nardilysin (N-arginine dibasic convertase)

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Synonym

NRD-C, NRD convertase, N-arginine dibasic convertase, hNRD2, hNRD1, Nardilysin precursor, nardilysin (N-arginine dibasic convertase), NRD1

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:179 cerebellum:264.50 brain stem:- corpus callosum/glia:175 pineal gland:445 peripheral nerve:122.70 spine:112.30 retina:118.60 eye:111.70 artery/aorta:89.90 vein:133.30 lymphnode:101.10 peripheral blood:36.40 spleen:189.10 thymus:193.30 bone marrow:236.20 adipose:121 bone:76.80 skin:187.20
GeneChip cerebrum:7.76 cerebellum:7.51 brain stem:7.82 corpus callosum/glia:7.83 pineal gland:- peripheral nerve:7.59 spine:7.53 retina:- eye:- artery/aorta:7.41 vein:7.78 lymphnode:7.77 peripheral blood:- spleen:7.59 thymus:8.15 bone marrow:8.06 adipose:7.67 bone:- skin:7.88
CAGE cerebrum:3.64 cerebellum:- brain stem:3.94 corpus callosum/glia:3.59 pineal gland:4.01 peripheral nerve:- spine:3.74 retina:- eye:- artery/aorta:3.27 vein:3.54 lymphnode:3.60 peripheral blood:- spleen:3.76 thymus:3.92 bone marrow:- adipose:3.95 bone:- skin:-
RNA-seq cerebrum:4.46 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:3.97 peripheral blood:- spleen:- thymus:- bone marrow:- adipose:4.90 bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:209.60 placenta:120.20 prostate:78.90 ovary:223.60 testis:540.80 heart:255.40 muscle:180.80 esophagus:- stomach:191.20 intestine:32.40 colon:59.40     liver/hepato:126.70        lung:288.40    bladder:- kidney:83.20 pituitary:116 thyroid/parathyroid:- adrenal gland:- pancreas:62.20 breast:158 salivary:-
GeneChip uterus:7.60 placenta:8.13 prostate:7.92 ovary:7.89 testis:9.13 heart:7.96 muscle:9.47 esophagus:7.79 stomach:7.46 intestine:7.89 colon:7.35 liver/hepato:7.76 lung:7.88 bladder:- kidney:7.37 pituitary:7.89 thyroid/parathyroid:7.31 adrenal gland:7.64 pancreas:7.83 breast:7.66 salivary:7.38
CAGE uterus:3.64 placenta:3.71 prostate:3.72 ovary:3.63 testis:3.68 heart:4.05 muscle:5.09 esophagus:3.78 stomach:- intestine:3.52 colon:3.51     liver/hepato:4.31    lung:3.61 bladder:3.75 kidney:3.62 pituitary:3.89 thyroid/parathyroid:3.50 adrenal gland:- pancreas:3.57 breast:3.58 salivary:3.29
RNA-seq uterus:- placenta:- prostate:4.37 ovary:4.61 testis:4.76 heart:4.66 muscle:6.77 esophagus:- stomach:- intestine:- colon:4.61     liver/hepato:3.78        lung:3.59    bladder:- kidney:4.12 pituitary:- thyroid/parathyroid:5.18 adrenal gland:4.17 pancreas:- breast:4.58 salivary:-

Gene Information

IDs

Refseq ID NM_001101662
Gene ID 4898
Unigene ID Hs.584782
Probe set ID 208709_s_at  [HG-U133_Plus_2]
Ensembl ID ENSG00000078618
GTEx ID ENSG00000078618

Orthologous Gene

Mouse[2]  NM_146150
Rat [0]  

Chromosomal Region

1p32.3  [52,254,863  -  52,344,477]

Gene Family (Interpro ID)

-

Link to Pubmed  (Pubmed ID)

9479496
9581555
11042131
11432822
11478915
12095415
12463163
12477932
12590613
14702039
15385968
15489334
15544571
16061636
16344560
16710414
16923819
17442499
18355445
18362890
18781797
19118164
19615732
19797269
20877624
21139048
21151101
21703634
21801775
21890473
21906983
21972134
22174317
22294699
22351606
22653443
22863883
22939629
23000965
23219461
23604405
24168165
24816145

Gene Ontology  (GO ID)

Biological Process

GO:0016477  cell migration
GO:0008283  cell proliferation
GO:0007528  neuromuscular junction development
GO:0051044  positive regulation of membrane protein ectodomain proteolysis
GO:0006508  proteolysis
GO:0052548  regulation of endopeptidase activity

Cellular Component

GO:0009986  cell surface
GO:0005829  cytosol

Molecular Function

GO:0048408  epidermal growth factor binding
GO:0046872  metal ion binding
GO:0004222  metalloendopeptidase activity
GO:0005515  protein binding