LIM homeobox 1

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Synonym

Homeobox protein Lim-1, LIM-1, LHX1, LIM/homeobox protein Lhx1, MGC126723, MGC138141, LIM homeobox 1, LIM homeobox protein 1, LIM1

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:2.40 cerebellum:125.90 brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:11.80 artery/aorta:- vein:- lymphnode:- peripheral blood:- spleen:- thymus:- bone marrow:- adipose:- bone:- skin:-
GeneChip cerebrum:4.22 cerebellum:5.80 brain stem:4.59 corpus callosum/glia:4.13 pineal gland:- peripheral nerve:3.87 spine:4.05 retina:- eye:- artery/aorta:4.14 vein:4.51 lymphnode:4.09 peripheral blood:- spleen:3.92 thymus:3.93 bone marrow:4.16 adipose:4.11 bone:- skin:4.20
CAGE cerebrum:0.56 cerebellum:- brain stem:0.78 corpus callosum/glia:0.07 pineal gland:0 peripheral nerve:- spine:1.09 retina:- eye:- artery/aorta:0.18 vein:0 lymphnode:0 peripheral blood:- spleen:0 thymus:0 bone marrow:- adipose:0 bone:- skin:-
RNA-seq cerebrum:0.06 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:0 peripheral blood:- spleen:- thymus:- bone marrow:- adipose:0 bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:18.20 placenta:- prostate:67.60 ovary:- testis:- heart:- muscle:- esophagus:- stomach:- intestine:- colon:8.50     liver/hepato:-        lung:-    bladder:- kidney:104 pituitary:- thyroid/parathyroid:- adrenal gland:- pancreas:- breast:- salivary:-
GeneChip uterus:4.08 placenta:4.11 prostate:3.86 ovary:4.37 testis:3.91 heart:4.19 muscle:4.45 esophagus:4.01 stomach:3.92 intestine:4.20 colon:4.28 liver/hepato:4.12 lung:4.17 bladder:- kidney:5.05 pituitary:3.93 thyroid/parathyroid:3.97 adrenal gland:3.97 pancreas:4.62 breast:3.94 salivary:4.18
CAGE uterus:0.26 placenta:0 prostate:0.33 ovary:0.56 testis:0.19 heart:0 muscle:0 esophagus:0 stomach:- intestine:0 colon:0     liver/hepato:0    lung:0 bladder:0.09 kidney:2.45 pituitary:0 thyroid/parathyroid:0 adrenal gland:- pancreas:0 breast:0 salivary:0
RNA-seq uterus:- placenta:- prostate:0.38 ovary:0.47 testis:0.32 heart:0 muscle:0 esophagus:- stomach:- intestine:- colon:0     liver/hepato:0        lung:0    bladder:- kidney:2.72 pituitary:- thyroid/parathyroid:0 adrenal gland:0 pancreas:- breast:0.02 salivary:-

Gene Information

IDs

Refseq ID NM_005568
Gene ID 3975
Unigene ID Hs.443727
Probe set ID 206230_at  [HG-U133_Plus_2]
Ensembl ID ENSG00000132130
GTEx ID ENSG00000132130

Orthologous Gene

Mouse[2]  NM_008498
Rat [0]  

Chromosomal Region

17q12  [35,294,772  -  35,301,912]

Gene Family (Interpro ID)

IPR001356  Homeobox
IPR009057  Homeodomain-like
IPR012287  Homeodomain-related

Link to Pubmed  (Pubmed ID)

7700351
8954926
9212161
9452425
9890059
10623575
11882901
12438757
12477932
12642491
15489334
16022279
16625196
19615554
19849868
19889212
20797712
21132009
21778788
22217964
22231913
22740494
22875024
23954021

Gene Ontology  (GO ID)

Biological Process

GO:0048646  anatomical structure formation involved in morphogenesis
GO:0009653  anatomical structure morphogenesis
GO:0009948  anterior/posterior axis specification
GO:0009952  anterior/posterior pattern formation
GO:0001658  branching involved in ureteric bud morphogenesis
GO:0007267  cell-cell signaling
GO:0021702  cerebellar Purkinje cell differentiation
GO:0021937  cerebellar Purkinje cell-granule cell precursor cell signaling involved in regulation of granule cell precursor cell proliferation
GO:0021549  cerebellum development
GO:0060067  cervix development
GO:0009953  dorsal/ventral pattern formation
GO:0001705  ectoderm formation
GO:0009880  embryonic pattern specification
GO:0060059  embryonic retina morphogenesis in camera-type eye
GO:0048703  embryonic viscerocranium morphogenesis
GO:0001706  endoderm formation
GO:0060429  epithelium development
GO:0060066  fallopian tube development
GO:0021871  forebrain regionalization
GO:0001702  gastrulation with mouth forming second
GO:0060322  head development
GO:0001822  kidney development
GO:0008045  motor axon guidance
GO:0045892  negative regulation of transcription, DNA-dependent
GO:0007399  nervous system development
GO:0009887  organ morphogenesis
GO:0007389  pattern specification process
GO:0090190  positive regulation of branching involved in ureteric bud morphogenesis
GO:0040019  positive regulation of embryonic development
GO:0045893  positive regulation of transcription, DNA-dependent
GO:0009791  post-embryonic development
GO:0090009  primitive streak formation
GO:0048793  pronephros development
GO:0010468  regulation of gene expression
GO:0010842  retina layer formation
GO:0032525  somite rostral/caudal axis specification
GO:0021527  spinal cord association neuron differentiation
GO:0021537  telencephalon development
GO:0006366  transcription from RNA polymerase II promoter
GO:0001657  ureteric bud development
GO:0001655  urogenital system development
GO:0060065  uterus development
GO:0060068  vagina development
GO:0021517  ventral spinal cord development

Cellular Component

GO:0005634  nucleus
GO:0043234  protein complex

Molecular Function

GO:0043565  sequence-specific DNA binding
GO:0003714  transcription corepressor activity
GO:0003700  transcription factor activity
GO:0008270  zinc ion binding