sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 3

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Synonym

Testican-3 precursor, SPOCK3, UNQ409/PRO771, TICN3, TES-3, HSAJ1454, testican-3

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:487.10 cerebellum:50.40 brain stem:- corpus callosum/glia:2566.20 pineal gland:- peripheral nerve:30.70 spine:- retina:- eye:23.50 artery/aorta:- vein:- lymphnode:- peripheral blood:36.40 spleen:- thymus:- bone marrow:- adipose:- bone:- skin:19.20
GeneChip cerebrum:5.07 cerebellum:3.88 brain stem:5.74 corpus callosum/glia:6.12 pineal gland:- peripheral nerve:4.51 spine:5.53 retina:- eye:- artery/aorta:2.75 vein:2.91 lymphnode:2.69 peripheral blood:- spleen:2.67 thymus:2.71 bone marrow:2.84 adipose:2.78 bone:- skin:2.86
CAGE cerebrum:4.88 cerebellum:- brain stem:5.56 corpus callosum/glia:5.46 pineal gland:1.14 peripheral nerve:- spine:5.35 retina:- eye:- artery/aorta:1.38 vein:1.29 lymphnode:0.54 peripheral blood:- spleen:0 thymus:0.18 bone marrow:- adipose:0 bone:- skin:-
RNA-seq cerebrum:0.00 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:0.00 peripheral blood:- spleen:- thymus:- bone marrow:- adipose:0 bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:9.10 placenta:- prostate:56.30 ovary:- testis:4.30 heart:12.80 muscle:- esophagus:- stomach:- intestine:32.40 colon:-     liver/hepato:-        lung:14.70    bladder:- kidney:- pituitary:- thyroid/parathyroid:- adrenal gland:- pancreas:71.10 breast:- salivary:-
GeneChip uterus:2.75 placenta:2.70 prostate:4.39 ovary:2.74 testis:2.68 heart:2.69 muscle:2.91 esophagus:2.67 stomach:2.69 intestine:2.80 colon:2.80 liver/hepato:2.79 lung:2.76 bladder:- kidney:2.75 pituitary:2.73 thyroid/parathyroid:2.67 adrenal gland:2.66 pancreas:2.78 breast:2.60 salivary:2.75
CAGE uterus:1.10 placenta:0.08 prostate:4.40 ovary:1.56 testis:1.37 heart:1.08 muscle:0 esophagus:1.08 stomach:- intestine:1.10 colon:0.95     liver/hepato:0.14    lung:0.51 bladder:1.06 kidney:0.67 pituitary:0.62 thyroid/parathyroid:0.67 adrenal gland:- pancreas:0 breast:0 salivary:0.36
RNA-seq uterus:- placenta:- prostate:0 ovary:0.00 testis:0.00 heart:0.00 muscle:0.00 esophagus:- stomach:- intestine:- colon:0.00     liver/hepato:0        lung:0.00    bladder:- kidney:0.00 pituitary:- thyroid/parathyroid:0.00 adrenal gland:0.00 pancreas:- breast:0.00 salivary:-

Gene Information

IDs

Refseq ID NM_016950
Gene ID 50859
Unigene ID Hs.481133
Probe set ID 206434_at  [HG-U133_Plus_2]
Ensembl ID ENSG00000196104
GTEx ID ENSG00000196104

Orthologous Gene

Mouse[1]  NM_023689
Rat[1]  NM_001107310

Chromosomal Region

4q32.3  [167,654,535  -  168,155,947]

Gene Family (Interpro ID)

IPR002350  Proteinase inhibitor I1, Kazal

Link to Pubmed  (Pubmed ID)

11751414
12477932
12810672
12975309
14702039
15489334
17207965
19144404
20379614
22610502
23251661

Gene Ontology  (GO ID)

Biological Process

GO:0010951  negative regulation of endopeptidase activity
GO:0019800  peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan
GO:0007165  signal transduction

Cellular Component

GO:0031012  extracellular matrix
GO:0005615  extracellular space
GO:0005578  proteinaceous extracellular matrix

Molecular Function

GO:0005509  calcium ion binding
GO:0005539  glycosaminoglycan binding
GO:0008191  metalloendopeptidase inhibitor activity