neurofibromin 1

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Synonym

VRNF, WSS, Neurofibromin, NFNS, DKFZp686J1293, NF1, Neurofibromatosis-related protein NF-1

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:51 cerebellum:12.60 brain stem:- corpus callosum/glia:29.20 pineal gland:148.30 peripheral nerve:- spine:- retina:- eye:117.50 artery/aorta:- vein:- lymphnode:70.80 peripheral blood:18.20 spleen:- thymus:25.80 bone marrow:- adipose:- bone:- skin:62.40
GeneChip cerebrum:5.16 cerebellum:5.04 brain stem:5.11 corpus callosum/glia:5.30 pineal gland:- peripheral nerve:5.23 spine:5.21 retina:- eye:- artery/aorta:5.18 vein:5.10 lymphnode:4.95 peripheral blood:- spleen:5.01 thymus:4.96 bone marrow:4.89 adipose:5.12 bone:- skin:4.81
CAGE cerebrum:4.63 cerebellum:- brain stem:4.51 corpus callosum/glia:4.38 pineal gland:4.92 peripheral nerve:- spine:4.55 retina:- eye:- artery/aorta:4.06 vein:3.95 lymphnode:3.22 peripheral blood:- spleen:3.98 thymus:3.85 bone marrow:- adipose:3.98 bone:- skin:-
RNA-seq cerebrum:1.34 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:2.67 peripheral blood:- spleen:- thymus:- bone marrow:- adipose:2.81 bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:18.20 placenta:18.20 prostate:11.30 ovary:- testis:21.60 heart:38.30 muscle:- esophagus:- stomach:- intestine:- colon:17     liver/hepato:-        lung:48.90    bladder:- kidney:31.20 pituitary:- thyroid/parathyroid:- adrenal gland:- pancreas:88.90 breast:- salivary:-
GeneChip uterus:5.10 placenta:5.15 prostate:4.91 ovary:5.11 testis:5.01 heart:5.10 muscle:4.96 esophagus:4.81 stomach:5.16 intestine:4.87 colon:5.20 liver/hepato:4.91 lung:5.20 bladder:- kidney:4.99 pituitary:5.11 thyroid/parathyroid:5.09 adrenal gland:5.17 pancreas:5.05 breast:5.12 salivary:4.96
CAGE uterus:4.15 placenta:4.13 prostate:4.05 ovary:3.92 testis:4.37 heart:4.17 muscle:3.95 esophagus:3.75 stomach:- intestine:4.07 colon:3.82     liver/hepato:3.81    lung:4.10 bladder:4.12 kidney:4.09 pituitary:4.58 thyroid/parathyroid:4.00 adrenal gland:- pancreas:3.65 breast:4.10 salivary:3.88
RNA-seq uterus:- placenta:- prostate:2.67 ovary:2.47 testis:2.25 heart:2.66 muscle:0.90 esophagus:- stomach:- intestine:- colon:2.75     liver/hepato:0.00        lung:2.05    bladder:- kidney:0.75 pituitary:- thyroid/parathyroid:2.29 adrenal gland:1.83 pancreas:- breast:2.05 salivary:-

IDs

Refseq ID NM_001042492
Gene ID 4763
Unigene ID Hs.113577
Probe set ID 211914_x_at  [HG-U133_Plus_2]
Ensembl ID ENSG00000196712
GTEx ID ENSG00000196712

Orthologous Gene

Mouse[2]  NM_010897
Rat [0]  

Chromosomal Region

Gene Family (Interpro ID)

Link to Pubmed  (Pubmed ID)

1302608
1329097
1339276
1457041
1550670
1568247
1570015
1662505
1715669
1719426
1745350
1757093
1783401
1923522
1937470
2114220
2116237
2121370
2121371
2125369
2134734
2491776
7519874
7570581
7633431
7633452
7649559
7686513
7774960
7874161
7903661
7904209
7959746
7981679
7981724
8069310
8081387
8176268
8317503
8417346
8544190
8602361
8619474
8628317
8664912
8807336
8825042
8825634
8834249
8836031
8931693
9002664
9003501
9101300
9110174
9150739
9298829
9300663
9529361
9639526
9668168
9706718
10220149
10336779
10553997
10607834
10625171
10712197
10721668
10862698
11140831
11258625
11356864
11704931
11727199
11727265
11735023
11748857
11751683
11754043
11857752
11896214
11896613
11934389
12073021
12077339
12095621
12152785
12191989
12199909
12368469
12387455
12438263
12477932
12483293
12522551
12552569
12566521
12660952
12707950
12730209
12746402
12807981
12872266
12963615
13679444
13680360
14647436
14722914
14988005
15096131
15146197
15146469
15233998
15302935
15342556
15371411
15389774
15520408
15523626
15523642
15583390
15627836
15735964
15767669
15944227
15988004
15999204
16005615
16081245
16083285
16116616
16138909
16169856
16199547
16344560
16374483
16380919
16405917
16467218
16470740
16479075
16565220
16644864
16648142
16741618
16773574
16813595
16830335
16835260
16835897
16908010
16914719
16944271
16944272
17036045
17053831
17096025
17102080
17160901
17187824
17200120
17216419
17295913
17299016
17353900
17404841
17426081
17514731
17563086
17581973
17668375
17726231
17876295
17880527
17914445
17960768
17999360
18021924
18055911
18086893
18172006
18183042
18212816
18214791
18215124
18218617
18316778
18331998
18407053
18484666
18485440
18503770
18511569
18546366
18592002
18802710
18948576
19041782
19048115
19061981
19120036
19142971
19144660
19215943
19220708
19221814
19238080
19291764
19292874
19351817
19417008
19449407
19601812
19650418
19718661
19773259
19845691
19913121
19940123
19946888
20002172
20006588
20015894
20052761
20082856
20124472
20129251
20160012
20160346
20164853
20301288
20301471
20301612
20358387
20379614
20422842
20428205
20435627
20442305
20503322
20505189
20513137
20543202
20571392
20587590
20602485
20624961
20628086
20655465
20680410
20687928
20725927
20927530
21048031
21089070
21139048
21142935
21157378
21199919
21236316
21244408
21278392
21280148
21283084
21337692
21365283
21478499
21551249
21674567
21728811
21732117
21782795
21890473
21903422
21931722
21963094
22015770
22096509
22105171
22108604
22125493
22190464
22207399
22240541
22241097
22250039
22293200
22294457
22354384
22399775
22412049
22488919
22573716
22581253
22585738
22586326
22700876
22751498
22807134
22837079
22925204
22945628
22962301
22965642
22965773
23000965
23010473
23047742
23077663
23082153
23135915
23145129
23165953
23171796
23222849
23244495
23288408
23292448
23312374
23335975
23407919
23423222
23437333
23460398
23481210
23528211
23583712
23624750
23668869
23906300
23913538
23947441
24218100
24249802
24250222
24255178
24334617
24361808
24370551
24375753

Gene Ontology  (GO ID)

Biological Process

GO:0030036  actin cytoskeleton organization
GO:0030325  adrenal gland development
GO:0048844  artery morphogenesis
GO:0007420  brain development
GO:0048593  camera-type eye morphogenesis
GO:0007154  cell communication
GO:0021987  cerebral cortex development
GO:0050890  cognition
GO:0030199  collagen fibril organization
GO:0030198  extracellular matrix organization
GO:0021897  forebrain astrocyte development
GO:0048853  forebrain morphogenesis
GO:0007507  heart development
GO:0001889  liver development
GO:0000165  MAPKKK cascade
GO:0001656  metanephros development
GO:0022011  myelination in the peripheral nervous system
GO:0016525  negative regulation of angiogenesis
GO:0048712  negative regulation of astrocyte differentiation
GO:0030336  negative regulation of cell migration
GO:0001953  negative regulation of cell-matrix adhesion
GO:0001937  negative regulation of endothelial cell proliferation
GO:0048147  negative regulation of fibroblast proliferation
GO:0043407  negative regulation of MAP kinase activity
GO:0043409  negative regulation of MAPKKK cascade
GO:0007406  negative regulation of neuroblast proliferation
GO:0046929  negative regulation of neurotransmitter secretion
GO:0048715  negative regulation of oligodendrocyte differentiation
GO:0045671  negative regulation of osteoclast differentiation
GO:0006469  negative regulation of protein kinase activity
GO:0035021  negative regulation of Rac protein signal transduction
GO:0046580  negative regulation of Ras protein signal transduction
GO:0042992  negative regulation of transcription factor import into nucleus
GO:0021915  neural tube development
GO:0001649  osteoblast differentiation
GO:0007422  peripheral nervous system development
GO:0014065  phosphoinositide 3-kinase cascade
GO:0043473  pigmentation
GO:0045762  positive regulation of adenylate cyclase activity
GO:0043065  positive regulation of apoptosis
GO:0001938  positive regulation of endothelial cell proliferation
GO:0043525  positive regulation of neuron apoptosis
GO:0032320  positive regulation of Ras GTPase activity
GO:0007265  Ras protein signal transduction
GO:0045765  regulation of angiogenesis
GO:0043535  regulation of blood vessel endothelial cell migration
GO:0045124  regulation of bone resorption
GO:0001952  regulation of cell-matrix adhesion
GO:0045685  regulation of glial cell differentiation
GO:0048169  regulation of long-term neuronal synaptic plasticity
GO:0032318  regulation of Ras GTPase activity
GO:0032228  regulation of synaptic transmission, GABAergic
GO:0001666  response to hypoxia
GO:0014044  Schwann cell development
GO:0007519  skeletal muscle tissue development
GO:0048745  smooth muscle tissue development
GO:0021510  spinal cord development
GO:0048485  sympathetic nervous system development
GO:0008542  visual learning
GO:0042060  wound healing

Cellular Component

GO:0030424  axon
GO:0005737  cytoplasm
GO:0030425  dendrite
GO:0031235  intrinsic to internal side of plasma membrane
GO:0005634  nucleus

Molecular Function

GO:0005515  protein binding
GO:0005099  Ras GTPase activator activity