receptor tyrosine kinase-like orphan receptor 2

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Synonym

BDB, receptor tyrosine kinase-like orphan receptor 2, Neurotrophic tyrosine kinase, receptor-related 2, ROR2, NTRKR2, BDB1

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:- cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:- peripheral blood:- spleen:- thymus:- bone marrow:- adipose:- bone:- skin:-
GeneChip cerebrum:3.39 cerebellum:3.44 brain stem:3.38 corpus callosum/glia:3.49 pineal gland:- peripheral nerve:3.20 spine:3.17 retina:- eye:- artery/aorta:3.48 vein:3.94 lymphnode:3.41 peripheral blood:- spleen:3.58 thymus:3.26 bone marrow:3.38 adipose:3.56 bone:- skin:3.69
CAGE cerebrum:0.47 cerebellum:- brain stem:0.46 corpus callosum/glia:1.68 pineal gland:0.47 peripheral nerve:- spine:0.41 retina:- eye:- artery/aorta:1.68 vein:1.73 lymphnode:1.33 peripheral blood:- spleen:2.05 thymus:1.47 bone marrow:- adipose:1.12 bone:- skin:-
RNA-seq cerebrum:0.27 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:1.21 peripheral blood:- spleen:- thymus:- bone marrow:- adipose:0.52 bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:- placenta:- prostate:- ovary:- testis:- heart:- muscle:- esophagus:- stomach:- intestine:- colon:-     liver/hepato:-        lung:-    bladder:- kidney:- pituitary:- thyroid/parathyroid:- adrenal gland:- pancreas:- breast:- salivary:-
GeneChip uterus:4.91 placenta:3.65 prostate:4.49 ovary:4.38 testis:3.92 heart:3.79 muscle:3.49 esophagus:3.54 stomach:4.36 intestine:3.96 colon:4.27 liver/hepato:3.25 lung:3.59 bladder:- kidney:3.36 pituitary:3.40 thyroid/parathyroid:4.08 adrenal gland:3.91 pancreas:3.54 breast:4.31 salivary:3.29
CAGE uterus:3.79 placenta:2.39 prostate:3.49 ovary:3.40 testis:2.19 heart:1.14 muscle:0.72 esophagus:2.57 stomach:- intestine:2.31 colon:3.30     liver/hepato:0.36    lung:1.83 bladder:3.59 kidney:1.30 pituitary:1.04 thyroid/parathyroid:2.48 adrenal gland:- pancreas:1.59 breast:1.80 salivary:0.62
RNA-seq uterus:- placenta:- prostate:3.75 ovary:3.50 testis:2.92 heart:0.16 muscle:0.08 esophagus:- stomach:- intestine:- colon:3.61     liver/hepato:0.07        lung:1.92    bladder:- kidney:0.92 pituitary:- thyroid/parathyroid:1.98 adrenal gland:0.94 pancreas:- breast:0.77 salivary:-

Gene Information

IDs

Refseq ID NM_004560
Gene ID 4920
Unigene ID Hs.644776
Probe set ID 205578_at  [HG-U133_Plus_2]
Ensembl ID ENSG00000169071
GTEx ID ENSG00000169071

Orthologous Gene

Mouse[1]  NM_013846
Rat[1]  NM_001107339

Chromosomal Region

9q22.31  [94,325,373  -  94,712,444]

Gene Family (Interpro ID)

IPR020067  Frizzled-like domain
IPR000001  Kringle
IPR013806  Kringle-like fold
IPR000719  Protein kinase, catalytic domain
IPR011009  Protein kinase-like domain
IPR002290  Serine/threonine-protein kinase domain
IPR017442  Serine/threonine-protein kinase-like domain
IPR020685  Tyrosine-protein kinase
IPR001245  Tyrosine-protein kinase, catalytic domain
IPR020933  Tyrosine-protein kinase, fibroblast growth factor receptor, conserved region
IPR020763  Tyrosine-protein kinase, receptor ROR
IPR016247  Tyrosine-protein kinase, receptor ROR, subgroup
IPR020635  Tyrosine-protein kinase, subgroup, catalytic domain

Link to Pubmed  (Pubmed ID)

1334494
9973296
10700182
10932186
10932187
10986040
11062486
12011143
12477932
12754255
12815588
12839624
12919145
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15654020
17095577
17101003
17619808
17665217
17668388
17717073
17996904
18215320
18365018
18615587
18703641
18762249
18831060
19135982
19448672
19453261
19461659
19486338
19533773
19561643
19640924
19724895
19802008
19851296
20098747
20185829
20198315
20301418
20591152
20634891
21069266
21139048
21342370
21377971
21693067
21890473
22057548
22128168
22178368
22293903
22294416
22490406
22493546
22688191
22781592
22939624
22988987
22992069
23233346
23238279
23278988
23469623
23893409
23963164
24158497

Gene Ontology  (GO ID)

Biological Process

GO:0001502  cartilage condensation
GO:0030154  cell differentiation
GO:0030538  embryonic genitalia morphogenesis
GO:0042472  inner ear morphogenesis
GO:0007254  JNK cascade
GO:0007275  multicellular organismal development
GO:0008285  negative regulation of cell proliferation
GO:0090090  negative regulation of Wnt receptor signaling pathway through beta-catenin
GO:0030335  positive regulation of cell migration
GO:0045893  positive regulation of transcription, DNA-dependent
GO:0007165  signal transduction
GO:0001756  somitogenesis
GO:0007169  transmembrane receptor protein tyrosine kinase signaling pathway
GO:0007223  Wnt receptor signaling pathway, calcium modulating pathway
GO:0060071  Wnt receptor signaling pathway, planar cell polarity pathway

Cellular Component

GO:0005887  integral to plasma membrane

Molecular Function

GO:0005524  ATP binding
GO:0005109  frizzled binding
GO:0005515  protein binding
GO:0004714  transmembrane receptor protein tyrosine kinase activity
GO:0017147  Wnt-protein binding