integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)

jump to detail

Synonym

Integrin beta-3 precursor, ITGB3, GP3A, CD61, GPIIIa, CD61 antigen, Platelet membrane glycoprotein IIIa

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:7.10 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:17.60 artery/aorta:60 vein:- lymphnode:30.30 peripheral blood:18.20 spleen:- thymus:- bone marrow:- adipose:40.30 bone:25.60 skin:52.80
GeneChip cerebrum:3.90 cerebellum:3.78 brain stem:3.89 corpus callosum/glia:3.67 pineal gland:- peripheral nerve:3.76 spine:3.74 retina:- eye:- artery/aorta:4.11 vein:4.16 lymphnode:3.73 peripheral blood:- spleen:3.55 thymus:3.60 bone marrow:3.81 adipose:3.87 bone:- skin:3.71
CAGE cerebrum:0.58 cerebellum:- brain stem:1.01 corpus callosum/glia:0.66 pineal gland:0.72 peripheral nerve:- spine:1.29 retina:- eye:- artery/aorta:3.76 vein:1.29 lymphnode:0.84 peripheral blood:- spleen:2.32 thymus:0.23 bone marrow:- adipose:2.37 bone:- skin:-
RNA-seq cerebrum:0.85 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:1.72 peripheral blood:- spleen:- thymus:- bone marrow:- adipose:3.57 bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:63.80 placenta:94.70 prostate:22.50 ovary:37.30 testis:21.60 heart:12.80 muscle:- esophagus:- stomach:- intestine:- colon:8.50     liver/hepato:21.10        lung:9.80    bladder:- kidney:156 pituitary:- thyroid/parathyroid:- adrenal gland:- pancreas:- breast:55.80 salivary:-
GeneChip uterus:3.82 placenta:4.42 prostate:3.72 ovary:3.84 testis:3.57 heart:4 muscle:4.09 esophagus:3.90 stomach:3.82 intestine:3.96 colon:4.03 liver/hepato:3.88 lung:3.70 bladder:- kidney:4.06 pituitary:4 thyroid/parathyroid:4.46 adrenal gland:3.84 pancreas:4.46 breast:3.65 salivary:3.89
CAGE uterus:1.95 placenta:3.03 prostate:1.97 ovary:1.75 testis:1.27 heart:2.15 muscle:1.14 esophagus:2.04 stomach:- intestine:1.67 colon:2.72     liver/hepato:1.41    lung:1.54 bladder:2.34 kidney:2.75 pituitary:0.76 thyroid/parathyroid:3.25 adrenal gland:- pancreas:0 breast:2.02 salivary:0.62
RNA-seq uterus:- placenta:- prostate:2.97 ovary:1.93 testis:2.17 heart:0.88 muscle:0.82 esophagus:- stomach:- intestine:- colon:2.71     liver/hepato:1.95        lung:3.24    bladder:- kidney:3.20 pituitary:- thyroid/parathyroid:3.74 adrenal gland:1.68 pancreas:- breast:2.18 salivary:-

IDs

Refseq ID NM_000212
Gene ID 3690
Unigene ID Hs.218040
Probe set ID 204625_s_at  [HG-U133_Plus_2]
Ensembl ID ENSG00000178852
GTEx ID ENSG00000178852

Orthologous Gene

Mouse [0]  
Rat [0]  

Chromosomal Region

Gene Family (Interpro ID)

Link to Pubmed  (Pubmed ID)

1371279
1382574
1429573
1430225
1438206
1549507
1602006
1693624
1693626
1694173
1953640
1967954
2001252
2010551
2138612
2145280
2202737
2341395
2345548
2392682
2452834
2454952
2478219
2565345
2787511
3165296
3494014
3607284
3801670
3828395
7505120
7532190
7539135
7592818
7593198
7682219
7690138
7694683
7878622
8093349
8132570
8132607
8198553
8244378
8298129
8387021
8400294
8467233
8631894
8649427
8663236
8757599
8781422
8798654
8831898
8837777
9030514
9169439
9195946
9215749
9256940
9376589
9517988
9684783
9686320
9790984
9916748
10022831
10037797
10233432
10391209
10397733
10429193
10438928
10497223
10605720
10640428
10684262
10747940
10749942
10822899
10835423
10837460
10848816
10896934
10964917
10964931
10982404
11028489
11042121
11053714
11151063
11235724
11238109
11257275
11279932
11331301
11341749
11397354
11447076
11454259
11460491
11470407
11533523
11545752
11546839
11568114
11577104
11583324
11588040
11606749
11683411
11686325
11704375
11714857
11723131
11739968
11776310
11807098
11812069
11812775
11858476
11858493
11864709
11867691
11875117
11877390
11884718
11891802
11897046
11927607
11932255
11934894
11940607
11953315
11959660
11962738
11994301
12008962
12031826
12036875
12038797
12049640
12071877
12073410
12082590
12082592
12083483
12140290
12152649
12152651
12161360
12168086
12198771
12200372
12204115
12209993
12210725
12218055
12237112
12237321
12297512
12353082
12358597
12362250
12364323
12370491
12372433
12372469
12372811
12393510
12399420
12426312
12427871
12460991
12477932
12486108
12499711
12511588
12514663
12518110
12535520
12553378
12578602
12586134
12606711
12609844
12637342
12639965
12645863
12660257
12665801
12668663
12682293
12690117
12690916
12691260
12694355
12714203
12716314
12719784
12720308
12730600
12736272
12738509
12750158
12765524
12771130
12791034
12799374
12807887
12818249
12818251
12826159
12827240
12855229
12871468
12871600
12874388
12899665
12902444
12902636
12911597
12932598
12941045
12952967
12957761
13678940
14499914
14517343
14521607
14524530
14525764
14557872
14593208
14614355
14629479
14634961
14669168
14675395
14681217
14681220
14690453
14691438
14691579
14746139
14963009
14963283
14966135
14987913
14992889
15044441
15045135
15056669
15067009
15076187
15131115
15134555
15147527
15156152
15166241
15166939
15166947
15166949
15178823
15187087
15215180
15219201
15226180
15227729
15299032
15331787
15344881
15355503
15355504
15456946
15466936
15468167
15489334
15509546
15546585
15564935
15565371
15575508
15583747
15590407
15609125
15627799
15634267
15638730
15663601
15676177
15695828
15699036
15701653
15701721
15705408
15730528
15748237
15795319
15817799
15826939
15834425
15834589
15840736
15842360
15847651
15863506
15886806
15890274
15897908
15917997
15921657
15968394
15970922
15976180
15978110
15990752
15998788
16005200
16005629
16035619
16051597
16051604
16091654
16100725
16102042
16105876
16113799
16115959
16133898
16150802
16153930
16157382
16158739
16166568
16195248
16213489
16228296
16248996
16263699
16275649
16307159
16317099
16317580
16322334
16322781
16335952
16339753
16340127
16353042
16357324
16359515
16380674
16385340
16400188
16407244
16412752
16444441
16469512
16504741
16513293
16567932
16573563
16581250
16582881
16634766
16635210
16636497
16675000
16676352
16702043
16716076
16721604
16723352
16724005
16731529
16756721
16790523
16818691
16822941
16831169
16859511
16875034
16877710
16879215
16895913
16905953
16933105
16935858
16969099
17032655
17034033
17074516
17092301
17111197
17127487
17138951
17146626
17158881
17160992
17175151
17192395
17196570
17203213
17203304
17206538
17218263
17220212
17230042
17258347
17264806
17272505
17278970
17290027
17320454
17332246
17334320
17337041
17346829
17357883
17369840
17376438
17406648
17414216
17432927
17439948
17446174
17468108
17482311
17483236
17515951
17538005
17550972
17556058
17559347
17561290
17607710
17615290
17621633
17630485
17635696
17641225
17642204
17644514
17665449
17679464
17681328
17714854
17728329
17763154
17827388
17854909
17855352
17907177
17912026
17928472
17954176
17957566
17959856
18021403
18031296
18035074
18041653
18045240
18045606
18045938
18051367
18056258
18057877
18062611
18064323
18065693
18067652
18084301
18088350
18156175
18160561
18160589
18162078
18174155
18175315
18191725
18200665
18201749
18208809
18211801
18214290
18230083
18237139
18247041
18260892
18310319
18310446
18312855
18316775
18317590
18321071
18331351
18331836
18334487
18343248
18345483
18353318
18353785
18364349
18375753
18383324
18396070
18399841
18405917
18419255
18433460
18441324
18458155
18484951
18503143
18512729
18513389
18516040
18549690
18550570
18573917
18577523
18635536
18638089
18641368
18648521
18657307
18665040
18673340
18674955
18685811
18709641
18712091
18728123
18791937
18796633
18803625
18814143
18821851
18824633
18826388
18832906
18836720
18836731
18841997
18854176
18927433
18927546
18930220
18936436
18974842
18978678
18979363
18989530
19001202
19008959
19017937
19018779
19019827
19037107
19038456
19061491
19071013
19072566
19074851
19104837
19106083
19110485
19117493
19118033
19118218
19123042
19131662
19132198
19141530
19184277
19197137
19205270
19207108
19212436
19212638
19230252
19232685
19234460
19235843
19238444
19245802
19255147
19262211
19263529
19264973
19267251
19279667
19286442
19329429
19334037
19336355
19336370
19336737
19345676
19350519
19350618
19361361
19366731
19368146
19371633
19374152
19388931
19390575
19395327
19461049
19463111
19463119
19469865
19475568
19487690
19515580
19526385
19527712
19527732
19530321
19541645
19546854
19559392
19562259
19570064
19573311
19588468
19604247
19617625
19630800
19633306
19635510
19637098
19654300
19656390
19670701
19691478
19695571
19702628
19704023
19729601
19730003
19740098
19751734
19765213
19778317
19789190
19804783
19805198
19808093
19808644
19815712
19816083
19821948
19824427
19837659
19860767
19863457
19876733
19882657
19888429
19889638
19903699
19906129
19913121
19923980
19933311
19934566
19948007
19956635
19959486
19996122
20002543
20020534
20033473
20048261
20075254
20076847
20078877
20106508
20138334
20149160
20161734
20162297
20181715
20192979
20204402
20230421
20237496
20306691
20308600
20339539
20363746
20369606
20379614
20406466
20425806
20438394
20452482
20458832
20472470
20477989
20485444
20492470
20519501
20532885
20538554
20546203
20554778
20565758
20584077
20592457
20595101
20600001
20615878
20628086
20634891
20638909
20661303
20667040
20673868
20679525
20691446
20702409
20717043
20739287
20739877
20802378
20819594
20826760
20828133
20837477
20846430
20857483
20873239
20929856
20945385
20978323
21034162
21039385
21044892
21054877
21071690
21080081
21091771
21102624
21109038
21122545
21135163
21143381
21156831
21182210
21190668
21241403
21283814
21325030
21344378
21353223
21508388
21529934
21570717
21590707
21622897
21626402
21645227
21645497
21678053
21764795
21813062
21832081
21917754
21935711
21951552
21966982
21978494
22002573
22015616
22015659
22028352
22078565
22094875
22095620
22102273
22116617
22132110
22136613
22171266
22174124
22174684
22190468
22207115
22268819
22308022
22328516
22362758
22407444
22422622
22448399
22452684
22456341
22457811
22461623
22466811
22484027
22528484
22531012
22538781
22581054
22613710
22641344
22669259
22698642
22730538
22879933
22948415
23003125
23022044
23022222
23119061
23125415
23150579
23152803
23161541
23181508
23184042
23197154
23204516
23216754
23234019
23238957
23243278
23243309
23253071
23289212
23300803
23382103
23382691
23384292
23386126
23389628
23451109
23469002
23494007
23519467
23527123
23545624
23571313
23580774
23628433
23640055
23725446
23726972
23744557
23770013
23840404
23845726
23857544
23860687
23867618
23874206
23913837
23929305
23955631
23981581
24021319
24023288
24030382
24037888
24096143
24109241
24136164
24176823
24437179
24437181
24523237
24690239

Gene Ontology  (GO ID)

Biological Process

GO:0032147  activation of protein kinase activity
GO:0060055  angiogenesis involved in wound healing
GO:0007411  axon guidance
GO:0007596  blood coagulation
GO:0007155  cell adhesion
GO:0007160  cell-matrix adhesion
GO:0007044  cell-substrate junction assembly
GO:0030198  extracellular matrix organization
GO:0007229  integrin-mediated signaling pathway
GO:0050900  leukocyte migration
GO:0010888  negative regulation of lipid storage
GO:0032369  negative regulation of lipid transport
GO:0050748  negative regulation of lipoprotein metabolic process
GO:0045715  negative regulation of low-density lipoprotein receptor biosynthetic process
GO:0010745  negative regulation of macrophage derived foam cell differentiation
GO:0030168  platelet activation
GO:0070527  platelet aggregation
GO:0002576  platelet degranulation
GO:0010595  positive regulation of endothelial cell migration
GO:0001938  positive regulation of endothelial cell proliferation
GO:0050731  positive regulation of peptidyl-tyrosine phosphorylation
GO:0001934  positive regulation of protein amino acid phosphorylation
GO:0030949  positive regulation of vascular endothelial growth factor receptor signaling pathway
GO:0006457  protein folding
GO:0045124  regulation of bone resorption
GO:0014909  smooth muscle cell migration
GO:0035295  tube development
GO:0019048  virus-host interaction
GO:0042060  wound healing

Cellular Component

GO:0071062  alphav-beta3 integrin-vitronectin complex
GO:0005925  focal adhesion
GO:0005887  integral to plasma membrane
GO:0008305  integrin complex
GO:0031258  lamellipodium membrane
GO:0042470  melanosome
GO:0005634  nucleus
GO:0005886  plasma membrane
GO:0031092  platelet alpha granule membrane

Molecular Function

GO:0050839  cell adhesion molecule binding
GO:0042802  identical protein binding
GO:0005161  platelet-derived growth factor receptor binding
GO:0005515  protein binding
GO:0003756  protein disulfide isomerase activity
GO:0004872  receptor activity
GO:0043184  vascular endothelial growth factor receptor 2 binding