leukemia inhibitory factor (cholinergic differentiation factor)

Synonym

Leukemia inhibitory factor precursor, LIF, D factor, Emfilermin, CDF, Differentiation-stimulating factor, MLPLI, D-FACTOR, HILDA, Melanoma-derived LPL inhibitor

normal 40 tissues
cell lines, primary cells, adult tissues and fetal tissues (FANTOM5 CAGE)

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain

blood

connective

EST

cerebrum:4.70

cerebellum:-

brain stem:-

corpus callosum/glia:-

pineal gland:-

peripheral nerve:-

spine:-

retina:-

eye:-

artery/aorta:-

vein:-

lymphnode:-

peripheral blood:-

spleen:-

thymus:-

bone marrow:-

adipose:-

bone:-

skin:-

GeneChip

cerebrum:5.75

cerebellum:5.78

brain stem:5.79

corpus callosum/glia:5.76

pineal gland:-

peripheral nerve:5.74

spine:6.12

retina:-

eye:-

artery/aorta:6.52

vein:7.21

lymphnode:6.05

peripheral blood:-

spleen:5.79

thymus:5.47

bone marrow:6.15

adipose:6.26

bone:-

skin:6.04

CAGE

cerebrum:0.52

cerebellum:-

brain stem:0.87

corpus callosum/glia:0.59

pineal gland:0.62

peripheral nerve:-

spine:1.34

retina:-

eye:-

artery/aorta:2.26

vein:0.70

lymphnode:1.12

peripheral blood:-

spleen:0.39

thymus:0.23

bone marrow:-

adipose:1.01

bone:-

skin:-

RNA-seq

cerebrum:0.18

cerebellum:-

brain stem:-

corpus callosum/glia:-

pineal gland:-

peripheral nerve:-

spine:-

retina:-

eye:-

artery/aorta:-

vein:-

lymphnode:0.61

peripheral blood:-

spleen:-

thymus:-

bone marrow:-

adipose:1.08

bone:-

skin:-

reproductive

muscular

alimentary

liver

lung

urinary

endo/exo-crine

EST

uterus:-

placenta:7.30

prostate:11.30

ovary:-

testis:17.30

heart:-

muscle:-

esophagus:-

stomach:-

intestine:-

colon:-

liver/hepato:10.60

lung:24.40

bladder:-

kidney:62.40

pituitary:-

thyroid/parathyroid:-

adrenal gland:-

pancreas:-

breast:-

salivary:-

GeneChip

uterus:6.08

placenta:5.56

prostate:5.96

ovary:5.99

testis:5.44

heart:6.01

muscle:6.23

esophagus:5.90

stomach:6.13

intestine:6.25

colon:6.51

liver/hepato:6.04

lung:7.09

bladder:-

kidney:5.82

pituitary:6.07

thyroid/parathyroid:5.90

adrenal gland:5.96

pancreas:6.17

breast:6.33

salivary:5.60

CAGE

uterus:0.99

placenta:0.43

prostate:1.11

ovary:1.64

testis:0.41

heart:1.91

muscle:0.33

esophagus:0.57

stomach:-

intestine:0.80

colon:1.06

liver/hepato:0.26

lung:1.93

bladder:2.20

kidney:0.74

pituitary:0.40

thyroid/parathyroid:0.28

adrenal gland:-

pancreas:0

breast:0.90

salivary:0.62

RNA-seq

uterus:-

placenta:-

prostate:0.66

ovary:1.22

testis:0.35

heart:0.32

muscle:0

esophagus:-

stomach:-

intestine:-

colon:0.56

liver/hepato:0.11

lung:2.50

bladder:-

kidney:0.55

pituitary:-

thyroid/parathyroid:0.66

adrenal gland:0.76

pancreas:-

breast:0.76

salivary:-

IDs

Refseq ID	NM_002309
Gene ID	3976
Unigene ID	Hs.22500
Probe set ID	205266_at [HG-U133_Plus_2]
Ensembl ID	ENSG00000128342
GTEx ID	ENSG00000128342

Orthologous Gene

Mouse[6]	NM_001039537, NM_008501
Rat [0]

Chromosomal Region

22q12.2 [30,636,436 - 30,642,840]

Search genes near this gene
- Between -5kb and +5kb
- Between -10kb and +10kb

Gene Family (Interpro ID)

IPR009079	Four-helical cytokine-like, core
IPR003624	Leukemia inhibitory factor
IPR001581	Leukemia inhibitory factor /oncostatin

Gene Ontology (GO ID)

Biological Process

GO:0001974	blood vessel remodeling
GO:0046697	decidualization
GO:0007566	embryo implantation
GO:0006955	immune response
GO:0048861	leukemia inhibitory factor signaling pathway
GO:0048286	lung alveolus development
GO:0060463	lung lobe morphogenesis
GO:0060426	lung vasculature development
GO:0007275	multicellular organismal development
GO:0048644	muscle organ morphogenesis
GO:0008285	negative regulation of cell proliferation
GO:0070373	negative regulation of ERK1 and ERK2 cascade
GO:0046888	negative regulation of hormone secretion
GO:0045835	negative regulation of meiosis
GO:0048666	neuron development
GO:0048711	positive regulation of astrocyte differentiation
GO:0008284	positive regulation of cell proliferation
GO:0045651	positive regulation of macrophage differentiation
GO:0043410	positive regulation of MAPKKK cascade
GO:0033138	positive regulation of peptidyl-serine phosphorylation
GO:0033141	positive regulation of peptidyl-serine phosphorylation of STAT protein
GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0042511	positive regulation of tyrosine phosphorylation of Stat1 protein
GO:0042517	positive regulation of tyrosine phosphorylation of Stat3 protein
GO:0060708	spongiotrophoblast differentiation
GO:0019827	stem cell maintenance
GO:0060707	trophoblast giant cell differentiation
GO:0042503	tyrosine phosphorylation of Stat3 protein

Cellular Component

GO:0005737	cytoplasm
GO:0005615	extracellular space

Molecular Function

GO:0005125	cytokine activity
GO:0008083	growth factor activity
GO:0005146	leukemia inhibitory factor receptor binding
GO:0005102	receptor binding

leukemia inhibitory factor (cholinergic differentiation factor)

Synonym

Expression Pattern

Choropleth map on BodyParts3D

Classification in 40 Organs

Gene Information

IDs

Orthologous Gene

Chromosomal Region

Gene Family (Interpro ID)

Link to Pubmed (Pubmed ID)

Gene Ontology (GO ID)

Biological Process

Cellular Component

Molecular Function