6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2

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Synonym

PFK-2/FBPase-2, DKFZp781D2217, PFKFB2, 6PF-2-K/Fru-2,6-P2ASE heart-type isozyme, MGC138308, MGC138310

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:36.70 cerebellum:25.20 brain stem:- corpus callosum/glia:58.30 pineal gland:148.30 peripheral nerve:- spine:- retina:- eye:35.30 artery/aorta:- vein:- lymphnode:20.20 peripheral blood:- spleen:37.80 thymus:64.40 bone marrow:19.70 adipose:- bone:25.60 skin:76.80
GeneChip cerebrum:5.07 cerebellum:4.09 brain stem:4.58 corpus callosum/glia:5.49 pineal gland:- peripheral nerve:4.84 spine:5.44 retina:- eye:- artery/aorta:3.89 vein:4.19 lymphnode:3.85 peripheral blood:- spleen:4.05 thymus:5.18 bone marrow:5.38 adipose:4.07 bone:- skin:3.97
CAGE cerebrum:3.53 cerebellum:- brain stem:3.54 corpus callosum/glia:4.13 pineal gland:3.55 peripheral nerve:- spine:4.16 retina:- eye:- artery/aorta:2.15 vein:2.54 lymphnode:2.67 peripheral blood:- spleen:2.66 thymus:2.78 bone marrow:- adipose:1.84 bone:- skin:-
RNA-seq cerebrum:1.93 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:1.36 peripheral blood:- spleen:- thymus:- bone marrow:- adipose:0.78 bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:36.50 placenta:21.90 prostate:22.50 ovary:- testis:56.20 heart:25.50 muscle:20.10 esophagus:- stomach:21.20 intestine:- colon:59.40     liver/hepato:31.70        lung:24.40    bladder:- kidney:52 pituitary:- thyroid/parathyroid:- adrenal gland:- pancreas:71.10 breast:18.60 salivary:-
GeneChip uterus:3.96 placenta:3.80 prostate:3.96 ovary:3.97 testis:3.95 heart:5.61 muscle:6.17 esophagus:4.68 stomach:4.29 intestine:4.92 colon:4.72 liver/hepato:3.87 lung:4.01 bladder:- kidney:5.51 pituitary:6.11 thyroid/parathyroid:5.91 adrenal gland:4.08 pancreas:5.19 breast:3.83 salivary:4.18
CAGE uterus:2.33 placenta:1.66 prostate:1.95 ovary:2.20 testis:3.00 heart:3.28 muscle:4.02 esophagus:2.51 stomach:- intestine:3.87 colon:3.48     liver/hepato:1.90    lung:3.22 bladder:1.89 kidney:4.03 pituitary:4.36 thyroid/parathyroid:3.82 adrenal gland:- pancreas:2.48 breast:1.68 salivary:2.80
RNA-seq uterus:- placenta:- prostate:0.75 ovary:1.48 testis:1.44 heart:3.36 muscle:3.98 esophagus:- stomach:- intestine:- colon:0.90     liver/hepato:0.72        lung:1.04    bladder:- kidney:3.95 pituitary:- thyroid/parathyroid:3.04 adrenal gland:0.91 pancreas:- breast:0.53 salivary:-

Gene Information

IDs

Refseq ID NM_001018053
Gene ID 5208
Unigene ID Hs.282702
Probe set ID 209992_at  [HG-U133_Plus_2]
Ensembl ID ENSG00000123836
GTEx ID ENSG00000123836

Orthologous Gene

Mouse[7]  NM_001162415, NM_001162416, NM_008825
Rat[3]  NM_001033964, NM_001033965, NM_080477

Chromosomal Region

1q32.2  [207,222,801  -  207,254,369]

Gene Family (Interpro ID)

IPR016260  Bifunctional 6-phosphofructo-2-kinase/fructose-2, 6-bisphosphate 2-phosphatase
IPR003094  Fructose-2,6-bisphosphatase

Link to Pubmed  (Pubmed ID)

1322130
1655632
7574501
7904197
8387495
9464277
9652401
11069105
11129574
11245921
11374908
11522786
12065600
12477932
12853467
14702039
15324660
15489334
15925437
16025159
16196087
16710414
17979178
18039179
19423540
20406964
20438785
20958264
21092265
21139048
21963094
22241065
22939629
23000965
23457334
24255178
24634222
24816145

Gene Ontology  (GO ID)

Biological Process

GO:0005975  carbohydrate metabolic process
GO:0006003  fructose 2,6-bisphosphate metabolic process
GO:0006000  fructose metabolic process
GO:0006006  glucose metabolic process
GO:0006096  glycolysis
GO:0006089  lactate metabolic process
GO:0033133  positive regulation of glucokinase activity
GO:0032024  positive regulation of insulin secretion
GO:0006090  pyruvate metabolic process
GO:0009749  response to glucose stimulus

Cellular Component

GO:0005829  cytosol

Molecular Function

GO:0003873  6-phosphofructo-2-kinase activity
GO:0005524  ATP binding
GO:0004331  fructose-2,6-bisphosphate 2-phosphatase activity
GO:0005515  protein binding
GO:0019901  protein kinase binding