interferon stimulated exonuclease gene 20kDa

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Synonym

interferon stimulated gene (20kD), Estrogen-regulated transcript 45 protein, interferon stimulated exonuclease gene 20kDa, Interferon-stimulated gene 20 kDa protein, ISG20, HEM45, CD25

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:1.20 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:30.70 spine:- retina:- eye:41.10 artery/aorta:- vein:- lymphnode:111.20 peripheral blood:36.40 spleen:37.80 thymus:25.80 bone marrow:19.70 adipose:- bone:- skin:-
GeneChip cerebrum:5.06 cerebellum:4.73 brain stem:5.10 corpus callosum/glia:5.23 pineal gland:- peripheral nerve:5.59 spine:4.99 retina:- eye:- artery/aorta:6.08 vein:5.61 lymphnode:7.69 peripheral blood:- spleen:7.91 thymus:7.72 bone marrow:7.06 adipose:6.06 bone:- skin:6.09
CAGE cerebrum:1.24 cerebellum:- brain stem:1.63 corpus callosum/glia:1.39 pineal gland:1.31 peripheral nerve:- spine:1.48 retina:- eye:- artery/aorta:2.12 vein:4.08 lymphnode:4.22 peripheral blood:- spleen:4.47 thymus:3.86 bone marrow:- adipose:2.73 bone:- skin:-
RNA-seq cerebrum:1.49 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:5.83 peripheral blood:- spleen:- thymus:- bone marrow:- adipose:5.29 bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:18.20 placenta:10.90 prostate:22.50 ovary:- testis:4.30 heart:12.80 muscle:- esophagus:- stomach:63.70 intestine:- colon:25.40     liver/hepato:10.60        lung:19.60    bladder:- kidney:20.80 pituitary:- thyroid/parathyroid:- adrenal gland:- pancreas:8.90 breast:- salivary:-
GeneChip uterus:5.49 placenta:5.65 prostate:5.76 ovary:5.76 testis:5.32 heart:5.74 muscle:5.03 esophagus:6.31 stomach:6.62 intestine:6.36 colon:6.50 liver/hepato:5.71 lung:7.18 bladder:- kidney:4.99 pituitary:6.17 thyroid/parathyroid:6.41 adrenal gland:5.65 pancreas:5.75 breast:6.09 salivary:5.71
CAGE uterus:1.84 placenta:2.07 prostate:1.55 ovary:2.48 testis:1.04 heart:2.25 muscle:1.97 esophagus:2.83 stomach:- intestine:4.15 colon:3.21     liver/hepato:2.58    lung:3.66 bladder:2.90 kidney:1.66 pituitary:2.51 thyroid/parathyroid:3.12 adrenal gland:- pancreas:2.34 breast:2.64 salivary:2.43
RNA-seq uterus:- placenta:- prostate:2.51 ovary:3.19 testis:2.02 heart:0.93 muscle:1.11 esophagus:- stomach:- intestine:- colon:3.27     liver/hepato:1.84        lung:6.49    bladder:- kidney:1.32 pituitary:- thyroid/parathyroid:3.89 adrenal gland:5.22 pancreas:- breast:2.32 salivary:-

Gene Information

IDs

Refseq ID NM_002201
Gene ID 3669
Unigene ID Hs.459265
Probe set ID 33304_at  [HG-U133_Plus_2]
Ensembl ID ENSG00000172183
GTEx ID ENSG00000172183

Orthologous Gene

Mouse[2]  NM_001113527, NM_020583
Rat[1]  NM_001008510, NM_020583

Chromosomal Region

15q26.1  [89,181,974  -  89,199,714]

Gene Family (Interpro ID)

IPR006055  Exonuclease
IPR013520  Exonuclease, RNase T/DNA polymerase III
IPR012337  Polynucleotidyl transferase, ribonuclease H fold

Link to Pubmed  (Pubmed ID)

9235947
9569007
9605874
11401564
12477932
12539042
12594219
14702039
15489334
15527770
16514659
18278447
21036379
21732829
21963094
22647704
23251661
23830076

Gene Ontology  (GO ID)

Biological Process

GO:0008283  cell proliferation
GO:0019221  cytokine-mediated signaling pathway
GO:0051607  defense response to virus
GO:0000738  DNA catabolic process, exonucleolytic
GO:0045071  negative regulation of viral genome replication
GO:0009615  response to virus
GO:0006401  RNA catabolic process
GO:0006364  rRNA processing
GO:0060337  type I interferon-mediated signaling pathway

Cellular Component

GO:0015030  Cajal body
GO:0005737  cytoplasm
GO:0005730  nucleolus
GO:0005654  nucleoplasm
GO:0005634  nucleus
GO:0016605  PML body

Molecular Function

GO:0000175  3'-5'-exoribonuclease activity
GO:0004527  exonuclease activity
GO:0008859  exoribonuclease II activity
GO:0046872  metal ion binding
GO:0008310  single-stranded DNA specific 3'-5' exodeoxyribonuclease activity
GO:0030619  U1 snRNA binding
GO:0030620  U2 snRNA binding
GO:0034511  U3 snoRNA binding