inositol polyphosphate-5-phosphatase K

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Synonym

-

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:83 cerebellum:50.40 brain stem:- corpus callosum/glia:58.30 pineal gland:- peripheral nerve:- spine:- retina:118.60 eye:205.70 artery/aorta:89.90 vein:- lymphnode:161.80 peripheral blood:127.50 spleen:113.40 thymus:25.80 bone marrow:39.40 adipose:- bone:25.60 skin:33.60
GeneChip cerebrum:6.10 cerebellum:6.10 brain stem:6.27 corpus callosum/glia:5.95 pineal gland:- peripheral nerve:6.13 spine:5.85 retina:- eye:- artery/aorta:6.47 vein:6.33 lymphnode:6.20 peripheral blood:- spleen:6.09 thymus:6.40 bone marrow:6.34 adipose:6.58 bone:- skin:6.49
CAGE cerebrum:3.42 cerebellum:- brain stem:3.39 corpus callosum/glia:3.58 pineal gland:2.59 peripheral nerve:- spine:3.40 retina:- eye:- artery/aorta:3.52 vein:3.58 lymphnode:3.53 peripheral blood:- spleen:3.46 thymus:3.75 bone marrow:- adipose:3.99 bone:- skin:-
RNA-seq cerebrum:2.92 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:3.67 peripheral blood:- spleen:- thymus:- bone marrow:- adipose:4.23 bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:72.90 placenta:80.10 prostate:90.10 ovary:74.50 testis:82.20 heart:51.10 muscle:80.40 esophagus:- stomach:21.20 intestine:32.40 colon:67.80     liver/hepato:-        lung:39.10    bladder:- kidney:20.80 pituitary:116 thyroid/parathyroid:- adrenal gland:- pancreas:53.30 breast:37.20 salivary:-
GeneChip uterus:6.03 placenta:5.94 prostate:6.28 ovary:6.01 testis:7 heart:6.36 muscle:6.38 esophagus:6.26 stomach:6.13 intestine:6.41 colon:6.48 liver/hepato:6.09 lung:6.74 bladder:- kidney:6.26 pituitary:6.16 thyroid/parathyroid:6.25 adrenal gland:6.30 pancreas:6.30 breast:6.19 salivary:6.56
CAGE uterus:3.24 placenta:3.39 prostate:3.30 ovary:2.99 testis:3.85 heart:3.54 muscle:3.60 esophagus:3.30 stomach:- intestine:3.44 colon:3.42     liver/hepato:3.03    lung:4.00 bladder:2.95 kidney:3.25 pituitary:3.03 thyroid/parathyroid:4.06 adrenal gland:- pancreas:3.16 breast:4.53 salivary:3.49
RNA-seq uterus:- placenta:- prostate:3.55 ovary:2.85 testis:3.87 heart:2.91 muscle:3.81 esophagus:- stomach:- intestine:- colon:3.22     liver/hepato:2.39        lung:3.24    bladder:- kidney:3.19 pituitary:- thyroid/parathyroid:4.87 adrenal gland:3.56 pancreas:- breast:4.43 salivary:-

Gene Information

IDs

Refseq ID NM_016532
Gene ID 51763
Unigene ID Hs.632238
Probe set ID 202781_s_at  [HG-U133_Plus_2]
Ensembl ID ENSG00000132376
GTEx ID ENSG00000132376

Orthologous Gene

Mouse[2]  NM_008916
Rat[2]  NM_008916

Chromosomal Region

17p13.3  [1,397,872  -  1,420,182]

Gene Family (Interpro ID)

IPR005135  Endonuclease/exonuclease/phosphatase
IPR000300  Inositol polyphosphate related phosphatase

Link to Pubmed  (Pubmed ID)

8968499
8968500
10753883
11509665
12477932
12536145
12556481
12621583
16002321
16189514
17353931
18573875
18774950
21639856
21890473
21900206
21903422
21988832
22751929
22815484
24250222
24816145

Gene Ontology  (GO ID)

Biological Process

GO:0030036  actin cytoskeleton organization
GO:0071320  cellular response to cAMP
GO:0071364  cellular response to epidermal growth factor stimulus
GO:0032870  cellular response to hormone stimulus
GO:0032869  cellular response to insulin stimulus
GO:0071356  cellular response to tumor necrosis factor
GO:0016311  dephosphorylation
GO:0007186  G-protein coupled receptor protein signaling pathway
GO:0042593  glucose homeostasis
GO:0001701  in utero embryonic development
GO:0046855  inositol phosphate dephosphorylation
GO:0043922  negative regulation by host of viral transcription
GO:0051926  negative regulation of calcium ion transport
GO:0035305  negative regulation of dephosphorylation
GO:0010829  negative regulation of glucose transport
GO:0045719  negative regulation of glycogen biosynthetic process
GO:0046627  negative regulation of insulin receptor signaling pathway
GO:0043407  negative regulation of MAP kinase activity
GO:0033137  negative regulation of peptidyl-serine phosphorylation
GO:0010801  negative regulation of peptidyl-threonine phosphorylation
GO:0001933  negative regulation of protein amino acid phosphorylation
GO:0006469  negative regulation of protein kinase activity
GO:0051898  negative regulation of protein kinase B signaling cascade
GO:0045869  negative regulation of retroviral genome replication
GO:0051497  negative regulation of stress fiber formation
GO:0045892  negative regulation of transcription, DNA-dependent
GO:0006661  phosphatidylinositol biosynthetic process
GO:0046856  phosphoinositide dephosphorylation
GO:0006644  phospholipid metabolic process
GO:0045893  positive regulation of transcription, DNA-dependent
GO:0005979  regulation of glycogen biosynthetic process

Cellular Component

GO:0005737  cytoplasm
GO:0005829  cytosol
GO:0005783  endoplasmic reticulum
GO:0016020  membrane
GO:0043005  neuron projection
GO:0005634  nucleus
GO:0048471  perinuclear region of cytoplasm
GO:0005886  plasma membrane
GO:0001726  ruffle
GO:0032587  ruffle membrane
GO:0005802  trans-Golgi network

Molecular Function

GO:0016312  inositol bisphosphate phosphatase activity
GO:0046030  inositol trisphosphate phosphatase activity
GO:0004445  inositol-polyphosphate 5-phosphatase activity
GO:0042577  lipid phosphatase activity
GO:0034594  phosphatidylinositol trisphosphate phosphatase activity
GO:0034485  phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity
GO:0034595  phosphoinositide 5-phosphatase activity
GO:0005515  protein binding
GO:0005000  vasopressin receptor activity