SMAD family member 7

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Synonym

SMAD, mothers against DPP homolog 7 (Drosophila), SMAD 7, MADH8, Mothers against DPP homolog 7, SMAD-7, SMAD7, MADH7, hSMAD7, Smad7, Smad-7, FLJ16482, Mothers against decapentaplegic homolog 7, Smad 7

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:17.80 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:61.30 spine:112.30 retina:- eye:47 artery/aorta:119.90 vein:- lymphnode:10.10 peripheral blood:36.40 spleen:- thymus:- bone marrow:19.70 adipose:- bone:38.40 skin:9.60
GeneChip cerebrum:5.82 cerebellum:6.46 brain stem:5.62 corpus callosum/glia:6.39 pineal gland:- peripheral nerve:5.56 spine:6.42 retina:- eye:- artery/aorta:7.56 vein:7.95 lymphnode:5.88 peripheral blood:- spleen:6.18 thymus:4.57 bone marrow:5.15 adipose:6.31 bone:- skin:5.75
CAGE cerebrum:0.41 cerebellum:- brain stem:0.49 corpus callosum/glia:0.47 pineal gland:0.36 peripheral nerve:- spine:0.48 retina:- eye:- artery/aorta:1.65 vein:0.59 lymphnode:0.17 peripheral blood:- spleen:0.25 thymus:0.33 bone marrow:- adipose:0.63 bone:- skin:-
RNA-seq cerebrum:0.80 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:2.08 peripheral blood:- spleen:- thymus:- bone marrow:- adipose:2.22 bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:18.20 placenta:18.20 prostate:- ovary:- testis:- heart:89.40 muscle:- esophagus:- stomach:- intestine:- colon:8.50     liver/hepato:-        lung:4.90    bladder:- kidney:31.20 pituitary:- thyroid/parathyroid:- adrenal gland:- pancreas:35.60 breast:9.30 salivary:-
GeneChip uterus:6.44 placenta:7.40 prostate:6.48 ovary:6.07 testis:4 heart:6.90 muscle:5.73 esophagus:5.51 stomach:6.50 intestine:6.38 colon:6.61 liver/hepato:6.15 lung:7.37 bladder:- kidney:6.76 pituitary:5.75 thyroid/parathyroid:6.91 adrenal gland:6.18 pancreas:4.38 breast:6.03 salivary:5.53
CAGE uterus:0.60 placenta:0.30 prostate:1.00 ovary:0.26 testis:0.21 heart:0.69 muscle:0.24 esophagus:0.33 stomach:- intestine:1.35 colon:1.39     liver/hepato:0.55    lung:1.31 bladder:0.73 kidney:0.82 pituitary:0.42 thyroid/parathyroid:0.95 adrenal gland:- pancreas:0.94 breast:1.16 salivary:0.36
RNA-seq uterus:- placenta:- prostate:1.74 ovary:1.04 testis:0.56 heart:1.45 muscle:0.01 esophagus:- stomach:- intestine:- colon:1.09     liver/hepato:0.00        lung:0.66    bladder:- kidney:1.47 pituitary:- thyroid/parathyroid:0.80 adrenal gland:0.97 pancreas:- breast:1.03 salivary:-

Gene Information

IDs

Refseq ID NM_005904
Gene ID 4092
Unigene ID Hs.465087
Probe set ID 204790_at  [HG-U133_Plus_2]
Ensembl ID ENSG00000101665
GTEx ID ENSG00000101665

Orthologous Gene

Mouse[1]  NM_001042660
Rat[1]  NM_030858

Chromosomal Region

18q21.1  [46,446,223  -  46,477,081]

Gene Family (Interpro ID)

IPR003619  MAD homology 1, Dwarfin-type
IPR013019  MAD homology, MH1
IPR001132  SMAD domain, Dwarfin-type
IPR017855  SMAD domain-like
IPR008984  SMAD/FHA domain

Link to Pubmed  (Pubmed ID)

9215638
9256479
9335507
9436979
9730599
9759503
9786930
9892009
10647776
10708948
10708949
10757800
10823886
10887185
11163210
11278251
11483516
11737269
11904440
12023024
12118366
12151385
12202987
12397035
12407115
12408818
12477932
12519765
12589052
12650946
12815042
12947087
12952364
14557482
14657019
14718519
14722617
14728725
14988821
14993265
15023526
15033458
15033661
15075243
15128733
15132952
15148321
15221015
15231748
15342556
15359284
15489334
15496141
15498852
15529348
15579469
15621726
15632190
15661223
15684397
15708859
15736400
15761153
15788410
15811425
15811853
15817471
15820682
15831498
15831516
15877825
15922743
15946939
16007121
16027725
16061177
16179804
16187293
16260615
16285943
16288847
16344560
16362038
16442497
16601693
16641086
16690609
16714330
16718778
16720724
17009056
17098745
17172861
17230494
17314099
17332363
17377371
17384642
17438144
17510063
17657819
17704440
17928287
17931948
17934461
18029348
18041647
18163503
18231913
18372901
18372905
18445023
18448069
18593713
18616749
18683731
18684712
18762808
18952608
19018011
19032343
19192480
19288000
19341727
19352540
19357349
19395656
19505925
19562778
19624886
19693466
19730683
19758997
19843678
19861282
19875456
19878580
19885573
20040761
20124488
20165854
20200978
20354004
20416076
20437058
20501757
20514018
20530476
20551054
20638935
20648012
20658468
20659471
20663871
20734064
20738806
20819778
20863724
20937913
21054221
21071539
21075068
21221812
21258410
21445336
21761138
21791611
21795712
21883230
21900845
21910156
21931165
22028324
22033246
22229264
22232431
22286770
22344298
22457752
22496417
22624557
22641218
22751114
22773947
22841502
22876112
22921829
23027871
23034881
23049692
23064961
23104301
23128233
23244128
23255602
23258148
23266556
23390194
23435373
23455153
23472153
23530056
23560096
23567938
23625826
23747528
23781096
23804438
23949881
23959799
23973329
23998914
24039762
24066093
24090133
24259667
24343358
24659668
24700460
24850914

Gene Ontology  (GO ID)

Biological Process

GO:0034333  adherens junction assembly
GO:0048844  artery morphogenesis
GO:0030509  BMP signaling pathway
GO:0034629  cellular protein complex localization
GO:0010467  gene expression
GO:0030514  negative regulation of BMP signaling pathway
GO:0030336  negative regulation of cell migration
GO:0010719  negative regulation of epithelial to mesenchymal transition
GO:0060394  negative regulation of pathway-restricted SMAD protein phosphorylation
GO:0033137  negative regulation of peptidyl-serine phosphorylation
GO:0010801  negative regulation of peptidyl-threonine phosphorylation
GO:0031397  negative regulation of protein ubiquitination
GO:0010944  negative regulation of transcription by competitive promoter binding
GO:0043433  negative regulation of transcription factor activity
GO:0000122  negative regulation of transcription from RNA polymerase II promoter
GO:0030512  negative regulation of transforming growth factor beta receptor signaling pathway
GO:0051444  negative regulation of ubiquitin-protein ligase activity
GO:0060389  pathway-restricted SMAD protein phosphorylation
GO:0022409  positive regulation of cell-cell adhesion
GO:0032436  positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0031398  positive regulation of protein ubiquitination
GO:0045944  positive regulation of transcription from RNA polymerase II promoter
GO:0050821  protein stabilization
GO:0032925  regulation of activin receptor signaling pathway
GO:0055117  regulation of cardiac muscle contraction
GO:0017015  regulation of transforming growth factor beta receptor signaling pathway
GO:0060373  regulation of ventricular cardiomyocyte membrane depolarization
GO:0034616  response to laminar fluid shear stress
GO:0006367  transcription initiation from RNA polymerase II promoter
GO:0006351  transcription, DNA-dependent
GO:0007179  transforming growth factor beta receptor signaling pathway
GO:0001657  ureteric bud development
GO:0055010  ventricular cardiac muscle tissue morphogenesis
GO:0060412  ventricular septum morphogenesis

Cellular Component

GO:0016342  catenin complex
GO:0005913  cell-cell adherens junction
GO:0005737  cytoplasm
GO:0005829  cytosol
GO:0005654  nucleoplasm
GO:0005634  nucleus
GO:0005886  plasma membrane
GO:0005667  transcription factor complex

Molecular Function

GO:0048185  activin binding
GO:0008013  beta-catenin binding
GO:0005518  collagen binding
GO:0044212  DNA regulatory region binding
GO:0070411  I-SMAD binding
GO:0046872  metal ion binding
GO:0005515  protein binding
GO:0003700  transcription factor activity
GO:0030617  transforming growth factor beta receptor, inhibitory cytoplasmic mediator activity
GO:0034713  type I transforming growth factor beta receptor binding
GO:0031625  ubiquitin protein ligase binding