paired box 6

Synonym

MGDA, Aniridia type II protein, Paired box protein Pax-6, WAGR, MGC17209, Oculorhombin, D11S812E, AN2, paired box gene 6 (aniridia, keratitis), PAX6

normal 40 tissues
cell lines, primary cells, adult tissues and fetal tissues (FANTOM5 CAGE)

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain

blood

connective

EST

cerebrum:-

cerebellum:-

brain stem:-

corpus callosum/glia:-

pineal gland:-

peripheral nerve:-

spine:-

retina:-

eye:-

artery/aorta:-

vein:-

lymphnode:-

peripheral blood:-

spleen:-

thymus:-

bone marrow:-

adipose:-

bone:-

skin:-

GeneChip

cerebrum:7.30

cerebellum:10.28

brain stem:7.20

corpus callosum/glia:7.98

pineal gland:-

peripheral nerve:5.09

spine:7.90

retina:-

eye:-

artery/aorta:5.38

vein:5.67

lymphnode:4.98

peripheral blood:-

spleen:4.78

thymus:4.97

bone marrow:5.06

adipose:5.27

bone:-

skin:5.71

CAGE

cerebrum:4.09

cerebellum:-

brain stem:3.03

corpus callosum/glia:3.87

pineal gland:4.26

peripheral nerve:-

spine:4.52

retina:-

eye:-

artery/aorta:1.16

vein:0.34

lymphnode:0.30

peripheral blood:-

spleen:0

thymus:0.28

bone marrow:-

adipose:0

bone:-

skin:-

RNA-seq

cerebrum:0.81

cerebellum:-

brain stem:-

corpus callosum/glia:-

pineal gland:-

peripheral nerve:-

spine:-

retina:-

eye:-

artery/aorta:-

vein:-

lymphnode:0.30

peripheral blood:-

spleen:-

thymus:-

bone marrow:-

adipose:0.00

bone:-

skin:-

reproductive

muscular

alimentary

liver

lung

urinary

endo/exo-crine

EST

uterus:-

placenta:-

prostate:-

ovary:-

testis:-

heart:-

muscle:-

esophagus:-

stomach:-

intestine:-

colon:-

liver/hepato:-

lung:-

bladder:-

kidney:-

pituitary:-

thyroid/parathyroid:-

adrenal gland:-

pancreas:-

breast:-

salivary:-

GeneChip

uterus:4.94

placenta:5.28

prostate:4.82

ovary:4.93

testis:5.91

heart:5.47

muscle:5.50

esophagus:5.36

stomach:5.81

intestine:5.82

colon:5.20

liver/hepato:5.45

lung:5.12

bladder:-

kidney:5.25

pituitary:6.80

thyroid/parathyroid:4.84

adrenal gland:5.34

pancreas:6.57

breast:4.99

salivary:5.47

CAGE

uterus:0.06

placenta:0

prostate:0

ovary:0.07

testis:0.43

heart:0.12

muscle:0.25

esophagus:0

stomach:-

intestine:1.13

colon:0.84

liver/hepato:0

lung:0

bladder:0

kidney:0

pituitary:2.78

thyroid/parathyroid:0

adrenal gland:-

pancreas:2.48

breast:0

salivary:0

RNA-seq

uterus:-

placenta:-

prostate:0.42

ovary:0.76

testis:0.13

heart:0.28

muscle:0.11

esophagus:-

stomach:-

intestine:-

colon:0.36

liver/hepato:0.17

lung:0.22

bladder:-

kidney:0.53

pituitary:-

thyroid/parathyroid:0.24

adrenal gland:0.55

pancreas:-

breast:0.30

salivary:-

IDs

Refseq ID	NM_001127612
Gene ID	5080
Unigene ID	Hs.611376
Probe set ID	205646_s_at [HG-U133_Plus_2]
Ensembl ID	ENSG00000007372
GTEx ID	ENSG00000007372

Orthologous Gene

Mouse[6]	NM_013627
Rat [0]

Chromosomal Region

11p13 [31,806,340 - 31,839,509]

Search genes near this gene
- Between -5kb and +5kb
- Between -10kb and +10kb

Gene Family (Interpro ID)

IPR001356	Homeobox
IPR009057	Homeodomain-like
IPR012287	Homeodomain-related
IPR001523	Paired box protein, N-terminal
IPR011991	Winged helix repressor DNA-binding

Gene Ontology (GO ID)

Biological Process

GO:0048708	astrocyte differentiation
GO:0007411	axon guidance
GO:0001568	blood vessel development
GO:0001709	cell fate determination
GO:0007417	central nervous system development
GO:0021796	cerebral cortex regionalization
GO:0021902	commitment of a neuronal cell to a specific type of neuron in the forebrain
GO:0009950	dorsal/ventral axis specification
GO:0048596	embryonic camera-type eye morphogenesis
GO:0001654	eye development
GO:0042462	eye photoreceptor cell development
GO:0021797	forebrain anterior/posterior pattern formation
GO:0021798	forebrain dorsal/ventral pattern formation
GO:0021905	forebrain-midbrain boundary formation
GO:0042593	glucose homeostasis
GO:0030902	hindbrain development
GO:0030216	keratinocyte differentiation
GO:0032808	lacrimal gland development
GO:0002088	lens development in camera-type eye
GO:0050680	negative regulation of epithelial cell proliferation
GO:0050768	negative regulation of neurogenesis
GO:0045665	negative regulation of neuron differentiation
GO:0048663	neuron fate commitment
GO:0001764	neuron migration
GO:0021778	oligodendrocyte cell fate specification
GO:0009887	organ morphogenesis
GO:0003322	pancreatic A cell development
GO:0021983	pituitary gland development
GO:0042660	positive regulation of cell fate specification
GO:0030858	positive regulation of epithelial cell differentiation
GO:0010628	positive regulation of gene expression
GO:0002052	positive regulation of neuroblast proliferation
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0045893	positive regulation of transcription, DNA-dependent
GO:0033365	protein localization in organelle
GO:0016567	protein ubiquitination
GO:0030334	regulation of cell migration
GO:0048505	regulation of timing of cell differentiation
GO:0021918	regulation of transcription from RNA polymerase II promoter involved in somatic motor neuron fate commitment
GO:0021912	regulation of transcription from RNA polymerase II promoter involved in spinal cord motor neuron fate specification
GO:0021913	regulation of transcription from RNA polymerase II promoter involved in ventral spinal cord interneuron specification
GO:0009611	response to wounding
GO:0007435	salivary gland morphogenesis
GO:0007224	smoothened signaling pathway
GO:0006366	transcription from RNA polymerase II promoter
GO:0007601	visual perception

Cellular Component

GO:0005737	cytoplasm
GO:0000790	nuclear chromatin
GO:0005730	nucleolus
GO:0005634	nucleus

Molecular Function

GO:0003680	AT DNA binding
GO:0070410	co-SMAD binding
GO:0003677	DNA binding
GO:0003690	double-stranded DNA binding
GO:0035035	histone acetyltransferase binding
GO:0005515	protein binding
GO:0019901	protein kinase binding
GO:0070412	R-SMAD binding
GO:0003700	transcription factor activity
GO:0008134	transcription factor binding
GO:0031625	ubiquitin protein ligase binding
GO:0004842	ubiquitin-protein ligase activity

paired box 6

Synonym

Expression Pattern

Choropleth map on BodyParts3D

Classification in 40 Organs

Gene Information

IDs

Orthologous Gene

Chromosomal Region

Gene Family (Interpro ID)

Link to Pubmed (Pubmed ID)

Gene Ontology (GO ID)

Biological Process

Cellular Component

Molecular Function