bone marrow:- adipose:0 bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST nodata
GeneChip uterus:3.94 placenta:3.96 prostate:3.72 ovary:4.06 testis:4.01 heart:4.54 muscle:4.51 esophagus:4.15 stomach:4.07 intestine:7.57 colon:4.26 liver/hepato:4.04 lung:3.99 bladder:- kidney:4.10 pituitary:4.02 thyroid/parathyroid:3.99 adrenal gland:4.50 pancreas:12.80 breast:3.95 salivary:4.26
CAGE nodata
RNA-seq uterus:- placenta:- prostate:0.10 ovary:0 testis:0 heart:0 muscle:0 esophagus:- stomach:- intestine:- colon:0     liver/hepato:0        lung:0    bladder:- kidney:0 pituitary:- thyroid/parathyroid:0 adrenal gland:0 pancreas:- breast:0 salivary:-

IDs

Refseq ID NM_000207
Gene ID 3630
Unigene ID -
Probe set ID 206598_at  [HG-U133_Plus_2]
Ensembl ID ENSG00000254647
GTEx ID ENSG00000254647

Orthologous Gene

Mouse[2]  NM_001185083, NM_001185084, NM_008387, NM_008386
Rat[1]  NM_019129, NM_019130, NM_008387, NM_008386

Chromosomal Region

Gene Family (Interpro ID)

Link to Pubmed  (Pubmed ID)

195962
381941
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24778449

Gene Ontology  (GO ID)

Biological Process

GO:0032148  activation of protein kinase B activity
GO:0006953  acute-phase response
GO:0046631  alpha-beta T cell activation
GO:0007267  cell-cell signaling
GO:0044267  cellular protein metabolic process
GO:0031018  endocrine pancreas development
GO:0006112  energy reserve metabolic process
GO:0055089  fatty acid homeostasis
GO:0007186  G-protein coupled receptor protein signaling pathway
GO:0042593  glucose homeostasis
GO:0006006  glucose metabolic process
GO:0015758  glucose transport
GO:0008286  insulin receptor signaling pathway
GO:0000165  MAPKKK cascade
GO:0002674  negative regulation of acute inflammatory response
GO:0045922  negative regulation of fatty acid metabolic process
GO:0045721  negative regulation of gluconeogenesis
GO:0045818  negative regulation of glycogen catabolic process
GO:0050995  negative regulation of lipid catabolic process
GO:0033861  negative regulation of NAD(P)H oxidase activity
GO:0042177  negative regulation of protein catabolic process
GO:0032460  negative regulation of protein oligomerization
GO:0050709  negative regulation of protein secretion
GO:0045861  negative regulation of proteolysis
GO:0060266  negative regulation of respiratory burst during acute inflammatory response
GO:0045908  negative regulation of vasodilation
GO:0045597  positive regulation of cell differentiation
GO:0030307  positive regulation of cell growth
GO:0030335  positive regulation of cell migration
GO:0008284  positive regulation of cell proliferation
GO:0032270  positive regulation of cellular protein metabolic process
GO:0050715  positive regulation of cytokine secretion
GO:0045740  positive regulation of DNA replication
GO:0046326  positive regulation of glucose import
GO:0045725  positive regulation of glycogen biosynthetic process
GO:0045821  positive regulation of glycolysis
GO:0046628  positive regulation of insulin receptor signaling pathway
GO:0046889  positive regulation of lipid biosynthetic process
GO:0043410  positive regulation of MAPKKK cascade
GO:0045840  positive regulation of mitosis
GO:0051092  positive regulation of NF-kappaB transcription factor activity
GO:0045429  positive regulation of nitric oxide biosynthetic process
GO:0051000  positive regulation of nitric-oxide synthase activity
GO:0050731  positive regulation of peptidyl-tyrosine phosphorylation
GO:0014068  positive regulation of phosphoinositide 3-kinase cascade
GO:0031954  positive regulation of protein amino acid autophosphorylation
GO:0051897  positive regulation of protein kinase B signaling cascade
GO:0060267  positive regulation of respiratory burst
GO:0045909  positive regulation of vasodilation
GO:0006521  regulation of cellular amino acid metabolic process
GO:0050796  regulation of insulin secretion
GO:0032880  regulation of protein localization
GO:0050708  regulation of protein secretion
GO:0006355  regulation of transcription, DNA-dependent
GO:0022898  regulation of transmembrane transporter activity
GO:0042060  wound healing

Cellular Component

GO:0005788  endoplasmic reticulum lumen
GO:0031904  endosome lumen
GO:0005576  extracellular region
GO:0005615  extracellular space
GO:0005796  Golgi lumen
GO:0034774  secretory granule lumen

Molecular Function

GO:0005179  hormone activity
GO:0005158  insulin receptor binding
GO:0005159  insulin-like growth factor receptor binding
GO:0002020  protease binding
GO:0005515  protein binding